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 Oral hygiene compositions and polymers active therein

Details
Inventors: Humphries, Martyn; Nemcek, Jozef; Jaworzyn, Joseph F.; Cantwell, John B.; Gerrard, John J.;
Assignee: Imperial Chemical Industries PLC (London, GB2)
Primary Examiner: Lipman; Bernard
Assistant Examiner:
Attorney, Agent or Firm: Cushman, Darby & Cushman

Oral hygiene compositions effective for preventing the adherent deposition of cariogenic bacteria on teeth comprise as active constituents polymers having defined repeating units comprising hydrocarbyl groups with pendant carboxyl and pendant polyalkylene oxide groups in defined ratio. The polymers themselves, their prepartion, and a process for treating teeth with the compositions are also claimed.

DETAILED DESCRIPTION We claim: 1.
An un-filled oral hygiene composition consisting essentially of an aqueous solution of an effective amount of at least one polymer and a pharmaceutically acceptable vehicle, which polymer comprises one or more repeating units of general structure A ##STR32## and one or more repeating units of general structure B ##STR33## wherein X, which in the repeating units of structure A may be the same or different, and Y, which in the repeating units of structure B may be the same or different, are unsubstituted hydrocarbyl residues or residues substituted with groups such as hydroxy, alkoxy and halogen provided that the desired properties of the polymer are not adversely affected by such substituents, said residues providing a backbone for the polymer; R.
sup.
1, which in the same repeating unit of structure B (when n or q is 2 or more) or in different repeating units of structure B may be the same or different, is hydrogen or methyl; R.
sup.
2, which in the same repeating unit of structure B (when n or q is 2 or more) or in different repeating units of structure B may be the same or different, is hydrogen or methyl; except that R.
sup.
1 and R.
sup.
2 in a single unit (CHR.
sup.
1 CHR.
sup.
2 O) cannot both be methyl; R.
sup.
3, which in the same repeating unit of structure B (when q is 2 or more) or in different repeating units of structure B may be the same or different, is hydrogen, or a lower alkyl group containing up to 5 carbon atoms, or an acyl group derived from an alkanoic acid having up to 5 carbon atoms; n is a number of from 1 to 60; p is a number of from 1 to 4, and q is a number of from 1 to 4; and wherein each (CO.
sub.
2 H) group is joined via an intermediary or intermediaries L to the hydrocarbyl residue X, and in cases where p is 2 to 4 may be joined by L to the same or different carbon atoms of X; and wherein L represents one or more intermediaries, and wherein L may be the same or different in the repeat units of structure A and is selected from one or more direct links and one or more groups of atoms each group providing a chain of one or more atoms for linking a (CO



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