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Stable stannous chloride composition for labeling with radioactive technetium
| Details |
Inventors: Azuma, Makoto; Takahashi, Jun; Yamauchi, Hirohiko; Ueda, Nobuo;
Assignee: Nihon Medi-Physics Co. Ltd. (Hyogo, JP)
Primary Examiner: Lovering; Richard D.
Assistant Examiner: Harris; Cynthia
Attorney, Agent or Firm:
A non-radioactive labeling composition for preparation of a technetium 99m-labeled radioactive diagnostic agent, which comprises a small amount of a lyophilized product obtained from a stannous chloride solution having a high concentration of stannous chloride charged in a container. |
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DETAILED DESCRIPTION What is claimed is: 1.
A process for labelling red blood cells with 99m-technetium, which comprises the steps of (a) dissolving a dry, solid, reductive composition in water to form a resultant solution; said dry, solid, reductive composition being prepared by forming an aqueous solution containing stannous chloride in a concentration of not less than 0.
5 mol/liter by dissolving stannous chloride alone in an aqueous solvent, charging an amount of not more than 500 microliters of said aqueous solution into a container and lyophilizing the charged aqueous solution in said container, (b) intravenously administering said resultant solution into a mammalian body, and (c) subsequently intravenously administering 99m-technetium in a pertechnetate form into said body.
2.
The process according to claim 1, wherein the mammalian body is a human body.
3.
The process according to claim 2, wherein step (c) is carried out within a pertechnetate reduction effective period of time.
Description:
The present invention relates to a stable stannous chloride composition for labeling with radioactive technetium.
More particularly, it relates to a stable and less toxic, non-radioactive labeling composition useful for preparation of a radioactive technetium-labeled tin colloid for liver scintigraphy or for preparation of radioactive technetium-labeled red blood cells in a human body.
Since technetium-99m (.
sup.
99m Tc) emits only gamma-rays of about 140 KeV without beta-rays and has a short half life (i.
e.
about 6 hours), it is quite suitable as a nuclide to be introduced into human bodies for diagnosis.
Because of this reason, its utilization in the field of nuclear medicine has rapidly developed and expanded in recent years.
Among various .
sup.
99m Tc-labeled radioactive medicines as recently developed, there are included those which are used for scintigraphic visualization of the form or shape of a liver by utilization of the phenomenon that a certain kind of colloid particles is taken into the Kupffer cells of the liver
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Audio Signal Processing 
