DETAILED DESCRIPTION OF THE INVENTION The invention also includes the cationic salts of .
beta.
-oxo-2-thiophenepropionitrile with pharmacologically acceptable metal cations, ammonium, amine cations, or quaternary ammonium cations.
Preferred metal cations are those derived from the alkali metals, e.
g.
lithium, sodium and potassium, and from the alkaline earth metals, e.
g.
magnesium and calcium, although cationic forms of other metals, e.
g.
aluminum, zinc, iron and in particular copper, are within the scope of the invention.
Pharmacologically acceptable amine cations and those derived from primary, secondary or tertiary amines such as mono-, di- or trimethylamine, ethylamine, dibutylamine, triisopropylamine, N-methylhexylamine, decylamine, dodecylamine, allylamine, crotylamine, cyclopentylamine, dicyclohexylamine, mono- or dibenzylamine, .
alpha.
- or .
beta.
-phenylethylamine, ethylenediamine, diethylenetriamine, and aryliphatic amines containing up to and including 18 carbon atoms, as well as heterocyclic amines, e.
g.
piperidine, morpholine, pyrrolidine, piperazine and lower alkyl derivative thereof, e.
g.
1-methylpiperidine, 4-ethylmorpholine, 1-isopropylpyrrolidine, 2-methylpyrrolidine, 1,4-dimethylpiperazine, 2-methylpiperidine, and the like, as well as amines containing water-solubilizing or hydrophilic groups, e.
g.
mono-, di-, or triethanolamine, ethyldiethanolamine, N-butylethanolamine, 2-amino-1-butanol, 2-amino-2-ethyl-1,3-propanediol, 2-amino-2-methyl-1-propanol, tris(hydroxy-methyl)aminomethane, N-phenylethanolamine, N-(p-tert-amylphenyl)diethanolamine, galactamine, N-methylglucamine, N-methylglucosamine, ephedrine, phenylephrine, epinephrine, procaine, and the like.
Examples of suitable pharmacologically acceptable quaternary ammonium cations are tetramethylammonium, tetraethylammonium, benzyltrimethylammonium, phenyltriethylammonium and the like.
.
beta.
-Oxo-2-thiophenepropionitrile and the cationic salts thereof have been found to be highly useful for meliorating inflammation and inhibiting joint deterioration in mammals when administered in amounts ranging from about one milligram to about 250 mg
|
Communications 
