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Antigenic-proteins-of-Borrelia-burgdorferi

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Antigenic proteins of Borrelia burgdorferi

Details

Inventors: Simpson, Warren; Schwan, T. G.;
Assignee:
Primary Examiner: Bidwell; Carol E.
Assistant Examiner:
Attorney, Agent or Firm: Morgan & Finnegan

The present invention relates to antigenic proteins specific to Borrelia burgdorferi which have a molecular weight of 28 kDa or 39 kDa as determined by SDS-PAGE and are reactivity with Lyme borreliosis serum or fragments thereof and to the corresponding DNA. The proteins, especially the 39 kDa proteins (.alpha. and .beta.) can be used to diagnosis mammals previously or currently infected with the Lyme borreliosis causing agent.

DETAILED DESCRIPTION It is an object of the present invention to provide a means for detecting mammals previously or presently infected with Lyme disease.
In one embodiment, the present invention relates to substantially pure forms of a Borrelia burgdorferi proteins which have molecular weights of about 39 kilodaltons and a protein which has a molecular weight of about 28 kilodaltons as determined by SDS-PAGE and which are reactive with Lyme borreliosis serum.
In another embodiment, the present invention relates to Borrelia burgdorferi proteins substantially free of proteins with which they are normally associated that have molecular weights of about 39 kilodaltons and a protein which has a molecular weight of about 28 kilodaltons as determined by SDS-PAGE and which are reactive with Lyme borreliosis serum.
In yet another embodiment, the present invention relates to a DNA fragment encoding all, or a unique portion, of the above described 39 kilodalton Borrelia burgdorferi proteins or the 28 kilodalton Borrelia burgdorferi protein.
In another embodiment, the present invention relates to a DNA fragment encoding all, or a unique portion, of one of the above described 39 kilodalton Borrelia burgdorferi proteins.
In a further embodiment, the present invention relates to a recombinant DNA molecule comprising a fragment of the above described DNA and a vector.
The invention also relates to a host cell stably transformed with such a recombinant DNA molecule in a manner allowing expression of the Borrelia burgdorferi proteins encoded in the DNA fragment.
In another embodiment, the present invention relates to a method of producing recombinant Borrelia burgdorferi proteins of about 39 kilodaltons and a protein of about 28 kilodaltons and which are reactive with Lyme borreliosis serum which method comprises culturing host cells expressing the proteins, in a manner allowing expression of the proteins, and isolating the proteins from the host cells.
In a further embodiment, the present invention relates to a purified form of an antibody specific for the above described 39 kilodalton Borrelia burgdorferi proteins or a unique fragment thereof or the above described 28 kilodalton Borrelia burgdorferi protein or a unique fragment thereof

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