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Antithrombin-nucleotides-and-proteins-from-horn-fly

Methods and reagents for HLA class I A locus DNA typing

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Antithrombin nucleotides and proteins from horn fly

Details

Inventors: Cupp, Eddie Wayne; Cupp, Mary Smith;
Assignee: Auburn University (Auburn, AL)
Primary Examiner: Weber; Jon
Assistant Examiner: Robinson; Hope A.
Attorney, Agent or Firm: Alston & Bird LLP

Compositions and methods for preventing hematophagous infestation of cattle are provided, directed at isolated proteins with antithrombin activity and nucleotide sequences encoding the proteins. The protein named thrombostasin is isolated from the salivary glands of Haematobia irritans. The compositions are useful as veterinary vaccines in prevention of blood-feeding in cattle by the infesting horn fly. The proteins of the invention are also useful in treatment of thrombosis.

DETAILED DESCRIPTION Isolated proteins with antithrombin activity and nucleotide sequences encoding the proteins are provided.
The protein named thrombostasin is isolated from the salivary glands of Haematobia irritans, the blood-feeding horn fly.
The provided proteins and nucleotides are particularly useful as veterinary vaccines in prevention of blood-feeding in cattle by the infesting horn fly.
The proteins of the invention are also useful in treatment of thrombosis.
Methods of administering the proteins and nucleotide sequences of the invention are also provided.

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