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Biodegradable-and-biocompatible-polymeric-microspheres-encapsulating-Salmonella-enteritidis-bacteria

Capsid forming and cystein modified chimaeric MS2-coat protein

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Polynucleotides related to monoclonal antibody 1A7 and use for the treatment of melanoma and small cell carcinoma

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The present invention relates to a strategically modified hepatitis B core (HBc) protein that is ...

Chimeric biotin-binding papillomavirus protein

OF THE INVENTION The first domain of the chimeric protein includes at least a portion of a ...

Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell

OF THE INVENTION DEFINITIONS As used in this application, the following words or phrases have the ...

MYPPPY variants of CTL A4 and uses thereof

OF THE INVENTION Definition As used in this application, the following words or phrases have the ...

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OF THE INVENTION DEFINITION As used in this application, the following words or phrases have the ...

CTLA4/CD28Ig hybrid fusion proteins and uses thereof

OF THE INVENTION DEFINITION As used in this application, the following words or phrases have the ...

Method of regulating cellular processes mediated by B7 and CD28

Accordingly, the present invention identifies the B7 antigen as a ligand recognized by the CD28 ...

Methods of inhibiting T cell proliferation or IL-2 accumulation with CTLA4- specific antibodies

This invention is based, at least in part, on the discovery of novel ligands which bind a T cell ...

Biodegradable and biocompatible polymeric microspheres encapsulating Salmonella enteritidis bacteria

Details

Inventors: Yang, Yi-Yan; Kwang, Jimmy; Chen, Xueqin; Chung, Tai-Shung; Liu, Wei;
Assignee: Agency for Science, Technology and Research (Centros, SG)
Primary Examiner: Minnifield; Nita
Assistant Examiner: Ford; Vanessa L.
Attorney, Agent or Firm: Rothwell, Figg, Ernst & Manbeck

Biodegradable and biocompatible polymeric microspheres encapsulating Salmonella enteritidis are administered to chickens to provide the chickens with sustained protection against S. enteritidis infections.

DETAILED DESCRIPTION In accordance with the present invention, there are provided long term release, biocompatible and biodegradable, porous, polymeric microcapsules comprising whole killed S.
enteritidis bacteria.
Upon administration, the S.
enteritidis is released in a biphasic pattern, wherein about 20% to about 50% of the S.
enteritidis is released in an initial burst over the period of about 7 to 15 days, followed by the release of the remaining S.
enteritidis in a steady and sustained manner over a period of about 70 to about 100 days.
The microcapsules can be made by a (water-in-oil)-in-water emulsion process.

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