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Compositions-and-methods-for-the-detection-quantitation-and-purification-of-antigen-specific-T-cells

System to detect protein-protein interactions

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Use of purified invaplex from gram negative bacteria as a vaccine

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Method for producing a nematocidal composition by heat treating a pH-adjusted fermentation broth

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Compositions and methods for the detection, quantitation and purification of antigen-specific T cells

Details

Inventors: Altman, John D.; McHeyzer-Williams, Michael G.; Davis, Mark M.;
Assignee: The Board of Trustees of the Leland Stanford Junior University (Stanford, CA)
Primary Examiner: Saunders; David
Assistant Examiner:
Attorney, Agent or Firm: Sherwood; Pamela J. Fish & Richardson P.C.

T cells are specifically labeled according to their antigen receptor by binding of a multimeric binding complex. The complex is prepared with major histocompatibility complex protein subunits having a homogeneous population of peptides bound in the antigen presentation site. The multimeric MHC-antigen complex forms a stable structure with T cells, thereby allowing for the labeling, identification and separation of specific T cells.

DETAILED DESCRIPTION Methods and compositions are provided for labeling T cells according to the specificity of their antigen receptor.
A stable multimeric complex is prepared with major histocompatibility complex protein subunits having a substantially homogeneous bound peptide population.
The multimeric MHC-antigen complex forms a stable structure with T cells recognizing the complex through their antigen receptor, thereby allowing for the labeling, identification and separation of specific T cells.
The subject methods are also useful for the diagnosis and monitoring of diseases having an immune component.

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