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| Vaccine against Gram-negative bacterial infections |
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DNA encoding IL-1 receptor accessory protein
| Details |
Inventors: Sims, John E.; Smith, Dirk E.;
Assignee: Immunex Corporation (Thousand Oaks, CA)
Primary Examiner: Li; Ruixiang
Assistant Examiner:
Attorney, Agent or Firm: Henry; Janis C.
DNA encoding IL-1R AcP splice variant polypeptides, the polypeptides and methods for using the encoded polypeptides are disclosed. |
|
DETAILED DESCRIPTION What is claimed is: 1.
An isolated polynucleotide comprising SEQ ID NO:1 wherein the nucleic acid at 1792 is A or C.
2.
An isolated polynucleotide comprising a nucleic acid that encodes a polypeptide comprising SEQ ID NO:2, wherein the amino acid 598 is Thr or Pro.
3.
An isolated polynucleotide comprising a molecule selected from the group consisting of: a) A polynucleotide that encodes a polypeptide comprising amino acid residues 384 687 of SEQ ID NO:2, wherein the amino acid at 598 is Thr or Pro; b) A polynucleotide that encodes a polypeptide comprising amino acid residues 379 687 of SEQ ID NO:2, wherein the amino acid at 598 is Thr or Pro; c) A polynucleotide that encodes a polypeptide comprising amino acid residues 449 687 of SEQ ID NO:2, wherein the amino acid at 598 is Pro or Thr; d) A polynucleotide that encodes a fragment of a polypeptide consisting of amino acid residues selected from the group consisting of residues 384 687 of SEQ ID NO:2, residues 379 687 of SEQ ID NO:2, and residues 449 687 of SEQ ID NO:2 wherein the amino acid at 598 is Thr or Pro, and wherein the fragment interacts with an IL-1R signal transduction factor; e) a full complement of a polynucleotide that hybridizes to nucleotides 1348 2061 of SEQ ID NO: 1 under conditions of moderate stringency in 50% formamide and 6.
times.
SSC, at 42.
degree.
C.
with washing conditions of 60.
degree.
C.
, 0.
5.
times.
SSC, 0.
1% SDS; wherein the complement of the polynucleotide encodes a polypeptide that interacts with an IL-1R signal transduction factor; and f) a polynucleotide that encodes a polypeptide that is at least 95% identical to an amino acid sequence consisting of amino acid residues selected from the group consisting of residues 384 687 of SEQ ID NO: 2, residues 379 687 of SEQ ID NO:2, and residues 449 687 of SEQ ID NO: 2, wherein the amino acid at 598 is Thr or Pro, and wherein the polypeptide interacts with an IL-1R signal transduction factor.
4.
An expression vector comprising a polynucleotide of claim 3
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Drugs 
