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Home Drugs Fusion-of-non-hemolytic-truncated-form-of-listeriolysin-O-to-antigens-to-enhance-immunogenicity

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 Fusion of non-hemolytic, truncated form of listeriolysin O to antigens to enhance immunogenicity

Details
Inventors: Paterson, Yvonne;
Assignee: The Trustees of the University of Pennsylvania (Philadelphia, PA)
Primary Examiner: Chan; Christina
Assistant Examiner: Huynh; Phuong
Attorney, Agent or Firm: Morgan, Lewis & Bockius, LLP

Methods for enhancing the immunogenicity of an antigen via fusion to a non-hemolytic truncated form of listeriolysin O are provided.

DETAILED DESCRIPTION An object of the present invention is to provide a method for enhancing the immunogenicity of an antigen which comprises fusing to the antigen a non-hemolytic truncated form of listeriolysin O (.
DELTA.
LLO).



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