HIV vaccine

DETAILED DESCRIPTION What is claimed is: 1.
A recombinant human immunodeficiency virus-1 (HIV-1), wherein the natural signal sequence (NSS) of the HIV-1 envelope glycoprotein gp120 of the virus is replaced with a signal sequence selected from the group consisting of mellitin signal sequence (MSS) and interleukin 3 signal sequence (ILSS).
2.
The HIV-1 of claim 1 wherein the retrovirus is avirulent.
3.
The HIV-1 of claim 2 wherein the retrovirus is rendered avirulent by deletion of the nef gene.
4.
The HIV-1 of claim 1 wherein the MSS is shown as SEQ ID NO 9.
5.
The HIV-1 of claim 1 wherein the ILSS is shown as SEQ ID NO 10.
6.
The HIV-1 of claim 4 wherein the retrovirus is avirulent.
7.
The HIV-1 of claim 5 wherein the retrovirus is avirulent.
8.
The HIV-1 of claim 6 wherein the retrovirus is rendered avirulent by deletion of the nef gene.
9.
The HIV-1 of claim 6 wherein the retrovirus is rendered avirulent by deletion of the nef gene.
10.
A immunogenic composition comprising an effective amount of the HIV-1 of claim 6.
11.
An immunogenic composition comprising an effective amount of the HIV-1 of claim 7.
12.
An immunogenic composition comprising an effective amount of the HIV-1 of claim 8.
13.
An immunogenic composition comprising an effective amount of the HIV-1 of claim 9.




Description: