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Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same
| Details |
Inventors: Swain, Philip A.; Schad, Victoria C.; Greenstein, Julia L.; Exley, Mark A.; Fox, Barbara S.; Powers, Stephen P.; Gefter, Malcolm L.;
Assignee: ImmuLogic Pharmaceutical Corporation (Waltham, MA)
Primary Examiner: Achutamurthy; Ponnathapura
Assistant Examiner: Ponnalun; P.
Attorney, Agent or Firm: Hale and Dorr LLP
Hapten-carrier conjugates capable of eliciting anti-hapten antibodies in vivo are disclosed. Methods of preparing the hapten-carrier conjugates and therapeutic compositions are also disclosed. Where the hapten is a drug of abuse, a therapeutic composition containing the hapten-carrier conjugate is particularly useful in the treatment of drug addiction, more particularly, cocaine addiction. Passive immunization using antibodies raised against conjugates of the instant invention is also disclosed. The therapeutic composition is suitable for co-therapy with other conventional drugs. |
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DETAILED DESCRIPTION The present invention overcomes the above mentioned drawbacks and provides methods for treating drug abuse.
Using therapeutic compositions, in particular hapten-carrier conjugates, the present invention elicits an immune response in the form of anti-drug antibodies within the addict which upon subsequent exposure to the drug in a vaccinated individual neutralizes the drug so the expected pharmacological effects are diminished, if not eliminated.
The present invention provides a therapeutic for drug addiction, particularly cocaine and nicotine addiction, based on vaccination of subjects with a drug/hapten-carrier conjugate, and more particularly, a cocaine-protein or nicotine-protein conjugate.
Therapeutic compositions of the invention comprise at least one hapten and at least one T cell epitope-containing carrier which when conjugated to form a hapten-carrier conjugate is capable of stimulating the production of anti-hapten antibodies.
The hapten can be a drug or drug derivative, particularly cocaine or nicotine.
When the therapeutic composition containing the drug/hapten-carrier conjugate is administered to an addicted individual, anti-drug antibodies specific to the drug are elicited.
A therapeutic immunization regimen elicits and maintains sufficiently high titers of anti-drug antibodies, such that upon each subsequent exposure to the drug during the period of protection provided by the therapeutic, anti-drug antibodies neutralize a sufficient amount of the drug in order to diminish, if not eliminate, the pharmacological effect of the drug.
Also provided are novel methods of preparing these conjugates.
A method of passive immunization is also provided, wherein a subject is treated with antibodies generated in a donor by vaccination with the hapten-carrier conjugate of the invention.
These and other features, aspects and advantages of the present invention will become more apparent and better understood with regard to the following drawings, description, and appended claims
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Drugs 
