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Ligand-for-vascular-endothelial-growth-factor-receptor

Secreted and transmembrane polypeptides and nucleic acids encoding the same

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Silver halide emulsions with recombinant collagen suitable for photographic application and also the preparation thereof

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DNA sequences coding for a protein conferring male sterility

Thus, in a first aspect the present invention provides recombinant or isolated Nucleic acid which: ...

Tumor associated nucleic acids and uses therefor

OF THE INVENTION The examples which follow show the isolation of nucleic acid molecules which code ...

Ligand for vascular endothelial growth factor receptor

Details

Inventors: Tchistiakova, Lioudmila; Li, Shengmin; Pietrzynski, Grzegorz; Alakhov, Valery;
Assignee: Supratek Pharma Inc. (CA)
Primary Examiner: Andres; Janet L.
Assistant Examiner: Wang; Chang-Yu
Attorney, Agent or Firm: Gibbons, Del Deo, Dolan, Griffinger & Vecchione

The present invention relates to compositions comprised of a peptide ligand or derivatives thereof that are capable of specific binding to the high affinity receptor-1 of vascular endothelial growth factor (VEGF) and structure similar receptors. The invention further provides a peptide ligand or derivatives thereof that are capable of inhibiting angiogenesis induced by VEGF. The present invention also provides a method for treatment or diagnosis of disease associated with angiogenesis in a patient in need of therapy comprising administering to the patient an effective amount of the pharmaceutical composition of the present invention and a pharmaceutical acceptable carrier.

DETAILED DESCRIPTION We claim: 1.
A compound comprising amino acid sequence Glu-Ile-Glu-Trp-Tyr-Ser-Trp-Val-Thr-His-Gly-Met-Tyr (SEQ ID NO:29).
2.
A pharmaceutical composition comprising the compound of claim 1 and a biological agent.
3.
A pharmaceutical composition comprising the compound of claim 1 and a carrier.
4.
The compound of claim 1, wherein the compound further comprises a biological agent conjugated thereto.
5.
The compound of claim 4, wherein said biological agent comprises a prodrug.
6.
The compound of claim 4, wherein said biological agent is a therapeutic agent.

Description:

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