Method and composition for an early vaccine to protect against both common infectious diseases and chronic immune mediated disorders or their sequelae

DETAILED DESCRIPTION The present invention may be used to overcome one or more deficiencies of the related art.
It relates to the discovery that a supplemental childhood immunization schedule of immunization with a pediatric or non-pediatric immunogen, starting prior to 42 days of age, can facilitate maturation and/or development of the immune system, and/or substantially decrease the incidence, frequency, prevalence or severity of, or prevent, at least one chronic immune mediated disorder, and/or a surrogate marker thereof, in addition to protection against at least one infectious diseases, depending on the immunogenic agent or immunogen used.
Without intending to be bound by any theory, early administration of immunogens can cause the release of lymphokines that may accelerate the maturation of the immune system.
The immunization may act in several ways including: A.
Enhancing destruction of autoimmune prone cells in the thymus; B.
Enhancing the flow of normal T-cells from the thymus; C.
Causing peripheral elimination of autoreactive T-cells that have escaped the thymus; D.
Causing the release of interferons which prevent infection with autoimmune causing viruses; and/or E.
Causing migration of macrophages into the area of administration as in an injection site and away from an vital organ like the islet cells of the pancreas.
The invading macrophages have the ability to act as antigen presenting cells and induce an autoimmune response against the vital tissue.
In contrast, the late administration of an immunogen can cause the release of lymphokines which may act as growth factors enabling autoimmune inducing cells to grown.
In preferred embodiments, the immunization schedules of the present invention may include employing initiating immunization prior to 28 days, supraimmunogenic doses, multiple doses prior to 56 or 112 days of age and/or dosing intervals of less than 28 days.
At least one non-pediatric immunogen(e.
g.
anthrax or plague immunogens) may be administered according to the present invention using similar immunization and dosing schedules to further strengthen the effect caused by administration of at least one pediatric immunogen described herein