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Method of inhibiting angiogenesis using secreted proteins
| Details |
Inventors: Jacobs, Kenneth; McCoy, John M.; Racie, Lisa A.; LaVallie, Edward R.; Merberg, David; Treacy, Maurice; Evans, Cheryl;
Assignee: Genetics Institute, Inc. (Cambridge, MA)
Primary Examiner: Carlson; Karen Cochrane
Assistant Examiner: Houze; Thomas A.
Attorney, Agent or Firm: Lahive & Cockfield, LLP, Lauro; Peter C., Mandragouras; Amy R.
Novel proteins are disclosed. |
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DETAILED DESCRIPTION Isolated Proteins Nucleotide and amino acid sequences, as presently determined, are reported below for each clone and protein disclosed in the present application.
The nucleotide sequence of each clone can readily be determined by sequencing of the deposited clone in accordance with known methods.
The predicted amino acid sequence (both full-length and mature) can then be determined from such nucleotide sequence.
The amino acid sequence of the protein encoded by a particular clone can also be determined by expression of the clone in a suitable host cell, collecting the protein and determining its sequence.
For each disclosed protein applicants have identified what they have determined to be the reading frame best identifiable with sequence information available at the time of filing.
As used herein a "secreted" protein is one which, when expressed in a suitable host cell, is transported across or through a membrane, including transport as a result of signal sequences in its amino acid sequence.
"Secreted" proteins include without limitation proteins secreted wholly (e.
g.
, soluble proteins) or partially (e.
g.
, receptors) from the cell in which they are expressed.
"Secreted" proteins also include without limitation proteins which are transported across the membrane of the endoplasmic reticulum.
Protein "AM931" One protein of, the present invention has been identified as protein "AM931".
A partial cDNA clone encoding AM931 was first isolated from a human fetal kidney cDNA library using methods which are selective for cDNAs encoding secreted proteins.
The nucleotide sequence of such partial cDNA was determined and searched against the GenBank and GeneSeq databases using BLASTN/BLASTX and FASTA search protocols.
The search revealed at least some identity with an EST identified as N30331 (yw75e04.
s1 Homo sapiens cDNA clone 258078 3'), R32076 (yh63e02.
r1 Homo sapiens cDNA clone 134426 5'), AA127732 (zk88b12.
r1 Soares pregnant uterus NbHPU Homo sapiens cDNA clone 489887 5'), and AA055091 (zf19g07
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Drugs 
