Mineralocorticoid receptor compositions and methods

Details

Inventors: Evans, Ronald M.; Weinberger, Cary A.; Giguere, Vincent; Arriza, Jeffrey; Thompson, Catherine C.; Ong, Estelita S.;
Assignee: The Salk Institute For Biological Studies (La Jolla, CA)
Primary Examiner: Ulm; John
Assistant Examiner:
Attorney, Agent or Firm: Pretty, Schoreder, Brueggemann & Clark, Reiter; Stephen E.

The present invention provides recombinant proteins having the hormone-binding and/or transcription-activating characteristics of a mineralocorticoid receptor. The invention also provides proteins expressed from recombinant DNA encoding a naturally occurring receptor having the hormone-binding and/or transcription-activating characteristics of a mineralocorticoid receptor.

DETAILED DESCRIPTION What is claimed is: 1.
Recombinant protein which has the amino acid sequence shown in FIGS.
36A to 36D, wherein said protein has hormone-binding and transcription activating properties characteristic of mineralocorticoid receptor.
2.
Protein according to claim 1 wherein said mineralocorticoid receptor is an avian or mammalian receptor.
3.
Protein according to claim 2 wherein said mineralocorticoid receptor is a mammalian receptor.
4.
Protein according to claim 3 wherein said mammalian receptor is a human mineralocorticoid receptor.
5.
Recombinant protein contained within a cell, wherein said protein is present in greater than endogenous amounts, wherein said protein is produced by expression of DNA capable of hybridizing with DNA encoding mineralocorticoid receptor protein having the amino acid sequence shown in FIGS.
36A to 36D under low stringency hybridization conditions, wherein said DNA encodes a naturally occurring receptor protein having hormone binding and/or transcription activating properties of a mineralocorticoid receptor.
6.
Protein according to claim 5 wherein said receptor protein has hormone binding and transcription-activating properties characteristic of mineralocorticoid receptor.
7.
A protein produced by expression of recombinant DNA encoding a natural occurring mineralocorticoid recombinant DNA encoding a natural occurring mineralocorticoid receptor proresin, wherein said DNA is capable of hybridizing, under non-stringent hybridization conditions, with the polynucleotide shown in FIGS.
36A to 36D.
8.
Protein according to claim 7 wherein said receptor protein has hormone binding and transcription-activating properties characteristic of mineralocorticoid receptor, and wherein said protein is encoded by DNA capable of hybridizing, under high stringency hybridization conditions, with a polynucleotide having the sequence shown in FIGS.
36A to 36D.

Description:
FIELD OF THE INVENTION The present invention relates to hormone receptor proteins and genes encoding them, modification of such receptors and genes by recombinant DNA and other genetic engineering techniques, plus uses of such receptors and genes, both unmodified and modified

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