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Neo-tryptophan
| Details |
Inventors: Richelson, Elliott; Cusack, Bernadette Marie; Pang, Yuan-Ping; McCormick, Daniel J.; Fauq, Abdul; Tyler, Beth Marie; Boules, Mona;
Assignee: Mayo Foundation for Medical Education and Research (Rochester, MN)
Primary Examiner: Russel; Jeffrey Edwin
Assistant Examiner:
Attorney, Agent or Firm: Fish & Richardson P.C.
The invention provides a novel amino acid, neo-tryptophan, as well as polypeptides containing this novel amino acid such as neurotensin analogs. In addition, the invention provides neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and polypeptides containing such derivatives. The invention also provides methods for making neo-tryptophan, neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and compositions containing these compounds. Further, the invention provides methods for inducing a neurotensin response in a mammal as well as methods for treating a mammal having a serotonin recognition molecule. |
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DETAILED DESCRIPTION What is claimed is: 1.
A method of making a neurotensin polypeptide containing neo-tryptophan, said method comprising: a) providing a neo-tryptophan derivative, and b) linking amino acid residues to said neo-tryptophan derivative to form said neurotensin polypeptide containing neo-tryptophan, wherein said neurotensin polypeptide comprises the sequence set forth in SEQ ID NOs:16 or 17.
2.
The method of claim 1, wherein said neurotensin polypeptide comprises the sequence set forth in SEQ ID NO:16.
3.
The method of claim 1, wherein said neurotensin polypeptide comprises the sequence set forth in SEQ ID NO:17.
4.
The method of claim 1, wherein said neo-tryptophan is L-neo-tryptophan.
5.
The method of claim 1, wherein said neo-tryptophan is D-neo-tryptophan.
6.
The method of claim 1, wherein said neo-tryptophan derivative comprises a blocking group.
7.
The method of claim 6, wherein said blocking group is Fmoc.
8.
The method of claim 6, wherein said blocking group is Boc.
Description:
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Drugs 
