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Osp A and B Sequence of Borrelia burgdonferi strains ACA1 and IP90
| Details |
Inventors: Barbour, Alan George; Bergstrom, Sven; Hansson, Lennart;
Assignee: Symbicom Aktiebolag (Umea, SE)
Primary Examiner: Elliott; George G.
Assistant Examiner: Fredman; Jeffrey
Attorney, Agent or Firm: Curtis, Morris & Safford, Kowalski; Thomas J.
Disclosed and claimed are isolated DNA molecules consisting of nucleotide sequences encoding or priming for ospA and/or ospB of various B. burgdorferi or portions thereof and methods of making and using the same. |
|
DETAILED DESCRIPTION We claim: 1.
An isolated DNA molecule consisting of a nucleotide sequence as shown in FIG.
3 for ACA1 (SEQ ID NO: 5), or a sequence exactly complementary thereto.
2.
An isolated DNA molecule consisting of a nucleotide sequence starting at nucleotide 37 and terminating at nucleotide FIG.
3 (SEQ ID NO: 4, nucleotides 127-948), for ACA1, the nucleotide numbering being based on the B31 numbering shown in FIG.
3, or a sequence exactly complementary thereto.
3.
An isolated DNA molecule consisting of a nucleotide sequence starting at nucleotide 867 and terminating at nucleotide 1877 of the nucleotide sequence shown in FIG.
3 (SEQ ID NO: 4, nucleotides 962-1860), for ACA1, the nucleotide numbering being based on the B31 numbering shown in FIG.
3, or a sequence exactly complementary thereto.
4.
An isolated DNA molecule consisting of a nucleotide sequence as shown in FIG.
3 (SEQ ID NO: 6) for Ip90 or a sequence exactly complementary thereto.
5.
An isolated DNA molecule consisting of a nucleotide sequence starting at nucleotide 37 and terminating at nucleotide 859 of the nucleotide sequence shown in FIG.
3 (SEQ ID NO: 7, nucleotides 125-949) for IP90, the nucleotide numbering being based on the B31 numbering shown in FIG.
3, or a sequence exactly complementary thereto.
6.
An isolated DNA molecule consisting of a nucleotide sequence starting at nucleotide 871 and terminating at nucleotide 1855 of the nucleotide sequence shown in FIG.
3 for Ip90, the nucleotide numbering being based on the B31 numbering shown in FIG.
3, or a sequence exactly complementary thereto.
7.
An isolate DNA molecule according to claim 1 or claim 4 which encodes a protein having a lipoprotein signal peptide recognised by signal peptidase II.
8.
An isolated DNA molecule according to claim 7 wherein the lipoprotein signal peptide has at least 10 amino acids.
9.
An isolated DNA molecule according to claim 8 wherein the lipoprotein signal peptide has from 16 to 35 amino acids.
10.
An isolated DNA molecule consisting of a nucleotide sequence which encodes 100 amino acids of OspA and/or OspB from one of strains ACA1 or Ip90 only, as shown in FIG
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