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Painless electrolyte solutions
| Details |
Inventors: Hustead, Robert E.; Hustead, David R.;
Assignee:
Primary Examiner: Dixon, Jr.; William R.
Assistant Examiner: Hunter, Jr.; James M.
Attorney, Agent or Firm: Saidman, Sterne, Kessler & Goldstein
This invention relates to compositions comprising electrolytes dissolved in a buffer which is painless when administered by irrigation. This invention also relates to compositions comprising a local anesthetic such as lidocaine, procaine, mepivacaine or marcaine, dissolved in a buffered solution containing salts which do not cause pain when the solutions are administered. The compositions are useful for administration as painless local anesthetics and painless irrigation-anesthetizing solutions for human and animal use. The invention further relates to methods for painless irrigation of wounds and of inducing painless local anesthesia comprising administering an effective amount of the compositions of this invention to an animal. |
|
DETAILED DESCRIPTION What is claimed is: 1.
A composition consisting of: (a) electrolytes selected from the group consisting of K.
sup.
+, Ca.
sup.
++, Na.
sup.
+ and Mg.
sup.
++ salts of anions, wherein said K.
sup.
+ is present at a concentration of 2-10 meq/L, said Ca.
sup.
++ is present at a concentration of 0-3 meq/L, said Mg.
sup.
++ is present at a concentration of 1-5 meq/L, and said Na.
sup.
+ is present at a concentration of 110-150 meq/L; and (b) a solution of pH 6.
85-8.
0; wherein said composition is painless when administered internally, ophthalmically or by irrigation of a wound, abrasion, laceration or burn, and wherein said solution is obtained by titrating aqueous acetic acid to pH 6.
85-8.
0 with aqueous sodium hydroxide and diluting to a final concentration of 110-150 meq/L Na.
sup.
+ and 80-125 meq/L Cl.
sup.
- or by titrating aqueous HCl to a pH of 6.
85-8.
0 with aqueous sodium acetate and diluting to a concentration of 110-150 meq/L Na.
sup.
+ and 80-125 meq/L Cl.
sup.
-.
2.
A composition comprising: (a) electrolytes selected from the group consisting of K.
sup.
+, Ca.
sup.
++, Na.
sup.
+ and Mg.
sup.
++ salts of anions, wherein said K.
sup.
+ is present at a concentration of 2-10 meq/L, said Ca.
sup.
++ is present at a concentration of 0-3 meq/L, said Mg.
sup.
++ is present at a concentration of 1-5 meq/L, and said Na.
sup.
+ is present at a concentration of 110-150 meq/L; and (b) a solution of pH 6.
85-8.
0; (c) one or more local anesthetics wherein said composition is painless when administered internally, ophthalmically or by irrigation of a wound, abrasion, laceration or burn.
3.
The composition of claim 2, wherein said local anesthetic is selected from the group consisting of lidocaine, mepivacaine, bupivacaine, chloroprocaine, procaine, and proparacaine.
4.
The composition of claim 2, wherein the local anesthetic is a combination of anesthetics comprising mepivacaine and bupivacaine.
5.
A method for providing painless irrigation of a wound, abrasion, laceration or burn, comprising irrigation with a composition consisting of: (a) electrolytes selected from the group consisting of K
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