DETAILED DESCRIPTION We claim: 1.
A compound of the formula ##STR6## wherein each of R.
sub.
1, R.
sub.
2, R.
sub.
4, R.
sub.
5 and R.
sub.
6 is lower alkoxy; R.
sub.
3 is hydrogen or lower alkoxy; and R.
sub.
7 is lower alkyl or a diasterioisomer thereof or a pharmaceutically acceptable acid addition salt thereof.
2.
2-methyl-6, 7-dimethoxy-1-[4,5,6-triethoxy-7-amino-3-phthalidyl]-1,2,3,4-tetrahydro-iso quinoline.
3.
A compound of claim 1, wherein R.
sub.
1, R.
sub.
2, R.
sub.
3, R.
sub.
4, R.
sub.
5 and R.
sub.
6 are each independently methoxy or ethoxy.
4.
A compound of claim 1, wherein R.
sub.
7 is methyl.
5.
2-methyl-6,7,8-trimethoxy-1-[4,5,6-triethoxy-7-am ino-3-phthalidyl]-1,2,3,4-tetrahydro-isoquinoline.
6.
A pharmaceutical composition for inhibiting an allergic condition in a patient which comprises a compound of claim, 2, 1, 3 or 4 and a physiologically acceptable carrier or diluent.
7.
A pharmaceutical composition in dosage unit form for the treatment of allergies which comprises an effective amount of 2-methyl-6,7,8-trimethoxy-1-[4,5,6-triethoxy-7-amino-3-phthalidyl]-1,2,3,4 -tetrahydro-isoquinoline and a pharmaceutically acceptable carrier or diluent therefor.
8.
A pharmaceutical composition of claim 7, wherein said dosage unit is a tablet.
9.
A method for retarding an allergic condition in a patient which comprises administering to said patient an effective amount of a compound of claim 4 or 6.
Description:
The present invention relates to derivatives of phthalidyl-isoquinolines, their preparation, and their use as medicaments, in particular for treating allergy conditions.
Noscapine has been known for a long time, which is an alkaloid used on account of its antitussive properties.
A derivative structurally similar to this latter compound, namely tritoqualine (see French Pat.
No.
1 295 309) has been noted for its anti-allergy properties (HAHN et al, Arz.
Forsch.
20, 1490 (1970)).
It has now been found that new compounds of this type have a similar but even more useful activity, and may thus be used in therapeutics
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