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Polynucleotide encoding TNFL1
| Details |
Inventors: Tribouley, Catherine;
Assignee: Chiron Corporation (Emeryville, CA)
Primary Examiner: Spector; Lorraine
Assistant Examiner: O'Hara; Eileen B.
Attorney, Agent or Firm: Potter; Jane E. R., Morley; Kimberlin L., Blackburn; Robert P.
New members of the TNF and the TNFR superfamily of proteins have been identified. These proteins are promising targets for therapeutic intervention and mimesis. TNF-L and TNFR-L proteins can be used to induce cell death and/or proliferation of cells. Members of these superfamilies have been implicated in a broad variety of disease processes, making them central biological and physiological regulators. |
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DETAILED DESCRIPTION It is an object of the invention to provide new members of the TNF and TNFR families, as well as methods of screening for compounds capable of modifying the activities of these proteins.
This and other objects of the invention are provided by one or more of the embodiments described below.
One embodiment of the invention is an isolated human protein having an amino acid sequence which is at least 85% identical to an amino acid sequence selected from the group consisting of SEQ ID NOS:1, 2, 17 and 20.
Percent identity is determined using a Smith-Waterman homology search algorithm using an affine gap search with a gap open penalty of 12 and a gap extension penalty of 1.
Another embodiment of the invention is a fusion protein comprising a first protein segment and a second protein segment fused together by means of a peptide bond.
The first protein segment consists of a protein having an amino acid sequence selected from the group consisting of SEQ ID NOS:1, 2, 17 and 20.
Still another embodiment of the invention is a preparation of antibodies which specifically bind to a protein having an amino acid sequence selected from the group consisting of SEQ ID NOS: 1, 2, 17 and 20.
Even another embodiment of the invention is a cDNA molecule which encodes a protein having an amino acid sequence which is at least 85% identical to an amino acid sequence selected from the group consisting of SEQ ID NOS: 1, 2, 17 and 20.
Percent identity is determined using a Smith-Waterman homology search algorithm using an affine gap search with a gap open penalty of 12 and a gap extension penalty of 1.
Yet another embodiment of the invention is a cDNA molecule which is at least 85% identical to a nucleotide sequence selected from the group consisting of SEQ ID NOS:6, 7, 18 and 19.
Percent identity is determined using a Smith-Waterman homology search algorithm using an affine gap search with a gap open penalty of 12 and a gap extension penalty of 1.
A further embodiment of the invention is an isolated and purified subgenomic polynucleotide comprising a nucleotide sequence which hybridizes to a nucleotide sequence selected from the group consisting of SEQ ID NOS:6, 7, 18 and 19 after washing with 0
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