 Anti hepatitis C virus antibody and uses thereof |
| OF THE PRESENT INVENTION Accordingly, the technical problem of the invention is to provide means ... |
|
| Chemical and/or biological decontamination system |
| OF THE INVENTION The present invention provides a composition that is effective in the ... |
|
| Immunostimulant bacterial membrane fractions in cancer treatment |
| The invention claimed is: 1. A method of stimulating an immune response and/or inducing an ... |
|
| Cloning and characterization of a human adenylyl cyclase |
| One aspect of the invention is an isolated and purified human type VI adenylyl cyclase (hAC6) ... |
|
| Tumor antigen based on products of the tumor suppressor gene WT1 |
| What is claimed is: 1. An isolated polypeptide which consists of at most 12 contiguous amino acid ... |
|
| Methods of inhibiting GPR-9-6 function |
| The invention relates to an antibody (immunoglobulin) or functional fragment thereof (e.g., an ... |
|
| Method for cloning of a rare, specifically mutated cell |
| The invention is a new and improved method for reliably detecting the presence of a rare cell ... |
|
| Vaccine against Gram-negative bacterial infections |
| OF THE PREFERRED EMBODIMENTS According to the present invention, a non-covalent, polyvalent ... |
|
| Inhibitor of stem cell proliferation and uses thereof |
| The present invention relates to polypeptides which are inhibitors of stem cell proliferation ("INPR... |
|
|
Polypeptide and protein derivatives and process for their preparation
| Details |
Inventors: Offord, Robin Ewart; Rose, Keith;
Assignee: Amylin Pharmaceuticals, Inc. (San Diego, CA)
Primary Examiner: Weber; Jon
Assistant Examiner: Mohamed; Abdel A.
Attorney, Agent or Firm: Edell, Shapiro & Finnan, LLC
Protein and polypeptid derivatives and their salts are claimed characterized in that a protein or polypeptide is conjugated via an intermediate grouping containing at least one radical of the formula --C(R).dbd.N-- (or --N.dbd.C(R)--) or --CH(R)--NH-- (or --NH--CH(R)--), wherein R is hydrogen or a hydrocarbon residue which may be substituted, with the same or a different protein or polypeptide, with a reporter group or a cytotoxic agent as well as a process for their preparation and the novel intermediates therefor. |
|
DETAILED DESCRIPTION What we claim is: 1.
A method of producing a composition containing modified protein or polypeptide molecules, or salts thereof, wherein said modified protein or polypeptide molecules of said composition consist essentially of a compound selected from A-X-Z-X'--B wherein A is a residue of a protein or polypeptide having a carboxy and amino terminus and is connected to X-Z-X'--B exclusively at said carboxy or amino terminus; B is a polymeric compound; X and X' independently from each other are bivalent organic radicals or independently from each other are present or absent; Z is a bivalent radical selected from the group consisting of: --C(R).
dbd.
N--, --N.
dbd.
C(R)--, --CH(R)--NH--, --NH--CH(R)--, --C(R).
dbd.
N--Y--NC(R)--, --N.
dbd.
C(R)--Y--C(R)N--, --CH(R)--NH--Y--NH--CH(R)-- and --NH--CH(R)--Y--CH(R)--NH--, --C(R).
dbd.
N--O--, --O--N.
dbd.
C(R)--, --CH(R)--NH--O--, --O--NH--CH(R)--, --C(R).
dbd.
N--O--Y--O--N.
dbd.
C(R)--, --O--N.
dbd.
C(R)--Y--C(R).
dbd.
N--O--, --CH(R)--NH--O--Y--O--NH--CH(R)-- and --O--NH--CH(R)--Y--CH(R)--NH--O--; where R is hydrogen or an aliphatic, cycloaliphatic, aromatic or araliphatic hydrocarbon group; and Y is a bivalent organic group, wherein said method comprises condensing a compound of the formula: A-X--R.
sup.
1 wherein R.
sup.
1 is a --CO--R group, an acetalized formyl group, or an amino or protected amino group, and A,R, and X are as defined above, with a compound of formula: R.
sup.
2--X'--B or a compound of formula: R.
sup.
2--Y--R.
sup.
2 where R.
sup.
2 is amino when R.
sup.
1 is --CO--R or acetalized formyl and R2 is --CO--R or acetalized formyl when R.
sup.
1 is amino, and X', Y, R and B are as defined above, to form a Schiff base, hydrazone, oxime or azomethine compound, and optionally, reducing the --C(R).
dbd.
N-- or --N.
dbd.
C(R) formed by the condensation to CH(R)--NH-- or NH--CH(R)--, respectively, and optionally forming a salt.
2.
The method of producing a composition of claim 1, wherein said residue A is a carboxy terminal residue.
3.
The method of producing a composition of claim 1, wherein said residue A is an amino terminal residue
|
| Related patents |
|
|
Single chain MHC complexes and uses thereof
The present invention relates to novel complexes of major histocompability complex (MHC) molecules (class I or II), e.g., empty single chain MHC class II complexes, ...
|
|
|
IL-1/TNF-.alpha.-activated kinase (ITAK), and methods of making and using the same
The present invention provides nucleic acid and amino acid sequences of protein kinases, preferably human, that interact with at least one post-receptor intracellular ...
|
|
|
DNA encoding IL-1 receptor accessory protein
What is claimed is: 1. An isolated polynucleotide comprising SEQ ID NO:1 wherein the nucleic acid at 1792 is A or C. 2. An isolated polynucleotide comprising a nucleic ...
|
|
|
Human immunodeficiency virus immunogenic composition
The present invention relates to an HLA-based vaccine against HIV. Vaccines of the invention, which induce salutary anti-HIV immune responses, can be designed based on ...
|
|
|
Recombinant molecule encoding human protease nexin
We claim: 1. An isolated DNA molecule which encodes mature protease nexin-I (PN-I) alpha of FIG. 3 or PN-I beta of FIG. 4 or encodes a PN-I protein encoded by a gene ...
|
|
|
Method for design of substances that enhance memory and improve the quality of life
I claim: 1. Each of the compounds Gln Phe Phe-.gamma.-aminobutyric acid (SEQ ID NO: 20) Gln Phe Phe-.beta.-alanine (SEQ ID NO: 21) Gln Phe Phe-.delta.-aminovaleric acid (...
|
|
|
Amyloid .beta. protein (globular assembly and uses thereof)
What is claimed is: 1. An isolated, soluble, non-fibrillar amyloid .beta. protein assembly comprising 3-12 amyloid .beta. proteins, wherein the amyloid .beta. protein is ...
|
|
|
Chlamydia antigens and corresponding DNA fragments and uses thereof
The present invention provides purified and isolated polynucleotide molecules that encode the Chlamydia polypeptide designated 76 kDa protein (SEQ ID No: 1) which can be ...
|
|
|
Methods of treating inflammatory bowel disease using cholera toxin B subunit
What is claimed is: 1. A method of treating inflammatory bowel disease in a subject diagnosed with inflammatory bowel disease, comprising administering to the subject a ...
|
|
|
Mammalian haemoglobin compatible with blood plasma, cross-linked and conjugated with polyalkylene oxides as artificial medical oxygen carriers, production and use thereof
1. Hemoglobin derivative compatible with human and non-human animal plasma, comprising hemoglobin crosslinked by means of a crosslinker for proteins and a polyalkylene ...
|
|
|
Drugs 
