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Semaphorin gene: Semaphorin Y
| Details |
Inventors: Kimura, Toru; Kikuchi, Kaoru;
Assignee: Sumitomo Pharmaceuticals Company, Limited (Osaka-fu, JP)
Primary Examiner: Baker; Anne-Marie
Assistant Examiner:
Attorney, Agent or Firm: Birch, Stewart, Kolasch & Birch, LLP
Semaphorin Y inhibiting neurite outgrowth, and a nucleotide sequence therefor, as well as other Semaphorin sequences hybridizing to the Semaphorin Y sequence, modified proteins or partial peptides of Semaphorin Y, antibodies against Semaphorin Y, antisense nucleotides against Semaphorin Y gene, and the use of such substances as pharmaceutical or diagnostic agents or laboratory reagents are disclosed. Further, a method of screening for Semaphorin Y antagonists employing Semaphorin Y, Semaphorin Y antagonists obtained by the screening method, pharmaceutical agents comprising such antagonists, and transgenic animals involving Semaphorin Y are also disclosed. |
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DETAILED DESCRIPTION What is claimed is: 1.
An isolated nucleic acid molecule comprising a polynucleotide having a nucleotide sequence selected from the group consisting of: (a) the nucleotide sequence of SEQ ID NO: 1, (b) the nucleotide sequence of SEQ ID NO: 2, (c) the nucleotide sequence of SEQ ID NO: 4, (d) the nucleotide sequence of SEQ ID NO: 5, (e) a cDNA sequence encoding the amino acid sequence of SEQ ID NO:3, and (f) a cDNA sequence encoding the amino acid sequence of SEQ ID NO: 6.
2.
The isolated nucleic acid molecule of claim 1 that originates from a mammal.
3.
A vector comprising the nucleic acid molecule of any one of claim 1 or 2.
4.
A host cell comprising the vector of claim 3.
5.
A process for producing a recombinant protein, comprising culturing the host cell of claim 4 under conditions sufficient for the production of said protein and recovering said protein.
6.
An isolated polynucleotide comprising at least 18 contiguous nucleotides of the sequence of SEQ ID NO: 1 or SEQ ID NO: 4, with the proviso that said polynucleotide does not consist of at least 18 contiguous nucleotides of the sequence of the polynucleotide of GenBank Accession NO: R59527.
7.
An isolated polynucleotide complementary to the polynucleotide of claim 6.
Description:
TECHNICAL FIELD The present invention relates to Semaphorin Y, a novel Semaphorin belonging to the Semaphorin family, and use of Semaphorin Y for pharmaceutical or diagnostic agents or laboratory reagents.
More particularly, it relates to Semaphorin Y inhibiting neurite outgrowth, and a gene therefor, as well as other Semaphorins hybridizing to said Semaphorin Y gene, modified proteins or partial peptides of said Semaphorin Y, antibodies against said Semaphorin Y, antisense nucleotides against said Semaphorin Y gene, antagonists of said Semaphorin Y, transgenic animals, and their use as pharmaceutical or diagnostic agents or laboratory reagents.
BACKGROUND ART It is widely known that a central nervous system (CNS)-neuron in higher organisms such as human is not capable of regeneration once injured
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