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Silver halide emulsions with recombinant collagen suitable for photographic application and also the preparation thereof
| Details |
Inventors: Van Heerde, George Valentino; Van Rijn, Alexis Cornelus; Bouwstra, Jan Bastiaan; De Wolf, Frederik Anton; Mooibroek, Andreas; Werten, Marc Willem Theodoor; Wind, Richele Deodata; Van Den Bosch, Tanja Jacoba;
Assignee: Fuji Photo Film B.V. (Tilburg, NL)
Primary Examiner: Le; Hoa Van
Assistant Examiner:
Attorney, Agent or Firm: Nixon and Vanderhye PC
A tabular silver halide emulsion wherein the tabular grains account for more than 75% of the total grain projected area said emulsion comprising silver halide grains nucleated in the presence of nucleation peptizer and thereafter grown in the presence of growth peptizer, wherein at least one of the peptizers is substantially pure collagen like material prepared by genetic engineering, said peptizer having an amino acid sequence comprising more than 4 different amino acids. A process of preparing the AgX emulsion. A process of producing recombinant collagen like polypeptide comprising expression of a collagen like polypeptide encoding nucleic acid sequence by a microorganism to a degree exceeding 0.95 grammes/liter, said recombinant collagen being free of helix structure and preferably the expression occurring in a microorganism other than E. coli or Saccharomyces cerevisiae. |
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DETAILED DESCRIPTION What is claimed is: 1.
A tabular silver halide emulsion wherein the tabular grains account for more than 75% of the total grain projected area said emulsion comprising silver halide grains nucleated in the presence of a nucleation peptizer and thereafter grown in the presence of a growth peptizer, wherein at least one of the peptizers is substantially pure collagen like materials prepared by genetic engineering, said peptizer having an amino acid sequence comprising more than 4 different amino acids.
2.
An emulsion according to claim 1, said peptizer having an amino acid sequence comprising more than 10 amino acids that are different.
3.
A emulsion according to claim 1 wherein the amino acid sequence of the peptizer exhibits more than 40% homology with native collagen.
4.
An emulsion according to claim 1 said peptizer having an amino acid sequence which is at least 80% identical to naturally occurring collagen.
5.
An emulsion according to claim 1, wherein the peptizer has an amino acid sequence of naturally occurring collagen comprising 0-5 amino acid mutations.
6.
An emulsion according to claim 1, wherein the peptizer is substantially pure collagen like material prepared by native collagen encoding nucleic acid.
7.
An emulsion according to claim 1, wherein the peptizer has an amino acid sequence substantially the same as occurs in nature for collagen type I, II or III.
8.
An emulsion according to claim 1, wherein the peptizer has an amino acid sequence equivalent to the amino acid sequence occurring in nature for collagen type I, II or III.
9.
An emulsion according to claim 1, wherein the peptizer has an amino acid sequence the same as occurs in nature for collagen type I, II or III.
10.
An emulsion according to claim 1, wherein the collagen is collagen type I which comprises or has the amino acid sequence of FIGS.
8, 10 or 12 or Genbank accession number U08020.
11.
An emulsion according to claim 1, wherein the collagen is collagen type III which comprises or has the amino acid sequence of FIG
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Drugs 
