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Synthetic-peptides-and-kits-for-diagnosis-of-anti-phospholipid-syndrome

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Synthetic peptides and kits for diagnosis of anti-phospholipid syndrome

Details

Inventors: Blank, Miri; Cabilly, Shmuel; Shoenfeld, Yehuda; Katchalski-Katzir, Ephraim;
Assignee: Yeda Research Development Co., LTD (Rehovot, IL)
Primary Examiner: Lukton; David
Assistant Examiner:
Attorney, Agent or Firm: Browdy and Neimark PLLC

Synthetic peptides and derivatives thereof capable of inhibiting the biological activity of anti-beta-2-glycoprotein 1 (.beta.2GPI) monoclonal antibodies (mAbs) in vitro, and of inhibiting induction of experimental anti-phospholipid syndrome (APS) in mice by anti-.beta.2GPI mAbs, are provided for the diagnosis and treatment of anti-phospholipid syndrome in humans.

DETAILED DESCRIPTION The invention claimed is: 1.
A synthetic peptide selected from the group consisting: (i) a peptide of SEQ ID NO:1 to SEQ ID NO: 7, of the sequences: Leu-Lys-Thr-Pro-Arg-Val (SEQ ID NO:1); Lys-Thr-Pro-Arg-Val-Thr (SEQ ID NO:2); Asn-Thr-Leu-Lys-Thr-Pro-Arg-Val-Gly-Gly (SEQ ID NO: 3); Lys-Asp-Lys-Ala-Thr-Phe-Gly-Thr-His-Asp-Gly (SEQ ID NO:4); Thr-Lys-Leu-Arg-Val-Tyr (SEQ ID NO:5); Thr-Leu-Leu-Arg-Val-Tyr (SEQ ID NO:6); and Cys-Ala-Thr-Leu-Arg-Val-Tyr-Lys-Gly-Gly (SEQ ID NO:7), and (ii) a peptide of (i) that is biotinylated.
2.
The peptide according to claim 1 of SEQ ID NO:1.
3.
The peptide according to claim 1 of SEQ ID NO:4.
4.
The peptide according to claim 1 of SEQ ID NO:7.
5.
The peptide according to claim 1 (ii) that is biotinylated.
6.
The peptide according to claim 5, wherein the peptide is a peptide of SEQ ID NO:1 that is biotinylated.
7.
The peptide according to claim 5, wherein the peptide is a peptide of SEQ ID NO:4 that is biotinylated.
8.
The peptide according to claim 5, wherein the peptide is a peptide of SEQ ID NO:7 that is biotinylated.

Description:

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