 Coating head assembly for elongated strands |
| An object of the present invention is to provide a split coating head assembly for elongated ... |
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| Wafer heaters for use in semiconductor-producing apparatus and heating units using such wafer heaters |
| A first aspect of the present invention has been accomplished to solve the above-mentioned problems ... |
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| Thermal treatment with enhanced intra-wafer, intra-and inter-batch uniformity |
| It is an object of the present invention to provide novel heat treatment capable of shortening a ... |
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| Pipe cleaning using microwave energy |
| OF INVENTION Microwaves are a versatile form of energy that is applicable to enhance chemical ... |
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| Process for preparing L-carnitine from DL-carnitine |
| What is claimed is: 1. A process for preparing L-carnitine and salts thereof which comprises ... |
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| Building elements and their preparation |
| We claim: 1. An improved building material element having good mechanical properties comprising ... |
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| Desulfatohirudins, the preparation thereof and pharmaceutical compositions containing them |
| What is claimed is: 1. A desulfatohirudin of the formula I ##STR3## or of the formula II ##STR4## ... |
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| Primitive cell colony stimulating factors and lymphohematopoietic progenitor cells |
| We claim: 1. A suspension of mammalian, non-murine, non-human cells comprised of pluripotent ... |
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Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
| Details |
Inventors: Bishop, W. Robert; Doll, Ronald J.; Mallams, Alan K.; Njoroge, F. George; Petrin, Joanne M.; Piwinski, John J.; Wolin, Ronald L.; Taveras, Arthur G.; Remiszewski, Stacy W.;
Assignee: Schering Corporation (Kenilworth, NJ)
Primary Examiner: Rotman; Alan L.
Assistant Examiner:
Attorney, Agent or Firm: Jeanette; Henry C., Thompson; Paul A.
A method of inhibiting Ras function and therefore inhibiting cellular growth is disclosed. The method comprises the administration of a compound of Formula 1.0 ##STR1## Also disclosed are novel compounds of the formulas: ##STR2## Also disclosed are processes for making 3-substituted compounds of the Formulas 1.1, 1.2 and 1.3. Further disclosed are novel compounds which are intermediates in the processes for making the 3-substituted compounds of Formulas 1.1, 1.2, and 1.3. |
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DETAILED DESCRIPTION OF THE INVENTION As used herein, the following terms are used as defined below unless otherwise indicated: M.
sup.
+ -represents the molecular ion of the molecule in the mass spectrum; MH.
sup.
+ -represents the molecular ion plus hydrogen of the molecule in the mass spectrum; alkyl--(including the alkyl portions of alkoxy, alkylamino and dialkylamino)-represents straight and branched carbon chains and contains from one to twenty carbon atoms, preferably one to six carbon atoms; alkanediyl--represents a divalent, straight or branched hydrocarbon chain having from 1 to 20 carbon atoms, preferably 1 to 6 carbon atoms, the two available bonds being from the same or different carbon atoms thereof, e.
g.
, methylene, ethylene, ethylidene, --CH.
sub.
2 CH.
sub.
2 CH.
sub.
2 --, --CH.
sub.
2 CHCH.
sub.
3, --CHCH.
sub.
2 CH.
sub.
3, etc.
cycloalkyl--represents saturated carbocyclic rings branched or unbranched of from 3 to 20 carbon atoms, preferably 3 to 7 carbon atoms; heterocycloalkyl--represents a saturated, branched or unbranched carbocylic ring containing from 3 to 15 carbon atoms, preferably from 4 to 6 carbon atoms, which carbocyclic ring is interrupted by 1 to 3 hetero groups selected from --O--, --S-- or --NR.
sup.
10 -(suitable heterocycloalkyl groups including 2- or 3-THFyl, 2- or 3-tetrahydrothienyl, 2-, 3- or 4-piperidinyl, 2- or 3-pyrrolidinyl, 2- or 3-piperizinyl, 2- or 4-dioxanyl, etc.
); alkenyl-represents straight and branched carbon chains having at least one carbon to carbon double bond and containing from 2 to 12 carbon atoms, preferably from 2 to 6 carbon atoms and most preferably from 3 to 6 carbon atoms; alkynyl-represents straight and branched carbon chains having at least one carbon to carbon triple bond and containing from 2 to 12 carbon atoms, preferably from 2 to 6 carbon atoms; aryl (including the aryl portion of aryloxy, and aralkyl)-represents a carbocyclic group containing from 6 to 15 carbon atoms and having at least one aromatic ring (e.
g.
, aryl is a phenyl ring), with all available substitutable carbon atoms of the carbocyclic group being intended as possible points of attachment, said carbocyclic group being optionally substituted (e
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Drugs 
