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Tumor associated nucleic acids and uses therefor
| Details |
Inventors: Martelange, Valerie; De Smet, Charles; Boon-Falleur, Thierry;
Assignee: Ludwig Institute for Cancer Research (New York, NY)
Primary Examiner: McGarry; Sean
Assistant Examiner: Shibuya; Mark L.
Attorney, Agent or Firm: Wolf, Greenfield & Sacks, P.C.
The invention describes sdp3.8 tumor associated nucleic acids, including fragments and biologically functional variants thereof. Also included are polypeptides and fragments thereof encoded by such nucleic acids, and antibodies relating thereto. Methods and products also are provided for diagnosing and treating conditions characterized by expression of a sdp3.8 gene product. |
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DETAILED DESCRIPTION OF THE INVENTION The examples which follow show the isolation of nucleic acid molecules which code for polypeptides and are expressed preferentially in tumor cells, i.
e.
which are tumor associated genes.
It is believed that the isolated nucleic acid molecules encode sdp3.
8 polypeptides because the nucleic acid molecules were initially isolated from expressed mRNA via RT-PCR amplification.
Hence, one aspect of the invention is an isolated nucleic acid molecule which includes all or a fragment of the nucleotide sequence set forth in SEQ ID NO:42.
This sequence does not encode a previously recognized tumor rejection antigen precursor, such as a MAGE, BAGE, GAGE, RAGE, LB33/MUM-1, PRAME, NAG, MAGE-Xp or brain glycogen phosphorylase sequence, as will be seen by comparing them to the sequence of any of the genes described in the references.
The invention thus involves in one aspect sdp3.
8 (HAGE) nucleic acids, encoded polypeptides, functional modifications and variants of the foregoing, useful fragments of the foregoing, as well as therapeutics and diagnostics related thereto.
The invention provides nucleic acid molecules which can code for a sdp3.
8 polypeptide and which hybridize under stringent conditions to a nucleic acid molecule consisting of the nucleotide sequence set forth in SEQ ID NO:42.
Such nucleic acids are termed tumor associated polypeptide precursors, and may be DNA, RNA, or composed of mixed deoxyribonucleotides and ribonucleotides.
The tumor associated polypeptide precursors can also incorporate synthetic non-natural nucleotides.
The invention thus encompasses other tumor associated nucleic acids, some of which may be expressed in normal tissues.
A tumor associated nucleic acid or polypeptide is a nucleic acid or polypeptide expressed preferentially in cancer cells, such as tumors including sarcomas, carcinomas, etc.
Various methods for determining the expression of a nucleic acid and/or a polypeptide in normal and tumor cells are known to those of skill in the art and are described further below
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Drugs 
