Home | Links | Contact Us | More About Intellectual Property | Bookmark
Search patents:
Home Drugs Vaccines

 Exchangeable template reaction
OF THE INVENTION Description of the Exchangeable Template Reaction (ETR) mechanism. The ETR is a ...


 Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
As has been discussed supra, it is desirable to produce human immunoglobulins that are reactive ...


 Transgenic non-human animals capable of producing heterologous antibodies
The design of a transgenic non-human animal that responds to foreign antigen stimulation with a ...


 Transgenic non-human animals capable of producing heterologous antibodies
As has been discussed supra, it is desirable to produce human immunoglobulins that are reactive ...


 Transgenic non-human animals for producing heterologous antibodies
As has been discussed supra, it is desirable to produce human immunoglobulins that are reactive ...


 Nucleic acids encoding lymphoid CD30 antigen
We claim: 1. An isolated nucleic acid molecule comprising a polynucleotide having a sequence ...


 Feeding tray for multiwell test apparatus
This invention will be described herein with reference to the growing and use of cells on a ...


 Neo-tryptophan
What is claimed is: 1. A method of making a neurotensin polypeptide containing neo-tryptophan, said ...


 Human immunodeficiency virus decoy
OF THE INVENTION The present invention has wide application to immunologic procedures and methods ...


 Capsid forming and cystein modified chimaeric MS2-coat protein
We claim: 1. A modified coat protein capable of forming a capsid which comprises the coat protein ...


 Vaccines

Details
Inventors: Friede, Martin; Garcon, Nathalie; Gerard, Catherine Marie Ghislaine; Hermand, Philippe;
Assignee: SmithKline Beecham Biologicals s.a. (Rixensart, BE)
Primary Examiner: Scheiner; Laurie
Assistant Examiner:
Attorney, Agent or Firm: Sutton; Jeffery A., Venetianer; Stephen, Kinzig; Charles M.

The present invention relates to adjuvant compositions which are suitable to be used in vaccines. In particular, the adjuvant compositions of the present invention comprises a saponin and an immunostimulatory oligonucleotide, optionally with a carrier. Also provided by the present invention are vaccines comprising the adjuvants of the present invention and an antigen. Further provided are methods of manufacture of the adjuvants and vaccines of the present invention and their use as medicaments. Methods of treating an individual susceptible to or suffering from a disease by the administration of the vaccines of the present invention are also provided.

DETAILED DESCRIPTION What is claimed is: 1.
An adjuvant composition comprising a QS21 and an immunostimulatory oligonucleotide containing an unmethylated CG dinucleotide.
2.
An adjuvant composition according to claim 1 further comprising a carrier.
3.
An adjuvant composition as claimed in claim 1, wherein said immunostimulatory oligonucleotide comprises a Purine, Purine, C, G, pyrimidine, pyrimidine sequence.
4.
An adjuvant composition as claimed in claim 1, wherein said immunostimulatory oligonucleotide is selected from the group comprising: TCC ATG ACG TTC CTG ACG TT (SEQ ID NO:1); TCT CCC AGC GTG CGC CAT (SEQ ID NO:2); ACC GAT GAC GTC GCC GGT GAC GGC ACC ACG (SEQ ID NO:3); TCG TCG TTT TGT CGT TTT GTC GTT (SEQ ID NO:4); TCC ATG ACG TTC CTG ATG CT (SEQ ID NO:5).
5.
An adjuvant composition as claimed in claim 1, wherein the immunostimulatory oligonucleotide contains at least two unmethylated CG repeats being separated at least by 3 nucleotides.
6.
An adjuvant composition according to claim 5, wherein the immunostimulatory oligonucleotide contains at least two unmethylated CG repeats being separated by 6 nucleotides.
7.
An adjuvant composition as claimed in claim 2, wherein said carrier is a particulate carrier selected from the group comprising metallic salt particles, emulsions, polymers, liposomes, ISCOMs.
8.
An immunogenic composition comprising an adjuvant composition as claimed in claims 1 or 2, further comprising an antigen.
9.
An immunogenic composition as claimed in claim 8, wherein said antigen is derived from an organism selected from the group comprising: Human Immunodeficiency Virus, Varicella Zoster virus, Herpes Simplex Virus type 1, Herpes Simplex virus type 2, Human cytomegalovirus, Dengue virus, Hepatitis A, B, C or E, Respiratory Syncytial virus, human papilloma virus, Influenza virus, Hib, Meningitis virus, Salmonella, Neisseria, Borrelia, Chlamydia, Bordetella, Streptococcus, Mycoplasma, Mycobacteria, Haemophilus, Plasmodium or Toxoplasma, stanworth decapeptide; or the N terminal 39-43 amino acid fragment (Abeta) of the amyloid precursor protein or antigens associated with atheroschlerosis



Related patents
  Preservation of bioactive materials by freeze dried foam
The present invention includes methods and compositions for preserving bioactive materials in storage. The methods generally provide, e.g., processes of expanding a ...
  Enhancement of intracellular delivery and tissue targeting of drugs and genes
OF THE INVENTION Streptavidin (SA) is a tetrameric protein possessing four high affinity binding sites for biotin. Chemical derivatives of biotin developed during the ...
  Methods and compositions useful in the diagnosis and treatment of autoimmune diseases
It is an object of this invention to provide a method for producing a protein antigen which is reactive with an autoantibody associated with an autoimmune disease. It is ...
  Method for the culture of microorganisms of the genera helicobacter, campylobacter and arcobacter employing culture media comprising cyclodextrins
It has been surprisingly discovered, and it makes the object of the present invention, that culture media wherein blood and its derivatives are, at least partially, ...
  Purified vacuolating toxin from Helicobacter pylori and methods to use same
It is an object of the present invention to provide a substantially pure antigenic composition with vacuolating toxin activity. It is an object of the present invention ...
  Process for preparation of a microbial agent
I claim: 1. A microbial control agent made by the process of: isolating Chilodonella uncinata; colonizing Chilodonella uncinata under laboratory conditions using ...
  Product of infectious respiratory syncytial virus from cloned nucleotide sequences
The present invention provides an isolated infectious RSV particle which comprises a recombinant RSV genome or antigenome, a nucleocapsid (N) protein, a nucleocapsid ...
  Protein tyrosine kinase substrate LAT and its use in the indentification of (ant)agonists of the kinase
OF SPECIFIC EMBODIMENTS Generally, the nomenclature used hereafter and the laboratory procedures in cell culture, molecular genetics, and nucleic acid chemistry and ...
  Biodegradable and biocompatible polymeric microspheres encapsulating Salmonella enteritidis bacteria
In accordance with the present invention, there are provided long term release, biocompatible and biodegradable, porous, polymeric microcapsules comprising whole killed S...
  Method for producing yeast expressed HPV types 6 and 16 capsid proteins
What is claimed is: 1. A virus-like particle (VLP) comprising a first late 1 (L1) capsid protein from human papilloma virus (HPV) type 6 and a second L1 capsid protein ...

0.014

Archive: All patents - Links

Copyright (c)2006 Eipa-patents.org - All rights reserved