Vaccines
What is claimed is: 1. An adjuvant composition comprising a QS21 and an immunostimulatory oligonucleotide containing an unmethylated CG dinucleotide. 2. An adjuvant composition according to claim 1 fu... Read More
Inventors: Friede, Martin; Garcon, Nathalie; Gerard, Catherine Marie Ghislaine; Hermand, Philippe;, Assignee: SmithKline Beecham Biologicals s.a. (Rixensart, BE) |
Preservation of bioactive materials by freeze dried foam
The present invention includes methods and compositions for preserving bioactive materials in storage. The methods generally provide, e.g., processes of expanding a formulation of the bioactive materi... Read More
Inventors: Truong-Le, Vu;, Assignee: MedImmune Vaccines, Inc. (Mountain View, CA) |
Enhancement of intracellular delivery and tissue targeting of drugs and genes
OF THE INVENTION Streptavidin (SA) is a tetrameric protein possessing four high affinity binding sites for biotin. Chemical derivatives of biotin developed during the last two decades allow covalent ... Read More
Inventors: Muzykantov, Vladimir R.; Albelda, Steve M.;, Assignee: Trustees of the University of Pennsylvania (Philadelphia, PA) |
Methods and compositions useful in the diagnosis and treatment of autoimmune diseases
It is an object of this invention to provide a method for producing a protein antigen which is reactive with an autoantibody associated with an autoimmune disease. It is a further object of this inven... Read More
Inventors: Keene, Jack D.;, Assignee: Duke University (Durham, NC) |
Method for the culture of microorganisms of the genera helicobacter, campylobacter and arcobacter employing culture media comprising cyclodextrins
It has been surprisingly discovered, and it makes the object of the present invention, that culture media wherein blood and its derivatives are, at least partially, replaced by cyclodextrins, enable t... Read More
Inventors: Figura, Natale; Bugnoli, Massimo; Olivieri, Roberto; Rappuoli, Rino;, Assignee: Chiron S.p.A. (IT) |
Purified vacuolating toxin from Helicobacter pylori and methods to use same
It is an object of the present invention to provide a substantially pure antigenic composition with vacuolating toxin activity. It is an object of the present invention to provide a purified antigenic... Read More
Inventors: Cover, Timothy L.; Blaser, Martin J.;, Assignee: Vanderbilt University (Nashville, TN) |
Process for preparation of a microbial agent
I claim: 1. A microbial control agent made by the process of: isolating Chilodonella uncinata; colonizing Chilodonella uncinata under laboratory conditions using artificial media; submerging said Chio... Read More
Inventors: Das, Bina Pina;, Assignee: National Institute of Communicable Diseases (Delhi, IN) |
Product of infectious respiratory syncytial virus from cloned nucleotide sequences
The present invention provides an isolated infectious RSV particle which comprises a recombinant RSV genome or antigenome, a nucleocapsid (N) protein, a nucleocapsid phosphoprotein (P), a large (L) po... Read More
Inventors: Collins, Peter L.;, Assignee: The United States of America as represented by the Department of Health and (Washington, DC) |
Protein tyrosine kinase substrate LAT and its use in the indentification of (ant)agonists of the kinase
OF SPECIFIC EMBODIMENTS Generally, the nomenclature used hereafter and the laboratory procedures in cell culture, molecular genetics, and nucleic acid chemistry and hybridization described below are ... Read More
Inventors: Samelson, Lawrence E.; Zhang, Weiguo;, Assignee: The United States of America as represented by the Department of Health and Human Services (Washington, DC) N/A ( |
Biodegradable and biocompatible polymeric microspheres encapsulating Salmonella enteritidis bacteria
In accordance with the present invention, there are provided long term release, biocompatible and biodegradable, porous, polymeric microcapsules comprising whole killed S. enteritidis bacteria. Upon a... Read More
Inventors: Yang, Yi-Yan; Kwang, Jimmy; Chen, Xueqin; Chung, Tai-Shung; Liu, Wei;, Assignee: Agency for Science, Technology and Research (Centros, SG) |
Method for producing yeast expressed HPV types 6 and 16 capsid proteins
What is claimed is: 1. A virus-like particle (VLP) comprising a first late 1 (L1) capsid protein from human papilloma virus (HPV) type 6 and a second L1 capsid protein from HPV type 16. 2. The VLP of... Read More
Inventors: Buonamassa, Daniela Tornese; Greer, Catherine E.; Galeotti, Cesira L.; Bensi, Giuliano; Petracca, Roberto;, Assignee: Chiron Corporation (Emeryville, CA) |
Exchangeable template reaction
OF THE INVENTION Description of the Exchangeable Template Reaction (ETR) mechanism. The ETR is a method for the synthesis of long polynucleotide DNA fragments using short synthetic oligonucleotides a... Read More
Inventors: Khudyakov, Yury; Fields, Howard A.;, Assignee: The United States of America as represented by the Department of Health (Washington, DC) |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
As has been discussed supra, it is desirable to produce human immunoglobulins that are reactive with specific human antigens that are promising therapeutic and/or diagnostic targets. However, produci... Read More
Inventors: Lonberg, Nils; Kay, Robert M.;, Assignee: GenPharm International (Mountain View, CA) |
Transgenic non-human animals capable of producing heterologous antibodies
The design of a transgenic non-human animal that responds to foreign antigen stimulation with a heterologous antibody repertoire, requires that the heterologous immunoglobulin transgenes contained wi... Read More
Inventors: Lonberg, Nils; Kay, Robert M.;, Assignee: GenPharm International, Inc. (Mountain View, CA) |
Transgenic non-human animals capable of producing heterologous antibodies
As has been discussed supra, it is desirable to produce human immunoglobulins that are reactive with specific human antigens that are promising therapeutic and/or diagnostic targets. However, produci... Read More
Inventors: Lonberg, Nils; Kay, Robert M.;, Assignee: GenPharm International, Inc. (Palo Alto, CA) |
Transgenic non-human animals for producing heterologous antibodies
As has been discussed supra, it is desirable to produce human immunoglobulins that are reactive with specific human antigens that are promising therapeutic and/or diagnostic targets. However, produci... Read More
Inventors: Lonberg, Nils; Kay, Robert M.;, Assignee: GenPharm International Inc. (Palo Alto, CA) |
Nucleic acids encoding lymphoid CD30 antigen
We claim: 1. An isolated nucleic acid molecule comprising a polynucleotide having a sequence encoding the amino acid sequence of SEQ. ID. NO.: 2. 2. A recombinant vector comprising an isolated nucleic... Read More
Inventors: Stein, Harald; Durkop, Horst; Latza, Ute;, Assignee: |
Feeding tray for multiwell test apparatus
This invention will be described herein with reference to the growing and use of cells on a membrane positioned and secured to the bottom of each of a multiplicity of wells. However, it is to be under... Read More
Inventors: Pitt, Aldo; Rising, Donald; DeSilets, Kenneth;, Assignee: Millipore Corporation (Billerica, unknown) |
Neo-tryptophan
What is claimed is: 1. A method of making a neurotensin polypeptide containing neo-tryptophan, said method comprising: a) providing a neo-tryptophan derivative, and b) linking amino acid residues to s... Read More
Inventors: Richelson, Elliott; Cusack, Bernadette Marie; Pang, Yuan-Ping; McCormick, Daniel J.; Fauq, Abdul; Tyler, Beth Marie; Boules, Mona;, Assignee: Mayo Foundation for Medical Education and Research (Rochester, MN) |
Human immunodeficiency virus decoy
OF THE INVENTION The present invention has wide application to immunologic procedures and methods wherein antigenic material or other biologically active moieties are utilized. These areas of applica... Read More
Inventors: Kossovsky, Nir; Gelman, Andrew E.; Sponsler, Edward E.;, Assignee: The Regents of the University of California (Oakland, CA) |
Capsid forming and cystein modified chimaeric MS2-coat protein
We claim: 1. A modified coat protein capable of forming a capsid which comprises the coat protein of a bacteriophage selected from the group consisting of MS-2, R17 and fr, wherein the coat protein is... Read More
Inventors: Mastico, Robert Allan; Stockley, Peter George;, Assignee: British Technology Group Ltd. (GB2) |
Polynucleotides related to monoclonal antibody 1A7 and use for the treatment of melanoma and small cell carcinoma
This invention relates to the discovery of an anti-idiotype antibody that is capable of recruiting a tumor-specific response against GD2. The antibody is designated 1A7. The immune response elicited ... Read More
Inventors: Chatterjee, Malaya; Foon, Kenneth A.; Chatterjee, Sunil K.;, Assignee: Board of Trustees of the University of Kentucky (Lexington, KY) |
Strategically modified hepatitis B core proteins and their derivatives
The present invention relates to a strategically modified hepatitis B core (HBc) protein that is linked to a pendent hapten through chemically-reactive amino acid residue inserted into the HBc sequenc... Read More
Inventors: Birkett, Ashley J.;, Assignee: Immune Complex Corporation (San Diego, CA) |
Chimeric biotin-binding papillomavirus protein
OF THE INVENTION The first domain of the chimeric protein includes at least a portion of a papillomavirus L1 or L2 protein. The sequence of the L1 and L2 proteins of many papillomaviruses is known, a... Read More
Inventors: Mueller, Martin; Nieland, John D.; Velders, Markwin P.; Kast, W. Martin;, Assignee: Loyola University of Chicago (Maywood, IL) |
Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell
OF THE INVENTION DEFINITIONS As used in this application, the following words or phrases have the meanings specified. As used herein, a "bispecific fusion protein" means any immunologically reactive ... Read More
Inventors: Ledbetter, Jeffrey A.; Gilliland, Lisa K.; Hayden, Martha S.; Linsley, Peter S.; Bajorath, Jurgen; Fell, H. Perry;, Assignee: Bristol-Myers Squibb Company (New York, NY) |
MYPPPY variants of CTL A4 and uses thereof
OF THE INVENTION Definition As used in this application, the following words or phrases have the meanings specified. As used herein "blocking B7 interaction" means to interfere with the binding of th... Read More
Inventors: Linsley, Peter S.; Ledbetter, Jeffrey A.; Peach, Robert;, Assignee: Bristol-Myers Squibb Company (Princeton, NJ) |
CTLA4 receptor and uses thereof
OF THE INVENTION DEFINITION As used in this application, the following words or phrases have the meanings specified. As used herein "blocking B7 interaction" means to interfere with the binding of th... Read More
Inventors: Linsley, Peter S.; Ledbetter, Jeffrey A.; Damle, Nitin K.; Brady, William; Kiener, Peter A.;, Assignee: Briston-Myers Squibb Company (Princeton, NJ) |
CTLA4/CD28Ig hybrid fusion proteins and uses thereof
OF THE INVENTION DEFINITION As used in this application, the following words or phrases have the meanings specified. As used herein "blocking B7 interaction" means to interfere with the binding of th... Read More
Inventors: Linsley, Peter S.; Ledbetter, Jeffrey A.; Bajorath, Jurgen; Peach, Robert; Brady, William;, Assignee: Bristol-Myers Squibb Company (Princeton, NJ) |
Method of regulating cellular processes mediated by B7 and CD28
Accordingly, the present invention identifies the B7 antigen as a ligand recognized by the CD28 receptor. The B7 antigen, or its fragments or derivatives are reacted with CD28 positive T cells to regu... Read More
Inventors: Linsley, Peter S.; Ledbetter, Jeffrey A.; Damle, Nitin K.; Brady, William;, Assignee: Bristol-Myers Squibb Company (Princeton, NJ) |
Methods of inhibiting T cell proliferation or IL-2 accumulation with CTLA4- specific antibodies
This invention is based, at least in part, on the discovery of novel ligands which bind a T cell surface molecule and induce antigen specific apoptosis in an activated T cell. Preferably, the ligand i... Read More
Inventors: Gribben, John G.; Freeman, Gordon J.; Nadler, Lee M.; Rennert, Paul; Jellis, Cindy L.; Greenfield, Edward; Gray, Gary S.;, Assignee: Repligen Corporation (Cambridge, MA); Dana-Farber Cancer Institute (Boston, MA) |
Drugs 
