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Results: 31-60 of 3116
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Method for generating and identifying antibodies directed against a B7
Accordingly, the present invention identifies the B7 antigen as a ligand recognized by the CD28 receptor. The B7 antigen, or its fragments or derivatives are reacted with CD28 positive T cells to regu... Read More
Inventors: Linsley, Peter S.; Ledbetter, Jeffrey A.; Damle, Nitin K.; Brady, William;, Assignee: Bristol-Myers Squibb Company (Princeton, NJ) |
Polypeptide that interacts with heat shock proteins
Described herein are the isolation and characterization of a polypeptide, particularly a tetratricopeptide repeat (TPR)-containing polypeptide that is an interactive partner with heat shock proteins. ... Read More
Inventors: Patterson, Winston Campbell; Ballinger, Carol A.;, Assignee: Board of Regents, The University of Texas System (Austin, TX) |
1,2-Biguanides
What is claimed is: 1. A substituted biguanide of the formula ##EQU8## wherein R.sub.1 is alkyl of 1-8 carbon atoms, R'.sub.1 is hydrogen or alkyl of 1-8 carbon atoms and R.sub.2 is alkoxyalkyl of 2-1... Read More
Inventors: Ahrens, Hanns; Rufer, Clemens; Biere, Helmut; Schroder, Eberhard; Losert, Wolfgang; Loge, Olaf; Schillinger, Ekkehard;, Assignee: Schering Aktiengesellschaft (Berlin & Bergkamen, DT) |
Biguanide salts
OF THE INVENTION The invention relates to biguanide salts. In another aspect, the invention relates to pharmaceutical preparations which contain the aforementioned biguanide salts. The biguanide salt... Read More
Inventors: Fischer, Ulf; Lorch, Eckehard;, Assignee: Hoffmann-La Roche Inc. (Nutley, NJ) |
Inhibitors of dipeptidyl-aminopeptidase type IV
What is claimed is: 1. A method for treating transplant rejection in a patient comprising administering to said patient an inhibitor of DP-IV, having the structure: ##STR16## wherein m is an integer b... Read More
Inventors: Bachovchin, William W.; Plaut, Andrew G.;, Assignee: New England Medical Center Hospitals, Inc. (Boston, MA); Tufts University (Medford, MA) |
Process for preparing anti-obesity protein
OF THE INVENTION For purposes of the present invention, as disclosed and claimed herein, the following terms and abbreviations are as defined below. dDAP--a dipeptidylaminopeptidase, isolated from Di... Read More
Inventors: MacKellar, Warren C.;, Assignee: Eli Lilly and Company (Indianapolis, IN) |
Use of GLP-1 or analogs to abolish catabolic changes after surgery
The present invention therefore presents for the first time a method of attenuating post-surgical catabolic changes and insulin resistance, comprising, administering to a patient in need thereof a com... Read More
Inventors: Efendic, Suad;, Assignee: Eli Lilly and Company (Indianapolis, IN) |
Effects of sporoderm-broken germination activated ganoderma spores on treatment of spinal cord injury
OF THE INVENTION The present invention provides a method for effective treatment of spinal cord injury. The method involves administering an effective amount of germination activated Ganoderma spore ... Read More
Inventors: Chung, Chee-Keung; Tong, Siu-Kan;, Assignee: Enhan Technology Holdings International Co., Ltd. (Kowloon, HK) |
Leptospira rare outer membrane proteins
The present invention presents two novel leptospiral membrane proteins: LipL1 and LipL2. In particular, these proteins are lipoproteins which are associated with pathogenic strains of Leptospira. LipL... Read More
Inventors: Haake, David A.; Shang, Ellen S.;, Assignee: The Regents of the University of California (Oakland, CA) |
Interleukin-1 beta converting enzyme like apoptotic protease-6
Toward these ends, and others, it is an object of the present invention to provide polypeptides, inter alia, that have been identified as novel ICE LAP-6 by homology between the amino acid sequence se... Read More
Inventors: Dixit, Vishva M.; He, Wei-Wu; Kikly, Kristine K.; Ruben, Steven M.;, Assignee: Human Genome Sciences, Inc. (Rockville, MD); SmithKline Beecham Corporation (Philadelphia, PA); University of Michigan (Ann Arbor, MI) |
Methods for treatment of tumors and metastases using a combination of anti-angiogenic and immuno therapies
What is claimed is: 1. A therapeutic composition comprising at least one angiogenesis inhibiting agent, which is an .alpha..sub.v.beta..sub.3 antagonist; and at least one anti-tumor immunotherapeutic ... Read More
Inventors: Lode, Holger N.; Reisfeld, Ralph A.; Cheresh, David A.; Gillies, Stephen D.;, Assignee: The Scripps Research Institute (La Jolia, CA) EMD Lexigen Research Center Corp. (Billerica, MA) |
Expressed sequence tags and encoded human proteins
The present invention relates to purified, isolated, or enriched 5' ESTs which include sequences derived from the authentic 5' ends of their corresponding mRNAs. The term "corresponding mRNA" refers t... Read More
Inventors: Edwards, Jean-Baptiste Dumas Milne; Duclert, Aymeric; Giordano, Jean-Yves;, Assignee: Genset S.A. (FR) |
C-type lectin transmembrane antigen expressed in human prostate cancer and uses thereof
The invention claimed is: 1. An isolated PC-LECTIN protein comprising the amino acid sequence of SEQ ID NO. 2. 2. The PC-LECTIN protein of claim 1 which is soluble. 3. The PC-LECTIN protein of claim... Read More
Inventors: Afar, Daniel E. H.; Hubert, Rene S.; Jakobovits, Aya; Raitano, Arthur B.;, Assignee: Agensys, Inc. (Santa Monica, CA) |
Antibodies for use in determining hemoglobin A.sub.1c
It is accordingly an object of the present invention to provide a comparatively simple, inexpensive, reliable test for determining the long-term blood sugar level of a patient based on the immunoassay... Read More
Inventors: Knowles, William J.; Marchesi, Vincent T.; Haigh, Wallace;, Assignee: Molecular Diagnostics, Inc. (West Haven, CT) |
Haptens, tracers, immunogens and antibodies for immunoassays for cotinine derivatives
OF THE INVENTION A hapten of the invention is substantially optically pure, and is particularly useful in an immunoassay for cotinine, a metabolite of nicotine. As used herein, the phrase "substantia... Read More
Inventors: Walling, John A.; Hu, Hsiang-Yun; Hasz, Barbara E.;, Assignee: Abbott Laboratories (Abbott Park, IL) |
Immunogens and the use thereof for obtaining antibodies against HBA.sub.1C
What is claimed is: 1. Composition of matter consisting essentially of polyclonal antibodies which specifically bind to HbA.sub.1c and which have less than 5.0% cross reactivity with HbA.sub.0, wherei... Read More
Inventors: Klein, Christian; Hubner-Parajsz, Christa; Batz, Hans-Georg; Rollinger, Wolfgang; Essig, Ulrich; Kerscher, Lorenz;, Assignee: Boehringer Mannheim GmbH (Mannheim, DE) |
Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same
The present invention overcomes the above mentioned drawbacks and provides methods for treating drug abuse. Using therapeutic compositions, in particular hapten-carrier conjugates, the present inventi... Read More
Inventors: Swain, Philip A.; Schad, Victoria C.; Greenstein, Julia L.; Exley, Mark A.; Fox, Barbara S.; Powers, Stephen P.; Gefter, Malcolm L.;, Assignee: ImmuLogic Pharmaceutical Corporation (Waltham, MA) |
Antibody against a 3-aminophenylboronic-glycated protein complex and its use in an immunoassay
OF THE INVENTION The present invention is directed to methods for developing and utilizing antibodies with preferred specificity for phenylboronic acid complexes of glycosylated proteins, for example... Read More
Inventors: Newman, Karel Z.; Odegaard, Bruce; Ogbonna, Godwin Orji; Schmidt, Jane A.;, Assignee: Beckman Coulter, Inc. (Fullerton, CA) |
Application of phytosterols (and their isomers), folic acid, cyanocobalamin and pyridoxin in dietetic (alimentary) fibers
The invention claimed is: 1. An oral pharmaceutical formulation comprising phytosterols and isomers thereof, folic acid, cyanocobalamine, pyridoxine and dietetic alimentary fibers intended for the tre... Read More
Inventors: Bruno, Roberto Luis; Falci, Marcio;, Assignee: Laboratorios Biosintetica LTDA. (Taboao Da Serra, BR) |
Stimulation of chemotaxis by chemotactic peptides
Accordingly, it is an object of this invention to provide a synthetic material having chemotactic properties towards cells such as fibroblasts and endothelial cells. It is a further object of this inv... Read More
Inventors: Urry, Dan W.; Long, Marianna;, Assignee: UAB Research Foundation (Birmingham, AL) |
Biological material pre-fixation treatment
OF PREFERRED EMBODIMENTS In one aspect, the present invention relates to an improved bioprosthetic heart valve having an improved resistance to post-implantation mineralization. In this aspect, the i... Read More
Inventors: Jaffe, Norman; Hancock, Warren B.;, Assignee: Hancock Jaffe Laboratories (Irvine, CA) |
Diagnosis of Williams syndrome
OF THE INVENTION The present invention is directed to the determination that SVAS and Williams syndrome map to the elastin gene and that molecular variants of the elastin gene cause or are involved i... Read More
Inventors: Keating, Mark T.; Leppert, Mark F.; Morris, Colleen A.;, Assignee: The University of Utah Research Foundation (Salt Lake City, UT) |
Biological material pre-fixation treatment
OF PREFERRED EMBODIMENTS In one aspect, the present invention relates to an improved bioprosthetic heart valve having an improved resistance to post-implantation mineralization. In this aspect, the i... Read More
Inventors: Jaffe, Norman; Hancock, Warren D.;, Assignee: Hancock Jaffee Laboratories (Irvine, CA) |
Method for bonding or fusion of biological tissue and material
Biological materials are joined, repaired or fused by heating the material in proximity to a mechanical support. In the preferred embodiment, the mechanical support comprises a patch or bridge structu... Read More
Inventors: Sawyer, Philip N.; Wallace, Donald G.; Yamamoto, Ronald K.;, Assignee: Fusion Medical Technologies, Inc. (Mountain View, CA) |
Diagnosis and treatment of supravalvular aortic stenosis and Williams syndrome
OF THE INVENTION The present invention is directed to the determination that SVAS and Williams syndrome map to the elastin gene and that molecular variants of the elastin gene cause or are involved i... Read More
Inventors: Keating, Mark T.; Leppert, Mark F.; Morris, Colleen A.;, Assignee: University of Utah Research Foundation (Salt Lake City, UT) |
Biological material pre-fixation treatment
OF PREFERRED EMBODIMENTS In one aspect, the present invention relates to an improved bioprosthetic heart valve having an improved resistance to post-implantation mineralization. In this aspect, the i... Read More
Inventors: Jaffe, Norman; Hancock, Warren D.;, Assignee: Hancock Jaffe Laboratories (Irvine, CA) |
Matrix substrate for a viable body tissue-derived prosthesis and method for making the same
OF THE INVENTION The present invention covers a process that thoroughly removes intact cells from body tissues such as vascular structures including the porcine heart valve and root structure. The pr... Read More
Inventors: Bishopric, Nanette H.; Dousman, Linda; Yao, Yung-mae M.;, Assignee: St. Jude Medical, Inc. (St. Paul, MN) |
Barrier webs having bioactive surfaces
What is claimed is: 1. A bioactive substrate comprising: a support; and a bioactive surface thereon, wherein the bioactive surface comprises: a shear-thinable, thixotropic polymer composition comprisi... Read More
Inventors: Caldwell, J. Michael;, Assignee: Nextec Applications, Inc. (Vista, CA) |
Biopolymer foams for use in tissue repair and reconstruction
OF THE INVENTION The present invention features biopolymer foams, composite biopolymer foams, biocompatible constructs comprising biopolymer foams and extracellular matrix particulates and methods fo... Read More
Inventors: Bell, Eugene; Sioussat, Tracy M.; Fofonoff, Timothy W.;, Assignee: Tissue Engineering, Inc. (Boston, MA) |
Periodate oxidative method for attachment of biomolecules to medical device surfaces
OF THE INVENTION As used in the specification and claims hereof, the following terms have the particular meanings and definitions set forth below. I define the term "biomolecule" appearing herein as ... Read More
Inventors: Keogh, James R.;, Assignee: Medtronic, Inc. (Minneapolis, MN) |
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