|
| Latest patents |
Results: 361-390 of 3116
|
Derivatives of choline binding proteins for vaccines
OF THE INVENTION In accordance with an aspect of the present invention there is provided a vaccine to produce a protective response against S. pneumoniae infections which employs a polypeptide which ... Read More
Inventors: Wizemann, Theresa M.; Koenig, Scott; Johnson, Leslie S.;, Assignee: MedImmune, Inc. (Gaithersburg, MD) |
Recombinant parainfluenza virus expression system and vaccines
What is claimed is: 1. An immunogenic formulation comprising a chimeric parainfluenza virus comprising (i) nucleotide sequences of Kansas-strain bovine parainfluenza virus type 3 genome comprising nuc... Read More
Inventors: Haller, Aurelia; Coelingh, Kathleen L.;, Assignee: MedImmune Vaccines, Inc. (Mountain View, CA) |
Recombinant influenza A viruses
OF THE INVENTION In one embodiment, the invention relates to genetically engineered NS gene constructs of an influenza A virus comprising sequence modifications, i.e. deletions or insertions, between... Read More
Inventors: Ferko, Boris; Egorov, Andre; Voglauer, Regina;, Assignee: Polymun Scientific Immunbiologische Forschung GmbH (Vienna, AT) |
Recombinant vector containing a sequence of a lipoprotein gene for the expression of nucleotide sequences
We claim: 1. A recombinant vector for the cloning, expression, and exposure at the surface of the external membrane of Gram-negative bacteria of a heterologous polypeptide, said vector comprising a nu... Read More
Inventors: Hamers, Raymond; Cornelis, Pierre;, Assignee: |
Immunogenic hybrid protein OprF-Oprl derived from Pseudomonas aeruginosa membrane proteins
Surprisingly, it was found by the inventors that a hybrid protein, wherein OprI is linked with its N-terminal end to a C-terminal portion of OprF is significantly more immunogenic than fusion proteins... Read More
Inventors: Knapp, Bernhard; Hungerer, Klaus-Dieter; Broker, Michael; von Specht, Bernd-Ulrich; Domdey, Horst;, Assignee: Chiron Behring GmbH & Co. (Marburg, DE) |
LktA deletion mutant of P. haemolytica
It is an object of the present invention to provide a P. haemolytica bacterium useful as a vaccine strain. It is another object of the present invention to provide a method of inducing immunity to pne... Read More
Inventors: Briggs, Robert E.; Tatum, Fred M.;, Assignee: Biotechnology Research and Development Corporation (Peoria, IL) |
Malaria vaccine
OF THE INVENTION It has been established that a mixture of the following novel peptide compounds represents a preferred embodiment of the present invention, namely, Tyr-Gly-Gly-Pro-Ala-Asn-Lys-Lys-As... Read More
Inventors: Patarroyo, Manuel E.;, Assignee: |
Protein copolymer malaria vaccine
OF THE INVENTION It has been established that a mixture of the following novel peptide compounds represents a preferred embodiment of the present invention, namely, Formula (I) Tyr-Gly-Gly-Pro-Ala-As... Read More
Inventors: Patarroyo, Manuel E.;, Assignee: |
Vaccine against the sporozoite stage of malaria
OF THE INVENTION The P.vivax CS gene is set forth below (together with the amino acid sequence for which its codes) ##STR1## The DNA fragment chosen for insertion in the yeast host was; ##STR2## This... Read More
Inventors: Nussenzweig, Victor; Barr, Philip;, Assignee: New York University (New York, NY); Chiron Corporation (Emeryville, CA) |
Malaria antigen
We claim: 1. A substantially pure polypeptide comprising the amino acid sequence of a glutamate-rich polypeptide (GLURP) derived from a Plasmodium falciparum antigen ("native GLURP"), said GLURP havin... Read More
Inventors: Dziegiel, Morten; Borre, Martin; Jepsen, Soren; Vuust, Jens; Rieneck, Klaus; Wind, Annette; Jakobsen, Palle H.;, Assignee: Statens Seruminstitut (Copenhagen, DK) |
Oligopeptide lyophilisate, their preparation and use
OF PREFERRED EMBODIMENTS The following Examples illustrate the invention. EXAMPLE 1 Approx. 1.5 liters of water for injection purposes are prepared in a suitable glass vessel. 210 g water for injecti... Read More
Inventors: Engel, Jurgen; Wichert, Burkhard; Sauerbier, Dieter; Reissmann, Thomas;, Assignee: Zentaris GmbH (Frankfurt, DE) |
Antithrombin nucleotides and proteins from horn fly
Isolated proteins with antithrombin activity and nucleotide sequences encoding the proteins are provided. The protein named thrombostasin is isolated from the salivary glands of Haematobia irritans, t... Read More
Inventors: Cupp, Eddie Wayne; Cupp, Mary Smith;, Assignee: Auburn University (Auburn, AL) |
Immunogenic conjugates comprising leukotoxin peptide fragments
OF THE INVENTION Substances having molecular weights less than 1000 daltons are not ordinarily antigenic. However, antibodies can be raised to small molecules by immunization with conjugates consisti... Read More
Inventors: Prickett, Kathryn S.;, Assignee: Immunex Corporation (Seattle, WA) |
Interleukin-2-leukotoxin gene fusions and uses thereof
The practice of the present invention will employ, unless otherwise indicated, conventional techniques of molecular biology, microbiology, virology, recombinant DNA technology, and immunology, which ... Read More
Inventors: Potter, Andrew; Campos, Manuel; Hughes, Huw P. A.;, Assignee: Veterinary Infectious Disease Organization (Saskatoon, CA); Ciba-Geigy Canada Ltd (Mississauga, CA) |
Chimeric protein comprising an RTX-family cytotoxin and interferon-2 or interferon
The practice of the present invention will employ, unless otherwise indicated, conventional techniques of molecular biology, microbiology, virology, recombinant DNA technology, and immunology, which ... Read More
Inventors: Potter, Andrew; Campos, Manuel; Hughes, Huw P. A.;, Assignee: University of Saskatchewan (Saskatchewan, CA); Ciba-Geigy Canada Ltd. (Mississauga, CA) |
GnRH-leukotoxin chimeras
The practice of the present invention will employ, unless otherwise indicated, conventional techniques of molecular biology, microbiology, virology, recombinant DNA technology, and immunology, which ... Read More
Inventors: Potter, Andrew A.; Manns, John G.;, Assignee: University of Saskatchewan (Saskatoon, CA) |
GNRH-leukotoxin chimeras
The practice of the present invention will employ, unless otherwise indicated, conventional techniques of molecular biology, microbiology, virology, recombinant DNA technology, and immunology, which ... Read More
Inventors: Potter, Andrew A.; Manns, John G.;, Assignee: University of Saskatchewan (Saskatoon, CA) |
Polynucleotides encoding LKT 111
The practice of the present invention will employ, unless otherwise indicated, conventional techniques of molecular biology, microbiology, virology, recombinant DNA technology, and immunology, which ... Read More
Inventors: Potter, Andrew A.; Manns, John G.;, Assignee: University of Saskatchewan (Saskatoon, CA) |
Methods and compositions for the treatment of defects in lipoprotein metabolism
In one aspect, the invention provides a recombinant viral vector comprising the DNA of, or corresponding to, at least a portion of the genome of an adenovirus, which portion is capable of infecting a ... Read More
Inventors: Wilson, James M.; Kozarsky, Karen; Strauss, III, Jerome;, Assignee: The Trustees of the University of Pennsylvania (Philadelphia, PA) |
Antisera against a PEB1 antigen from Campylobacter jejuni
It is an object of the present invention to provide highly specific and highly sensitive diagnostic tests for the presence of C. jejuni or C. coli infections. It is another object of the invention to ... Read More
Inventors: Blaser, Martin J.; Ellison, III, Richard T.; Pei, Zhi H.;, Assignee: Enteric Research Laboratories Inc. (Nashville, TN) |
Gene encoding invasion protein of campylobacter species
OF PREFERRED EMBODIMENTS The following standard abbreviations for the amino acid residues are used throughout the specification: A, Ala--alanine; C, Cys--cysteine; D, Asp--aspartic acid; E, Glu--glut... Read More
Inventors: Chan, Voon Loong; Joe, Angela; Hong, Yuwen;, Assignee: |
Preservatives for vaccines
New combinations of preservatives that pass antimicrobial testing requirements for United States Pharmacopeia (USP), British Pharmacopeia (BP), and European Pharmacopeia (EP). They are: (1) 1.5% benzy... Read More
Inventors: Ng, Assunta S.; Mancinelli, Ralph J.; Hennessey, John P.;, Assignee: Merck & Co., Inc. (Rahway, NJ) |
Methods and reagents for HLA class I A locus DNA typing
OF THE INVENTION To aid in understanding the invention, several terms are defined below. The terms "HLA-A gene" and "HLA-A locus" refer to a transcribed region of DNA that contains the coding sequenc... Read More
Inventors: Apple, Raymond J.; Bugawan, Teodorica L.; Erlich, Henry A.;, Assignee: Hoffmann-La Roche Inc. (Nutley, NJ) |
Immunomodulating compounds comprising d-isomers of amino acids
What is claimed is: 1. A peptide compound having immunomodulating activity comprising the sequence: RENLRIALRY (SEQ ID NO:12), wherein all of the amino acids are the D isomer and said immunomodulating... Read More
Inventors: Clayberger, Carol A.; Krensky, Alan M.;, Assignee: Stanford University (Board of Trustees of the Leland Standford Junior (Palo Alto, CA) |
Targeted destruction of pests
The present invention is drawn to a safe, cost-effective, environmentally-friendly and ecologically-sound bioengineered product for managing pests such as imported fire ants, and a method of making th... Read More
Inventors: Kline, Kimberly; Sanders, Bob G.;, Assignee: Research Development Foundation (Carson City, NV) |
Compositions and methods for the diagnosis and treatment of herpes simplex virus infection
OF THE INVENTION U.S. patents, U.S. patent application publications, U.S. patent applications, foreign patents, foreign patent applications and non-patent publications referred to in this specificati... Read More
Inventors: Day, Craig H.; Hosken, Nancy A.; Parsons, Joseph M.;, Assignee: Corixa Corporation (Seattle, WA) |
Intercellular adhesion molecule--2 and its binding ligands
What is claimed is: 1. A method for treating inflammation in a mammalian subject which comprises providing to a subject in need of such treatment an amount of anti-inflammatory agent sufficient to sup... Read More
Inventors: Springer, Timothy A.; Staunton, Donald E.; Dustin, Michael L.;, Assignee: Dana Farber Cancer Institute (Boston, MA) |
E2 subunit vaccine comprising recombinant pestivirus E2 protein
1. An E2 subunit vaccine comprising recombinant Classical Swine Fever Virus (CSFV) E2 glycoprotein produced in a baculovirus system, wherein said E2 glycoprotein is not immunoaffinity purified and con... Read More
Inventors: Kretzdorn, Dietmar; van de Wiel, Dirk Franciscus Marinus; de Smit, Abraham Johannes; Moormann, Robertus Jacobus Maria; Hamann, Erik Kees;, Assignee: Stichting Instituut voor Dierhouderij en Diergezondheid (Lelystad, NL); Bayer AG (Leverkussen, NL) |
Fibronectin binding protein-encoding DNA
We claim: 1. Plasmid pSDF102 as contained in the E. coli TG1 strain, having the deposit number DSM 4614. 2. Plasmid pSDF203 as contained in the E. cOli TG1 strain, having the deposit number DSM 4613. ... Read More
Inventors: Hook, Magnus; Lindberg, Kjell M.; Lindgren, Per-Eric; Signas, Lars C.;, Assignee: Alfa-Laval Agri International Aktiebolag (Tumba, SE) |
Fibronectin binding protein as well as its preparation
We claim: 1. A vaccine composition comprising an effective amount of a protein encoded by a hybrid DNA molecule comprising a nucleotide sequence from Staphylococcus aureus encoding an isolated protein... Read More
Inventors: Hook, Magnus; Lindberg, Martin K.; Signas, Lars C.; Wadstrom, Torkel M.; Froman, Gunnar;, Assignee: Alfa Laval AB (Tumba, SE) |
|
Drugs 
