Epoxy pipelining composition and method of manufacture
What is claimed is: 1. A cross-linked network polymeric coating on the interior surface of a pipe for carrying potable water, said polymeric coating being produced by in-situ cross-linking polymerizat... Read More
Inventors: Brady, Jr., Robert F.; Adkins, James D.;, Assignee: |
Fibronectin binding protein as well as its preparation
We claim: 1. A protein having fibronectin binding activity, wherein said protein is encoded by a hybrid DNA molecule from Staphylococcus aureus wherein the hybrid DNA molecule consists of the followin... Read More
Inventors: Hook, Magnus; Jonsson, Klas; Lindberg, Kjell Martin; Signas, Christer;, Assignee: Alfa-Laval Agri International Aktiebolag (Tumba, SE) |
Bacterial cell surface protein with fibronectin, fibrinogen, collagen and laminin binding ability, process for the manufacture of the protein and prophylactic treatment
We claim: 1. A vaccine composition comprising an isolated fibronectin binding protein derived from Staphylococcus aureus in an amount effective to provide protection from disease caused by Staphylococ... Read More
Inventors: Hook, Magnus; Lindberg, Kjell Martin; Wadstrom, Torkel Mikael;, Assignee: Alfa Laval AB (Tumba, SE) |
Fibronectin binding protein
We claim: 1. A pharmaceutical composition for the treatment of infections caused by S. dysgalactiae which comprises at least one protein or polypeptide derived from S. dysgalactiae having fibronectin ... Read More
Inventors: Hook, Magnus; Lindberg, Kjell Martin; Lindgren, Per-Eric; Signas, Lars Christer;, Assignee: Alfa Laval Agri International (SE) |
Methods for producing self-replicating infectious RSV particles comprising recombinant RSV genomes or antigenomes and the N, P, L, and M2 proteins
The present invention provides an isolated infectious RSV particle which comprises a recombinant RSV genome or antigenome, a nucleocapsid (N) protein, a nucleocapsid phosphoprotein (P), a large (L) po... Read More
Inventors: Collins, Peter L.;, Assignee: The United States of America as represented by the Department of Health and (Washington, DC) |
Antigen-specific human glycosylation inhibiting factor
OF THE INVENTION The present invention relates to substantially pure human antigen-specific GIF with specificity for an antigen associated with an undesirable immune response. This human antigen-spec... Read More
Inventors: Ishizaka, Kimishige;, Assignee: La Jolla Institute for Allergy and Immunology (La Jolla, CA) |
Slow-release, self-absorbing, drug delivery system
OF THE INVENTION I. Definitions To aid in the understanding of the specification and claims, including the scope to be given such terms, the following definitions are provided. Active Agent. By the t... Read More
Inventors: Guillen, Manuel;, Assignee: |
Mycobacterium vaccae for down-regulation of the Th2 activity of the immune system
What is claimed is: 1. A method of treating a disorder characterised by an up-regulation of Th2 activity of the immune system of an individual comprising; determining the amount of Th2 activity in the... Read More
Inventors: Rook, Graham A.; Stanford, John L.; Zumla, Alimuddin L.;, Assignee: Stanford Rook Limited (London, GB) |
Gestational agents for controlling cell proliferation
OF THE INVENTION The present invention provides for gestational agents that may be used to control cell proliferation. It is based, at least in part, on the theory that pregnancy operates, figurative... Read More
Inventors: Barnea, Eytan R.;, Assignee: |
Combined cancer treatment methods using therapeutic conjugates that bind to aminophospholipids
The present invention addresses the needs of the prior art by providing new compositions and methods for tumor vasculature imaging and destruction. The invention is based, in part, on the finding that... Read More
Inventors: Thorpe, Philip E.; Ran, Sophia; Brekken, Rolf A.;, Assignee: Board of Regents, The University of Texas System (Austin, TX) |
Treatment of equine protozoan myeloencephalitis using triazinediones
OF THE PREFERRED EMBODIMENTS The instant invention involves, in a preferred embodiment, the administration of an oral composition, containing triazinedione, such as diclazuril. The oral composition o... Read More
Inventors: Russell, Meri Charmyne;, Assignee: Mortar & Pestle Veterinary Pharmacy, Inc. (Des Moines, ID) |
Method for treatment of equine protozoal myeloencephalitis with thiazolides
OF THE INVENTION The method for treatment or prevention of equine protozoal myeloencephalitis according to the present invention comprises administration of a pharmaceutical composition comprising, a... Read More
Inventors: Rossignol, Jean-Fran.cedilla.ois; Ayers, Marc S.;, Assignee: Romark Laboratories, L.C. (Tampa, FL) |
Antigen test to detect equine protozoal myeloencephalitis in horse serum and cerebrospinal fluid
We claim: 1. In a method for detecting the presence of Sarcocystis neurona in an equine in an immunoassay, the improvement which comprises reacting a biological sample from the equine suspected of har... Read More
Inventors: Mansfield, Linda S.; Rossano, Mary G.; Murphy, Alice J.; Vrable, Ruth A.;, Assignee: Board of Trustees of Michigan State University (East Lansing, MI) |
Chimeric viral receptor polypeptides
OF THE PREFERRED EMBODIMENTS A long felt need in the field of diagnostic/therapeutic methods has been target cell specific delivery of diagnostic/therapeutic agents. Diagnostic/therapeutic agents can... Read More
Inventors: Meruelo, Daniel; Yoshimoto, Takayuki;, Assignee: New York University (New York, NY) |
Zinc ring protein
What is claimed is: 1. A substantially purified human zinc RING protein comprising the amino acid sequence of SEQ ID NO:1. 2. A pharmaceutical composition comprising a substantially purified human zin... Read More
Inventors: Hillman, Jennifer L.; Lal, Preeti; Shah, Purvi;, Assignee: Incyte Pharmaceuticals, Inc. (Palo Alto, CA) |
Glycosylated modified primate lentivirus envelope polypeptides
OF THE INVENTION It is important to elicit humoral immune responses directed toward conserved, functional elements of the HIV-1 exterior envelope glycoprotein, gp 120. Two functions common to virtual... Read More
Inventors: Wyatt, Richard T.; Sodroski, Joseph G.; Kwong, Peter D.; Hendrickson, Wayne A.;, Assignee: Dana-Farber Cancer Institute, Inc. (Boston, MA); The Trustees of Columbia University in the City of New York (New York, NY) |
Method for treating essential tremor with botulinum toxin type B
The Botulinumtoxins used according to the present invention are Botulinumtoxins type A, B, C, D, E, F and G. The physiologic groups of Clostridium botulinum types are listed in Table I.
... Read More
Inventors: Aoki, K. Roger; Grayston, Michael W.; Carlson, Steven R.; Leon, Judith M.;, Assignee: Allergan, Inc. (Irvine, CA) |
Method for identifying active anti apoptosis compounds
The invention claimed is: 1. A method for identifying test substances with antiapoptotic activity, comprising i) culturing cells selected from the group consisting of endothelial cells, smooth muscle ... Read More
Inventors: Freyberg, Mark A.; Friedl, Peter; Kaiser, Dirk;, Assignee: CytoTools GmbH (Darmstadt, DE) |
Adipocyte-specific protein homologs
Within one aspect the invention provides an isolated polypeptide comprising a sequence of amino acid residues that is at least 75% identical in amino acid sequence to residues 26-281 of SEQ ID NO:2, w... Read More
Inventors: Sheppard, Paul O.;, Assignee: ZymoGenetics, Inc. (Seattle, WA) |
Methods and compositions using molecular decoyants for ameliorating the undesired effects of foreign agents which bind to endogenous receptors
It is an object of the present invention to obviate the drawbacks of the prior art. It is a further object of the present invention to provide a novel approach for the prevention of formation of ligan... Read More
Inventors: Gershoni, Jonathan M.;, Assignee: |
Antibodies directed against binding-associated epitopes
I claim: 1. The monoclonal antibody secreted by the hybridoma cell line CG-10. 2. A hybridoma cell line CG-10, deposited with the European Collection of Animal Cell Culture (ECACC) under the accession... Read More
Inventors: Gershoni, Jonathan M.;, Assignee: Ramot University Authority for Applied Research and Industrial (IL) |
Antibodies directed against binding-associated epitopes
What is claimed is: 1. An antigenic epitope which is a member of a group consisting of: (i) an epitope consisting of a sequence in a member of a binding couple, which becomes substantially more access... Read More
Inventors: Gershoni, Jonathan M.;, Assignee: Ramot University Authority for Applied Research and Industrial (IL) |
Antibodies directed against binding associated epitopes
What is claimed is: 1. A method for immunizing an animal against a viral infection comprising administering to a subject an effective amount of an epitope or an anti-idiotype antibody of said epitope,... Read More
Inventors: Gershoni, Jonathan M.;, Assignee: Ramot University Authority for Applied Research and Industrial Development (IL) |
Chimeric human papillomavirus (HPV) L1 molecules and uses therefor
The present invention provides a novel method for the induction of high titered neutralizing antibody responses or therapeutic cellular responses against two or more HPV types with a single chimeric L... Read More
Inventors: Wilson, Susan D.; White, Wendy; Suzich, JoAnn; Mullikin, Brian;, Assignee: MedImmune, Inc. (Gaithersburg, MD) |
Membrane translocating peptide drug delivery system
The present invention fulfills this need by providing a membrane translocating peptide comprising a full-length peptide, derivative, fragment, motif, analog or peptidomimetic thereof (hereinafter, "MT... Read More
Inventors: O'Mahony, Daniel J.; Lambkin, Imelda J.;, Assignee: Elan Corporation, PLC (Dublin, IE) |
Choline binding proteins for anti-pneumococcal vaccines
In accordance with the present invention, bacterial surface antigens are provided which are suitable for use in immunizing animals against bacterial infection. More particularly, novel choline binding... Read More
Inventors: Masure, H. Robert; Rosenow, Carsten I.; Tuomanen, Elaine; Wizemann, Theresa M.;, Assignee: The Rockefeller University (New York, NY) |
Pneumococcal surface proteins and uses thereof
Knowledge of and familiarity with the applications incorporated herein by reference is assumed; and, those applications disclose the sequence of pspA as well as certain portions thereof, and PspA and... Read More
Inventors: Briles, David E.; McDaniel, Larry S.; Swiatlo, Edwin; Yother, Janet; Crain, Marilyn J.; Hollingshead, Susan; Tart, Rebecca; Brooks-Walter, Alexis;, Assignee: University of Alabama at Birmingham (Birmingham, AL) |
Stable radioiodine conjugates and methods for their synthesis
The present invention solves the problems of poor labeling efficiency and aggregate formation reported in the carbohydrate-based prior art in two general ways. In the first way, a new method is provi... Read More
Inventors: Govindan, Serengulam V.; Griffiths, Gary L.;, Assignee: Immunomedics, Inc. (Morris Plains, NJ) |
Method of immunizing humans against Salmonella typhi using a Vi-rEPA conjugate vaccine
OF THE INVENTION The invention provides methods of using conjugates of an S. typhi Vi polysaccharide which is covalently bound to the carrier rEPA with a dicarboxylic acid dihydrazide linker, prefera... Read More
Inventors: Kossaczka, Zuzana; Szu, Shousun Chen; Robbins, John B.;, Assignee: The United States of America as represented by the Department of Health and (Washington, DC) |
Pneumococcal polysaccharide conjugate vaccine
OF THE INVENTION A. The Novel Pn-Ps-PRO Conjugate and Polysaccharide Intermediates: The Pn-Ps-PRO conjugate product of this invention has a Pn-Ps to PRO ratio between 0.05 and 0.5 mg polysaccharide/m... Read More
Inventors: Marburg, Stephen; Tolman, Richard L.; Kniskern, Peter J.; Miller, William J.; Hagopian, Arpi; Ip, Charlotte C.; Hennessey, Jr., John P.; Kubek, Dennis J.; Burke, Pamela D.;, Assignee: Merck & Co., Inc. (Rahway, NJ) |
Drugs 
