Recombinant parainfluenza virus expression systems and vaccines
What is claimed is: 1. A chimeric recombinant parainfluenza virus comprising (i) nucleotide sequences of Kansas-strain bovine parainfluenza virus type 3 genome comprising nucleotides 1-5041 and nucleo... Read More
Inventors: Haller, Auriela; Coelingh, Kathleen L.;, Assignee: MedImmune Vaccines, Inc. (Mountain View, CA) |
T cell inhibitory receptor compositions and uses thereof
It has now been discovered that biliary glycoprotein (BGP; also known as CD66a and C-CAM), a member of the carcinoembryonic antigen family (CEA), is an inhibitory receptor for activated T cells contai... Read More
Inventors: Blumberg, Richard S.;, Assignee: The Brigham & Women's Hospital, Inc. (Boston, MA) |
Antibodies and Fv fragment recognizing antigen IOR C2
OF THE INVENTION cDNA Synthesis and Gene Amplification of the Variable Region of Murine C5. Cytoplasmic RNA was extracted from about 106 hybridoma cells of the monoclonal antibody C5 (Vázquez A.... Read More
Inventors: de Acosta Del Rio, Cristina Maria Mateo; Navarro, Lourdes Tatiana Roque; Morales, Alejo Morales; Rodrí, guez; Rolando Pé, rez; Á, vila; Marta Ayala (Ciudad de la Habana, CU), Cowley; Jorge Victor Gavilondo (Ciudad de la Habana, CU), Porto; Mar, Assignee: Centro Inmunologia Molecular (CU) |
Antigenically active amino acid sequences
I claim: 1. A synthetic peptide which displays the antigenicity of the VP1 protein of foot-and-mouth disease virus, Type O.sub.1, wherein said peptide is selected from amino acid sequences of the grou... Read More
Inventors: Geysen, Hendrik;, Assignee: Commonwealth Serum Laboratories Commission (Parkville, AU) |
Anti-angiogenic proteins and methods of use thereof
The present invention relates to proteins comprising the NC1 domain of an alpha chain of Type IV collagen having anti-angiogenic properties. In particular, the present invention relates to the novel p... Read More
Inventors: Kalluri, Raghuram;, Assignee: Beth Israel Deaconess Hospital Corp. (Boston, MA) |
Bovine rotavirus genes
OF THE INVENTION The genome of group A BRV, group B BRV and group C BRV comprise 11 discrete segments of linear double-stranded RNA, hereinafter referred to as "dsRNA". The dsRNA fragments are number... Read More
Inventors: Saif, Linda J.; Parwani, Anil; Chang, Kyeong-Ok; Kim, Wonyong; Gadfield, Kathy;, Assignee: The Ohio State University Research Foundation (Columbus, OH) |
Intein-mediated protein ligation of expressed proteins
In accordance with the present invention, there is provided a method for the ligation of expressed proteins utilizing one or more inteins which display cleavage at their N- and/or C-termini. In accord... Read More
Inventors: Evans, Thomas C.; Xu, Ming-Qun; Chong, Shaorong;, Assignee: New England Biolabs, Inc. (Beverly, MA) |
Polymer conjugates of biologically active agents and extension moieties for facilitating conjugation of biologically active agents to polymeric terminal groups
In one aspect of the invention, compounds of Formula (I) are provided: ##STR2## wherein: G is a linear or branched polymer residue; Y.sub.1 and Y.sub.2 are independently O, S, or NR.sub.9 ; M.sub.1 -M... Read More
Inventors: Greenwald, Richard B.; Choe, Yun H.;, Assignee: Enzon, Inc. (Piscataway, NJ) |
Proteins with increased levels of essential amino acids
OF THE INVENTION Choices of substitutions described herewithin are optionally grouped within parentheses and are separated by a semicolon. The native amino acid preceeds the position number using SEQ... Read More
Inventors: Rao, Aragula Gururaj; Roesler, Keith R.;, Assignee: Pioneer Hi-Bred International, Inc. (Des Moines, IA) |
Therapeutic somatostatin analogs
We claim: 1. An octapeptide of the formula D-.beta.-Nal-Cys-Tyr-D-Trp-Lys-Val-Cys-Thr-NH.sub.2, or a pharmaceutically acceptable salt thereof. 2. The octapeptide of claim 1 of the formula D-Phe-Cys-.b... Read More
Inventors: Coy, David H.; Murphy, William A.; Heiman, Mark L.;, Assignee: The Administrators of the Tulane Educational Fund (New Orleans, LA) |
Tumor growth-inhibiting somatostatin analogues, pharmaceutical compositions containing them and process for preparing same
What we claim is: 1. A heptapeptide or octapeptide amide derivative selected from the group consisting of ##STR14## 2. A pharmaceutical composition which comprises as active ingredient a heptapeptide ... Read More
Inventors: Keri, Gyorgy; Mezo, Imre; Horvath, Aniko; Vadasz, Zsolt; Teplan, Istvan; Balogh, Agnes; Csuka, Orsolya; Bokonyi, Gyongyi; Szoke, Balas; Horvath, Judit; Idei, Miklos; Seprodi, Janos;, Assignee: Biosignal Kutato-Fejlesztokft (Budapest, HU) |
Somatostatin analogue composition and use in treating breast cancer
What is claimed is: 1. A method of treating breast cancer in a subject which comprises administering a therapeutically effective amount of octreotide or octreotide as a pharmaceutically acceptable sal... Read More
Inventors: Cavanak, Thomas; Harris, Alan;, Assignee: Novartis AG (Basel, CH) |
Inactivating process for lipid envelopped virus, and new antivirus lipopeptides
What is claimed is: 1. A method of inactivating substantially all lipid-enveloped viruses in a composition comprising at least one isolated protein, which comprises contacting said composition with a ... Read More
Inventors: Vollenbroich, Dirk; Vater, Joachim; Pauli, Georg; Kamp, Roza Maria;, Assignee: |
Assays for agonists and antagonists of recombinant human calcium channels
OF THE INVENTION For the first time there is provided DNAs for making recombinant human calcium channels and in vitro methods for testing compounds for calcium channel agonist and antagonist activity... Read More
Inventors: Harpold, Michael M.; Ellis, Steven B.; Williams, Mark E.; Feldman, Daniel H.; McCue, Ann F.; Brenner, Robert;, Assignee: The Salk Institute Biotechnology/Industrial Assoc. Inc. (La Jolla, CA) |
Cells expressing calcium channel .alpha.2 subunit-encoding DNA, optionally with a reporter gene for screening assays
OF THE INVENTION In short, we have discovered a cDNA which codes for the (alpha).sub.1 -subunit of an animal calcium channel (see FIGS. 1a-1j and a cDNA which codes for the (alpha).sub.2 -subunit of ... Read More
Inventors: Ellis, Steven B.; Williams, Mark E.; Harpold, Michael M.; Schwartz, Arnold; Sartor, Jean; Brenner, Robert;, Assignee: Sibia Neurosciences, Inc. (La Jolla, CA) |
Calcium channel Alpha 2 subunit polypeptides
OF THE INVENTION In short, we have discovered a cDNA which codes for the (alpha).sub.1 -subunit of an animal calcium channel (see FIG. 1) and a cDNA which codes for the (alpha).sub.2 -subunit of an a... Read More
Inventors: Ellis, Steven Bradley; Williams, Mark E.; Harpold, Michael Miller; Sartor, Jean; Brenner, Robert;, Assignee: SIBIA Neurosciences, Inc. (La Jolla, CA) |
Process for preparing glycopeptide phosphonate derivatives
OF THE INVENTION This invention relates to novel processes for preparing glycopeptide phosphonate derivatives having an amino-containing side chain. When describing such processes, the following term... Read More
Inventors: Leadbetter, Michael R.; Linsell, Martin S.; Lee, Junning; Liu, Jyanwei;, Assignee: Theravance, Inc. (South San Francisco, CA) |
Method of prevention of pseudomonas infection
The invention includes, in one aspect, a method of preventing infection by Pseudomonas aeruginosa and immunologically related organisms in a subject. One method described by the invention is a passive... Read More
Inventors: Hodges, Robert S.; Irvin, Randall T.; Paranchych, William; Sokol, Pamela A.; Woods, Donald E.;, Assignee: S.P.I. Synthetic Peptides Incorporated (Edmonton, CA) |
Methods for treating cardiovascular diseases with botulinum toxin
I claim: 1. A method for treating a cardiovascular disease the method comprising the steps of: (a) administering an effective amount of a botulinum neurotoxin directly into a wall of a coronary artery... Read More
Inventors: Brooks, Gregory F.; Donovan, Stephen;, Assignee: Allergan, Inc. (Irvine, CA) |
Anti-fungal histatin-based peptides
OF THE INVENTION This invention relates to peptides which have anti-fungal activity, in which the amino acid sequences represent defined portions of the amino acid sequences of naturally occurring hu... Read More
Inventors: Oppenheim, Frank G.; Xu, Tao;, Assignee: The Trustees of Boston University (Boston, MA) |
Methods of treating fungal infections using histatin-based peptides
OF THE INVENTION This invention relates to peptides which have anti-fungal activity, in which the amino acid sequences represent defined portions of the amino acid sequences of naturally occurring hu... Read More
Inventors: Oppenheim, Frank G.; Xu, Tao;, Assignee: The Trustees of Boston University (Boston, MA) |
Short peptides which selectively modulate the activity of serine/threonine kinases
OF THE INVENTION A serine/threonine kinase (hereinafter "STK") is an intracellular or membrane bound protein which uses the gamma phosphate of ATP or GTP to generate phosphate monoesters on the hydro... Read More
Inventors: Ben-Sasson, Shmuel A.;, Assignee: Children's Medical Center Corporation (Boston, MA); Yissum Research Development Company of the Hebrew University of Jerusalem (Jerusalem, IL) |
Peptides derived from glutamic acid decarboxylase
OF THE INVENTION The present invention relates to the manipulation of genetic materials by recombinant DNA procedures which make possible the production of polypeptides possessing part or all of the ... Read More
Inventors: Tobin, Allan J.; Erlander, Mark G.; Kaufman, Daniel L.; Clare-Salzler, Michael J.;, Assignee: The Regents of the University of California (Oakland, CA) |
Gas pressure reducing regulator
I claim: 1. A gas pressure regulator for reducing high inlet gas pressure from a source to low outlet gas pressure comprising: a. a body having an inlet for communication with a high pressure gas sour... Read More
Inventors: Zwicker, Roger D.;, Assignee: Victor Equipment Company (Denton, TX) |
Recombinant dimeric envelope vaccine against flaviviral infection
What is claimed is: 1. A vaccine that generates a protective, neutralizing antibody response to a Flavivirus in a murine host, wherein said vaccine comprises a therapeutically effective amount of a di... Read More
Inventors: Peters, Iain D.; Coller, Beth-Ann G.; McDonell, Michael; Ivy, John M.; Harada, Kent;, Assignee: Hawaii Biotechnology Group, Inc. (Aiea, HI) |
Heteropolymeric triplexes containing watson-crick triplets
The invention provides triplex complexes comprising a single-stranded probe bound to a double-stranded nucleic acid target, wherein the probe comprises a heteropolymeric nucleic acid or a heteropolyme... Read More
Inventors: Erikson, Glen H.; Daksis, Jasmine I.; Picard, Pierre;, Assignee: Ingeneus Corporation (Bridgetown, BB) |
Methods for diagnosing and treating autoimmune disease
What is claimed is: 1. A method of restoring NF.kappa.B activity in a mammal afflicted with an automimmune disease resulting from a reduction in NF.kappa.B activity, comprising administering to a mamm... Read More
Inventors: Faustman, Denise L.; Hayashi, Takuma;, Assignee: General Hospital Corporation (Boston, MA) |
Cadherin-specific antibodies and hybridoma cell lines
The present invention is illustrated by the following examples wherein Example 1 describes the isolation of cDNA sequences encoding rat cadherins-4 through -11 and -13; Example 2 describes the isolat... Read More
Inventors: Suzuki, Shintaro;, Assignee: Doheny Eye Institute (Los Angeles, CA) |
Nucleic acids encoding protocadherin
The present invention is illustrated by the following examples wherein Examples 1, 2 and 3 describe the isolation by PCR of protocadherin polynucleotide sequences. Example 3 also describes the chromo... Read More
Inventors: Suzuki, Shintaro;, Assignee: Doheny Eye Institute (Los Angeles, CA) |
Therapeutic agent for rheumatic disease
In accordance with a first aspect of the present invention a new therapeutic agent for rheumatic disease is provided, which comprises an anti-Fas monoclonal antibody, an active ingredient, which react... Read More
Inventors: Nishioka, Kusuki; Yonehara, Shin;, Assignee: Santen Pharmaceutical Co., Ltd. (Osaka, JP) |
Drugs 
