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Results: 451-480 of 3116
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Methods and compositions for treatment of inflammatory disease using cadherin-11 modulating agents
The invention is based, in part, on the discovery of cadherin-11 mRNA and protein expression in cells, namely human type B synoviocytes, recovered from the synovium of patients with inflammatory joint... Read More
Inventors: Brenner, Michael B.; Valencia, Xavier;, Assignee: The Brigham and Women's Hospital, Inc. (Boston, MA) |
Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants
OF THE INVENTION The practice of the present invention will employ, unless otherwise indicated, conventional techniques of molecular biology, microbiology, recombinant DNA, and immunology, which are ... Read More
Inventors: Barchfeld, Gail; Del Giudice, Giuseppe; Rappuoli, Rino;, Assignee: Chiron Corporation (Emeryville, CA) |
Heat shock protein-based vaccines and immunotherapies
The present invention relates to methods and compositions for inducing an immune response in a subject, wherein at least one heat shock protein in combination with one or more defined target antigens ... Read More
Inventors: Rothman, James E.; Hartl, Franz-Ulrich; Hoe, Mee H.; Houghton, Alan; Takechi, Yoshizumi; Mayhew, Mark;, Assignee: Sloan-Kettering Institute for Cancer Research (New York, NY) |
Synergistic composition comprising a fibroblast growth factor and a sulfated polysaccharide, for use as antiviral agent
We claim: 1. A pharmaceutical composition, comprising an amount of: (i) a fibroblast growth factor selected from the group consisting of an amidated human or bovine fibroblast growth factor, a human o... Read More
Inventors: Ungheri, Domenico; Garofano, Luisa; Battistini, Carlo; Carminati, Paolo; Mazue, Guy;, Assignee: Farmitalia Carlo Erba S.R.L. (Milan, IT) |
Compositions and methods for treating cancer and hyperproliferative disorders
We claim: 1. A composition comprising, (a) a fibroblast growth factor or immunogenic peptide thereof; and (b) a liposome wherein the fibroblast growth factor or immunogenic peptide thereof is incorpor... Read More
Inventors: Nacy, Carol A.; Holaday, John W.;, Assignee: EntreMed, Inc. (Rockville, MD) |
Oral supplement composition containing a plurality of mushroom strains
The invention claimed is: 1. An oral supplement composition for use in enhancing the immune system of an animal or human, comprising: a. an orally ingestible carrier or diluent; and b. fourteen differ... Read More
Inventors: Keith, Alec D.; Gaisford, Kelly N.; Miller, Andrew H.;, Assignee: Gaisford and Miller, Inc. (Burlingame, CA) |
Recombinant herpesvirus of turkeys and use thereof
What is claimed is: 1. A recombinant herpesvirus of turkeys harboring an F protein gene of Newcastle disease virus under the control of a promoter of which sequence is shown in SEQ No.1; wherein said ... Read More
Inventors: Saitoh, Shuji; Okuda, Takashi; Kubomura, Mayumi; Dorsey, Kristi M.;, Assignee: Zeon Corporation (Tokyo, JP) |
Method of plasmid recovery and apparatus for doing so
OF THE INVENTION In FIG. 1 is shown a first embodiment of a process according to the present invention. The first step 10 is to disrupt the cells in question so as to free the plasmid or other DNA ma... Read More
Inventors: Leonard, Jack Thacher;, Assignee: Millipore Corporation (Billerica, MA) |
Antimicrobial and anti-inflammatory peptides for use in human immunodeficiency virus
The present invention is directed to a method and pharmaceuticals for treating HIV and secondary infection. One aspect of this invention involves the use of one or more polypeptides with an amino acid... Read More
Inventors: Catania, Anna P.; Lipton, James M.;, Assignee: Zengen, Inc. (Woodland Hills, CA) |
Carrier protein having an adjuvant effect, immunogenic complex containing it, process for their preparation, nucleotide sequence and vaccine
What is claimed is: 1. An isolated adjuvant comprising at least a fragment of the P40 protein of Klebsiella pneumoniae, said fragment having the amino acid sequence of SEQ ID NO: 8. 2. The adjuvant of... Read More
Inventors: Binz, Hans; Baussant, Thierry; Haeuw, Jean-Fran.cedilla.ois; Nguyen Ngoc, Thien;, Assignee: Pierre Fabre Medicament (Boulogne, FR) |
Methods for treating diseases caused by deficiencies of recombinant alpha-L-iduronidase
OF THE INVENTION In one aspect, the present invention features a method to produce .alpha.-L-iduronidase in amounts which enable using the enzyme therapeutically. In general, the method features tran... Read More
Inventors: Kakkis, Emil D.;, Assignee: |
Streptococcal C5a peptidase vaccine
The present invention provides a vaccine, and methods of vaccination, effective to prevent or reduce the incidence of .beta.-hemolytic Streptococcus in susceptible mammals, including humans, and domes... Read More
Inventors: Cleary, Paul Patrick;, Assignee: Regents of the University of Minnesota (Minneapolis, MN) |
Peptides for activation and inhibition of .delta.PKC
Accordingly, it is an object of the invention to provide a method of protecting tissue from damage due to an ischemic event. It is a further object of the invention to provide a method of administerin... Read More
Inventors: Mochly-Rosen, Daria; Chen, Leon E.;, Assignee: The Board of Trustees of the Leland Stanford Junior University (Stanford, CA) |
Composition and method for the treatment of sinusitis
Accordingly, it is the general object of the present invention to provide a composition and method for treatment of chronic sinusitis. More particularly, it is a further object of the present inventio... Read More
Inventors: Nicolay, Phil Arnold;, Assignee: |
Membrane receptor reagent and assay
Here, a novel type of membrane-receptor reagent, suitable for high performance membrane receptor microarrays, is taught. As will be discussed in later sections, this type of microarray may have high u... Read More
Inventors: Zweig, Stephen Eliot;, Assignee: |
Composition comprising low molecular weight hyaluronic acid fragments
What is claimed is: 1. A composition comprising dendritic cells prepared by: (a) isolating mononuclear cells from blood (b) culturing said mononuclear cells, together with hyaluronic acid fragments, i... Read More
Inventors: Simon, Jan; Martin, Stefan; Termeer, Christian;, Assignee: Universitaetsklinikum Freiburg (Freiburg, DE) |
Composition and method for immunomodulation in mammals
Substantially or completely immunoglobulin free material fractionated from mammalian serum, preferably goat serum, helps retard pathogenesis in mammals, supporting the belief that the substantially i... Read More
Inventors: Ansley, Daniel R.;, Assignee: |
Prostatic acid phosphatase immuno assay
We claim: 1. In an immunoassay for PAP wherein the amount of PAP in PAP standards is determined, the improvement comprising contacting the standards with a composition for stabilizing the enzymatic ac... Read More
Inventors: Josephson, Lee;, Assignee: Baxter Travenol Laboratories, Inc. (Deerfield, IL) |
Monoclonal antibody to prostate-derived acid phosphatase and method for determination of acid phosphatase using the same as well as kit for determination
The present inventors have made extensive investigations to solve the problems involved in the foregoing methods. As a result, it has been found that using PAP as an antigen, a novel monoclonal antibo... Read More
Inventors: Kuroiwa, Katsumasa; Katayama, Katsuhiro; Tomiyama, Takahiro; Miura, Toshihide; Nagasawa, Takeshi;, Assignee: Nitto Boseki Co., Ltd. (Fukushima, JP) |
Stable vaccine compositions for parenteral administration, a method for their use, and a process for their preparation
OF THE INVENTION In accordance with the present invention, the stable vaccine compositions comprise a macrolide compound as hereinafter defined, a water soluble organic solvent; a dispersing agent; a... Read More
Inventors: Cobb, Ramune Marija; Schwartzkoff, Christopher Leigh;, Assignee: American Cyanamid Company (Madison, NJ) |
HBV capsid-binding peptide immunogens
OF THE INVENTION In order that the invention herein described may be more fully understood, the following detailed description is set forth. According to one embodiment of this invention, mixtures of... Read More
Inventors: Murray, Kenneth;, Assignee: Biogen Idec MA Inc. (Cambridge, MA) |
Corticotropin-releasing factor2 receptors
Briefly stated, the present invention provides compositions and methods which utilize CRF.sub.2 receptors (also termed "CRF.sub.2 Corticotropin-Releasing Factor receptors" or "CRF.sub.2 R"). Within on... Read More
Inventors: Lovenberg, Timothy W.; Oltersdorf, Tilman; Liaw, Chen Wang; Grigoriadis, Dimitri E.; Chalmers, Derek T.; DeSouza, Errol B.;, Assignee: Neurocrine Biosciences Inc. (San Diego, CA) |
Molecules that home to various selected organs or tissues
The present invention provides molecules that selectively home to various normal organs or tissues, including to lung, skin, pancreas, retina, prostate, ovary, lymph node, adrenal gland, liver or gut.... Read More
Inventors: Ruoslahti, Erkki; Pasqualini, Renata;, Assignee: The Burnham Institute (San Diego, CA) |
Ileal symbiont intracellularis propagation in suspended host cells
We claim: 1. A method for cultivating Ileal symbiont intracellularis comprising: infecting cultured cells with an inoculum comprising Ileal symbiont intracellularis, incubating said infected cells at ... Read More
Inventors: Knittel, Jeffrey P.; Roof, Michael B.;, Assignee: NOBL Laboratories, Inc. (Ames, IA) |
Attenuated Bovine Respiratory Syncytial virus
OF THE INVENTION Thus, one embodiment of the invention provides Bovine Respiratory Syncytial Virus not capable to express a functional SH-protein and G-protein due to a mutation in the genes encoding... Read More
Inventors: Buchholz, Ursula J.; Schmidt, Ulrike;, Assignee: Akzo Nobel N.V. (Arnhem, NL) |
Reagent for detecting and monitoring viral infections
What is claimed is: 1. A reagent for diagnosing a viral infection, comprising (1) an immunodominant fragment of a protein of the virus comprising at most 60 amino acids; and (2) a mixture of convergen... Read More
Inventors: Tranchand-Bunel, Denis; Gras-Masse, Helene; Auriault, Claude; Tartar, Andre; Diesis, Eric; Bourez, Brigitte;, Assignee: Institut Pasteur de Lille (Lille, FR); Centre National de la Recherche Scientifique-CNRS (Paris, FR) |
Differential cytotoxicity of alternative forms of rotavirus nonstructural protein 4
OF THE INVENTION Rotavirus SA11 was first isolated by Malherbe et al. in 1963 (2). The passage history of SA11 in Dr. Malherbe's laboratory is not available. The passage history for the virus used fo... Read More
Inventors: Tian, Peng; Zamb, Timothy J.; Udem, Stephen A.;, Assignee: Wyeth Holdings Corporation (Madison, NJ) |
Synthesis of protein with an identification peptide, and hybrid polypeptide incorporating same
In accordance with the present invention, a hybrid molecule composed of a selected or constituent protein and an identification or marker peptide is produced by recombinant DNA techniques. The identif... Read More
Inventors: Hopp, Thomas P.; Bektesh, Susan L.; Conlon, III, Paul J.; March, Carl J.;, Assignee: Immunex Corporation (Seattle, WA) |
Extracellular segments of human e immunoglobulin anchoring peptides and antibodies specific therefor
OF THE PREFERRED EMBODIMENTS AND THEIR MANNER AND PROCESS OF MAKING AND USING 1. Migis Epitopes and Their Uses in Therapy and Diagnosis Membrane-bound immunoglobulins on B cells differ from the secre... Read More
Inventors: Chang, Tse W.;, Assignee: Tanox Biosystems, Inc. (Houston, TX) |
Recombinant birth control vaccine
We claim: 1. A nucleotide sequence (I) coding for a fused peptide, the sequence consisting of: (A) a beta subunit of a mammalian gonadotropin in reading frame alignment with and followed by (B) the tr... Read More
Inventors: Talwar, Gursaran Prasad; Srinivasan, Jay; Chakrabarti, Sekhar;, Assignee: |
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