Immunodiagnostic assay for rheumatoid arthritis
We claim: 1. A ligand comprising an antibody domain specific for an antigenic determinant of a complex of human IgA and .alpha..sub.1 -antitrypsin, said antibody domain being substantially non reactiv... Read More
Inventors: Stanworth, Dennis Raymond; Lewin, Ian Victor; Nayyar, Sarita;, Assignee: Peptide Therapeutics Limited (Cambridgeshire, GB2) |
Cross-linkers with high reactivity and solubility and their use in the preparation of conjugates for targeted delivery of small molecule drugs
1. A method of making a conjugate comprising a cell binding agent and one or more small molecule drugs, wherein said conjugate is represented by formula (V): ##STR19## wherein CB represents the cell b... Read More
Inventors: Widdison, Wayne Charles;, Assignee: Immunogen, Inc. (Cambridge, MA) |
Genes encoding hybrid bacillus thuringiensis toxins
What is claimed is: 1. An isolated DNA molecule encoding a polypeptide comprising an insecticidal Bacillus thuringiensis hybrid toxin fragment, comprising: a) at a C-terminus of said fragment, domain ... Read More
Inventors: Bosch, Hendrik Jan; Stiekema, Willem Johannes;, Assignee: Syngenta Participations AG (Schwaarzwaldallee, CH) |
Separation of alpha interferon receptor proteins and antibodies therefor
We have partially purified two distinct Type I interferon receptor proteins from lymphoblastoid cells, with apparent molecular weights of 95-105K and 50-63K respectively. These two proteins may have d... Read More
Inventors: Vellucci, Laura C.; Scott, Steven R.; Liao, Mei-June; Testa, Douglas;, Assignee: Interferon Sciences, Inc. (New Brunswick, NJ) |
Method and apparatus for preparing a poly(arylene ether)
OF THE PREFERRED EMBODIMENTS Having extensively studied the precipitation of poly(arylene ether) resins under laboratory-scale, pilot plant, and manufacturing conditions, the present inventors have o... Read More
Inventors: Peemans, Rudy Francois Alain Jos; Knol, Wiebe; Groefsema, Peter;, Assignee: General Electric Company (Pittsfield, MA) |
Factor Xa inhibitors
The present invention provides compounds that specifically inhibit factor Xa activity. A compound of the invention has the structure X.sub.1 -Y-I-R-X.sub.2, wherein X.sub.1 is a hydrogen (H), acyl, al... Read More
Inventors: Al-Obeidi, Fahad; Lebl, Michal; Ostrem, James A.; Safar, Pavel; Stierandova, Alena; Strop, Peter; Walser, Armin;, Assignee: Aventis Pharmaceuticals Inc. (Bridgewater, NJ) |
Protein tyrosine kinase agonist antibodies
The genes isolated as described herein are referred to, collectively, as "protein tyrosine kinase genes" or "pTK genes". The nucleic acid sequences of some of these genes, isolated as discussed herein... Read More
Inventors: Bennett, Brian D.; Goeddel, David; Matthews, William;, Assignee: Genentech, Inc. (South San Francisco, CA) |
Synthesis of high solids resins from amine terminated polyamides
OF A PREFERRED EMBODIMENT OF THE INVENTION The present invention contemplates a process for the synthesis of a polyaminoamide intermediate polymer, as well as the intermediate polymer itself, compris... Read More
Inventors: Maslanka, William W.;, Assignee: Hercules Corporation (Wilmington, DE) |
Neoglycoproteins
What is claimed is: 1. A polyamide conjugate comprising either (a) an oligosaccharide terminating with an alpha-linked D-galactopyranose or N-glycol-neuraminic acid at its reducing end; or (b) cellulo... Read More
Inventors: Duthaler, Rudolf; Katopodis, Andreas; Kinzy, Willy; Ohrlein, Reinhold; Thoma, Gebhard;, Assignee: Novartis AG (Basel, CH) |
Pneumococcal vaccines formulated with interleukin-12
OF THE INVENTION Work described herein reveals the ability of IL-12 to increase the immune response to alum-based pneumococcal vaccines, particularly serotype 14 and serotype 6B pneumococcal glycocon... Read More
Inventors: LaPosta, Vincent J.; Eldridge, John H.;, Assignee: Wyeth Holdings Corporation (Madison, NJ) |
Mammalian two-hybrid system for screening for modulators of the accumulation of metabolic products
This invention provides novel approaches to the treatment (e.g. amelioration of one or more symptoms) of pathological states characterized by the undesired accumulation of one or more metabolic produc... Read More
Inventors: Tetsu, Osamu; Wakita, Kenichi; McCormick, Frank;, Assignee: The Regents of the University of California (Oakland, CA) |
Peptides for inducing cytotoxic T lymphocyte responses to hepatitis B virus
The present invention provides peptides which induce MHC class I restricted cytotoxic T lymphocyte responses against HBV antigen. The peptides of interest are derived from the HBV envelope. In certain... Read More
Inventors: Chisari, Francis V.;, Assignee: The Scripps Research Institute (La Jolla, CA) |
Method for the treatment of bacterial vaginal infections
OF THE INVENTION The method for treating bacterial infections comprises treating the infection with a therapeutic agent comprising an effective amount of at least one lyric enzyme produced by a bacte... Read More
Inventors: Fischetti, Vincent; Loomis, Lawrence;, Assignee: New Horizons Diagnostics Corporation (Columbia, MD); Rockefeller University (NY, NY) |
Ubiquitin ligases as therapeutic targets
OF THE INVENTION The present invention relates to novel F-box proteins and to novel substrates of F-box proteins. The present invention relates to screening assays designed to identify substrates of ... Read More
Inventors: Chiaur, Dah Shiarn; Pagano, Michele; Latres, Esther;, Assignee: New York University (New York, NY) |
Methods for treating tension headache
The Botulinum toxins used according to the present invention are Botulinum toxins type A, B, C, D, E, F and G. The physiologic groups of Clostridium botulinum types are listed in Table I.
... Read More
Inventors: Aoki, K. Roger; Grayston, Michael W.; Carlson, Steven R.; Leon, Judith M.;, Assignee: Allergan, Inc. (Irvine, CA) |
Gene and process for producing a thermostable urease
The present invention relates to a novel isolated structure gene of urease, to a recombinant DNA capable of replicating in Escherichia coli carrying a vector into which said structural gene has been i... Read More
Inventors: Uozumi, Takeshi; Masaki, Haruhiko; Hidaka, Makoto; Nakamura, Akira; Maeda, Michihisa; Yoneta, Yasuo;, Assignee: Sapporo Breweries Limited (Tokyo, JP) |
Polynucleotides encoding mammaglobin, a mammary-specific breast cancer protein
Briefly, therefore, the present invention is directed to the identification of novel genes whose expression is increased in breast cancer and to the isolating of cDNA's from the mRNA's of these genes.... Read More
Inventors: Watson, Mark A.; Fleming, Timothy P.;, Assignee: Washington University (St. Louis, MO) |
Enzyme-catalyzed polyamides and compositions and processes of preparing and using the same
OF THE INVENTION The present invention is directed to enzyme-catalyzed polyamides, and processes for producing polyamides by reacting at least one diester and at least one polyamine in the presence o... Read More
Inventors: Cheng, Huai N.; Gu, Qu-Ming; Maslanka, William W.;, Assignee: Hercules Incorporated (Wilmington, DE) |
Anti-cryptosporidium parvum preparations
OF THE PREFERRED EMBODIMENT As disclosed herein, the 3E2 monoclonal antibody (mAb) has binding-specificity for a C parvum surface and apical glycoprotein complex of sporozoites and merozoites, and ef... Read More
Inventors: Riggs, Michael W.; Perryman, Lance E.;, Assignee: North Carolina State University (Raleigh, NC) |
Method of improving the primary energy metabolism of mammalian cell lines
What is claimed is: 1. A method of improving the primary energy metabolism of a mammalian cell, comprising i) transforming or transfecting said cell with an expression vector comprising a structural g... Read More
Inventors: Wagner, Roland; Irani, Noushin; Wirth, Manfred; Van Der Heuvel, Joop;, Assignee: Gesellschaft fuer Biotechnologiesche Forschung mbH (GBF) (Braunschweig, DE) |
Isolation, structural elucidation and synthesis of novel antineoplastic substances denominated "combretastatins
Accordingly, what is claimed is: 1. The method of treating a mammalian host afflicted with lymphocytic leukemia comprising administering to said host a pharmaceutical preparation containing as its ess... Read More
Inventors: Pettit, George R.; Singh, Sheo B.;, Assignee: Arizona Board of Regents acting on behalf of Arizona State University (Tempe, AZ) |
Contoured ventilation system for metal roofs
The invention is generally directed to a building structure adapted to allow for ventilation of vapors from within the structure so as to retard deterioration of the structure. A sloped roof has a dec... Read More
Inventors: Rotter, Martin J.;, Assignee: |
ImmunoConjucates for cancer diagnosis and therapy
What is claimed is: 1. A composition of matter comprising a 15A8 antibody conjugated to an amino group of a gelonin moiety. 2. A method of delivering toxin to breast cancer cells that express the 15A8... Read More
Inventors: Rosenblum, Michael G.; Dulbecco, Renato; Allen, W. Ross;, Assignee: Research Development Foundation (Carson City, NV) |
Synergistic composition of CD4-based protein and anti-HIV-1 antibody, and methods of using same
OF THE INVENTION The plasmids CD4-IgG.sub.1 HC-pRcCMV, CD4-kLC-pRcCMV, CD4IgG.sub.2 -pcDNA1 and CD4-IgG.sub.2 HC-pRcCMV were deposited pursuant to, and in satisfaction of, the requirements of the Bud... Read More
Inventors: Allaway, Graham P.; Maddon, Paul J.;, Assignee: Progenics Pharmaceuticals, Inc. (Tarrytown, NY) |
Methods and compositions for generating angiostatin
The present invention provides such a method. In particular, the invention provides a method of generating angiostatin in vitro comprising contacting plasminogen or plasmin with a plasminogen activato... Read More
Inventors: Soff, Gerald; Gately, Stephen T.; Twardowski, Przemyslaw;, Assignee: Northwestern University (Evanston, IL) |
Use of calcitonin gene-related peptide in the prevention and alleviation of asthma and related bronchospastic pulmonary diseases
The present invention relates to the use of calcitonin gene-related peptide (CGRP) in the prevention, reduction and/or alleviation of the pathophysiological manifestations of asthma. The invention fur... Read More
Inventors: Cadieux, Alain;, Assignee: Sherbrooke University (Quebec, CA) |
Luteinizing and follicle stimulating hormones and process for the preparation thereof
We claim: 1. Luteinizing and follicle stimulating hormone, capable of releasing factor analogs of high gonadotropic activity, of the formula ##STR5## wherein X is selected from the group consisting of... Read More
Inventors: Flegel, Martin; Pospisek, Jan; Picha, Josef; Pichova, Drahomira; Krojidlo, Milan; Kolinsky, Jiri;, Assignee: SPOFA, spojene podniky pro zdravotnickou vyrobu (Prague, CS) |
6-pen-vasopressin compounds
What is claimed is: 1. A polypeptide compound having the formula: ##STR7## in which: X is a D or L isomer of Ile, Phe(Alk), Tyr or Tyr(Alk); A is Pro or a single bond; B is a D or L isomer of Arg or L... Read More
Inventors: Moore, Michael L.;, Assignee: SmithKline Beckman Corporation (Philadelphia, PA) |
LHRH antagonists
We claim: 1. A peptide selected from the group of peptides having the formula: X-R.sup.1 -R.sup.2 -R.sup.3 -Ser-Tyr-R.sup.6 -Leu-Arg-Pro-R.sup.10 -NH.sub.2 wherein X is an acyl group derived from stra... Read More
Inventors: Schally, Andrew V.; Bajusz, Sandor;, Assignee: |
LHRH antagonists
We claim: 1. A peptide having the formula: X--R.sup.1 --R.sup.2 --R.sup.3 --Ser--Tyr--R.sup.6 --Leu--Arg--Pro--R.sup.10 --NH.sub.2 wherein X is acetyl, R.sup.1 is D-Nal(2), R.sup.2 is D-Phe(4Cl), R.su... Read More
Inventors: Schally, Andrew V.; Bajusz, Sandor;, Assignee: The Administrators of the Tulane Educational Fund (New Orleans, LA) |
Drugs 
