Opioid peptides derived from wheat proteins
It is therefore an object of the present invention to provide new opioid peptides having the specified amino acid sequence isolated from the hydrolysates of wheat proteins. It is further object of the... Read More
Inventors: Yoshikawa, Masaaki; Fukudome, Shin-ichi;, Assignee: Nisshin Flour Milling Co., Ltd. (Tokyo, JP) |
Products for administering an initial high dose of Cetrorelix and producing a combination package for use when treating diseases
We claim: 1. A kit comprising (a) an initial dose of an LHRH antagonist suitable for treatment of hormone-dependent conditions, and (b) at least one maintenance dose of the LHRH antagonist, in an amou... Read More
Inventors: Engel, Jurgen; Hilgard, Peter; Reissmann, Thomas;, Assignee: ASTA Medica Aktiengesellschaft (Dresden, DE) |
Ifosfamide lyophilizate preparations
OF PREFERRED EMBODIMENTS OF THE INVENTION The invention is presented in greater detail with the aid of the following working examples without, however, restricting it thereto. EXAMPLE 1 8 liters of w... Read More
Inventors: Wichert, Burkhard; Sauerbier, Dieter; Rawert, Jurgen;, Assignee: Asta Medica Aktiengesellschaft (Dresden, DE) |
Process to manufacture implants containing bioactive peptides
The present invention relates to a process for manufacturing pharmaceutical implants for the delivery of an effective amount of a bioactive peptide or peptide analog over a period of 1 to 12 months wh... Read More
Inventors: Deghenghi, Romano;, Assignee: |
Means for treating prostate cancer
The disclosed invention is directed to a long-lasting therapeutic agent having few side effects for the treatment of both BPH and prostate cancer. The problems existing with the treatments described a... Read More
Inventors: Engel, Jurgen; Reissmann, Thomas; Riethmuller-Winzen, Hilde; Rawert, Jurgen;, Assignee: ASTA Medica Aktiengesellschaft (DE) |
Process for the preparation of immobilized and activity-stabilized complexes of LHRH antagonists
The aim of the invention is to prepare depot preparations having improved and controllable release-delaying properties and increased stability against premature proteolytic degradation of LHRH antagon... Read More
Inventors: Engel, Jurgen; Deger, Wolfgang; Reissmann, Thomas; Losse, Gunter; Naumann, Wolfgang; Murgas, Sandra;, Assignee: Asta Medica Aktiengesellschaft (Dresden, DE) |
Thienopyrimidine compounds, their production and use
What is claimed is: 1. 5-(N-Benzyl-N-methylaminomethyl)-1-(2,6-difluorobenzyl)-6-[4-(3-methoxyure ido)phenyl]-3-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione or a salt thereof.
Description:
... Read More
Inventors: Furuya, Shuichi; Suzuki, Nobuhiro; Choh, Nobuo; Nara, Yoshi;, Assignee: Takeda Chemical Industries, Ltd. (Osaka, JP) |
LHRH antagonists having improved solubility properties
OF THE INVENTION The following examples serve to illustrate the invention without restricting it. EXAMPLE 1 Ac-D-Nal(2).sup.1 -D-Cpa.sup.2 -D-Pal(3).sup.3 -Ser.sup.4 -N-Me-Tyr.sup.5 -D-Hci.sup.6 -Nle... Read More
Inventors: Bernd, Michael; Kutscher, Bernhard; Gunther, Eckhard; Romeis, Peter; Reissmann, Thomas; Beckers, Thomas;, Assignee: Zentaris AG (Frankfurt/Main, DE) |
Treatment of AIDS with antibodies to gamma interferon, alpha interferon and TNF-alpha
What is claimed is: 1. A method of treating Acquired Immunodeficiency Disease in a patient comprising administering to said patient an effective amount of a combination of an antibody to gamma interfe... Read More
Inventors: Skurkovich, Boris; Skurkovich, Simon V.;, Assignee: Advanced Biotherapy, Inc. (Woodland Hills, CA) |
Hydrophobic oil absorbing polymers and process
We claim: 1. An oil-absorbing composition that absorbs at least 20 weight percent of at least one oily substance including hydrophobic material in a heterogeneous medium, based on the total weight of ... Read More
Inventors: Keenan, Andrea C.; Lau, Willie; Schwartz, Curtis;, Assignee: Rohm and Haas Company (Philadelphia, PA) |
Wet wipes containing a mono alkyl phosphate
OF THE INVENTION The present invention relates to fibrous materials and, in particular, wet wipes which have improved cleaning efficacy without, excessive skin irritation or foaming. The wet wipes of... Read More
Inventors: Cole, Douglas Bryan; Stahl, Katherine Denise;, Assignee: Kimberly-Clark Worldwide, Inc. (Neenah, WI) |
Predicting folded structures of proteins
In the method of the present invention, a model for the folded structure of a set of proteins is built from a set of aligned homologous protein sequences. The method of the present invention is charac... Read More
Inventors: Benner, Steven Albert;, Assignee: |
Mimetic insect allatostatin analogs for insect control
We have discovered novel pseudopeptide analogs of the insect allatostatin neuropeptide family which possess biological activity mimicking that of the naturally occurring neuropeptides. By addition of ... Read More
Inventors: Nachman, Ronald J.; Teal, Peter E. A.; Garside, Christopher S.; Tobe, Stephen S.;, Assignee: The United States of America as represented by the Secretary of Agriculture (Washington, DC) |
O-superfamily conotoxin peptides
OF THE PREFERRED EMBODIMENT The invention relates to relatively short peptides (termed O-Superfamily conotoxins herein), about 20-40 residues in length, which are naturally available in minute amount... Read More
Inventors: Olivera, Baldomero M.; Cartier, G. Edward; Watkins, Maren; Hillyard, David R.; McIntosh, J. Michael; Layer, Richard T.; Jones, Robert M.;, Assignee: University of Utah Research Foundation (Salt Lake City, UT); Cognetix, Inc. (Salt Lake City, UT) |
Aqueous solvent based encapsulation of a bovine herpes virus type-1 subunit vaccine
OF THE INVENTION Applicants have surprisingly discovered that the immunogenicity of a BHV-1 subunit component is dramatically increased by microencapsulation. Specifically, Applicants have discovered... Read More
Inventors: Speaker, Tully J.; Clark, H. Fred; Moser, Charlotte A.; Offit, Paul A.; Campos, Manuel; Frenchick, Patrick J.;, Assignee: Pfizer Inc. (New York, NY) |
DNA encoding a cholecystokinin receptor
It is therefore an object of the present invention to provide a method for obtaining CCK receptor protein, in a homogeneous form suitable for amino acid sequencing. It is also an object of the present... Read More
Inventors: Wank, Steven A.;, Assignee: The United States of America as represented by the Department of Health and (Washington, DC) |
Cellular fibronectin: polypeptides, anti-polypeptide antibodies and assay methods
The present invention contemplates a synthetic polypeptide that corresponds substantially in sequence to a portion of the amino acid residue sequence of human cellular fibronectin, antibodies to those... Read More
Inventors: Peters, John H.; Ginsberg, Mark H.; Cochrane, Charles G.;, Assignee: Scripps Clinic and Research Foundation (La Jolla, CA) |
Polypeptide fragments of fibronectin which can modulate extracellular matrix assembly
OF THE INVENTION In accordance with the present invention, there are provided novel polypeptide(s) characterized by: having a molecular weight of about 14 kDa, having the ability to bind fibronectin ... Read More
Inventors: Ruoslahti, Erkki I.; Morla, Alex;, Assignee: La Jolla Cancer Research Foundation (La Jolla, CA) |
Fibronectin binding protein polypeptides
We claim: 1. An isolated D1-D4 polypeptide from a Staphylococcus aureus Fibronectin binding protein, wherein said polypeptide comprises an amino acid sequence selected from the group consisting of SEQ... Read More
Inventors: Burnham, Martin Karl Russel; Chopra, Ian; Critchley, Ian Alfred; Knowles, David Justin Charles;, Assignee: Smithkline Beecham p.l.c. (Brentford, GB) |
Modified HCV peptide vaccines
OF THE INVENTION As used herein, "a" or "an" may mean one or more. For example, "a" cell may mean one cell or more than one cell. The present invention is based on the unexpected and surprising disco... Read More
Inventors: Berzofsky, Jay A.; Pendleton, C. David; Feinstone, Stephen M.; Major, Marian E.; Sarobe, Pablo;, Assignee: The United States of America as represented by the Department of Health and (Washington, DC) |
In vitro amplification of nucleic acid molecules via circular replicons
OF THE INVENTION I. Terminology of the Invention The present invention provides a method for amplifying a "target" polynucleotide region of a nucleic acid molecule that is present in a sample. Such s... Read More
Inventors: Auerbach, Jeffrey I.;, Assignee: Replicon, Inc. (Rockville, MD) |
Tumor necrosis factor receptor-I-associated protein kinase and methods for its use
The present invention uses a glutathione-S-transferase (GST) fusion protein containing the cytoplasmic domain of p60 (GST-p60CD.DELTA.1) linked to glutathione agarose to 1) identify proteins from cell... Read More
Inventors: Aggarwal, Bharat B.; Darnay, Bryant G.;, Assignee: Research Development Foundation (Carson City, NV) |
Technetium-99m labeled peptides for imaging
OF THE INVENTION The present invention provides reagents for preparing Tc-99m labeled peptides for imaging target sites within a mammalian body comprising a multiplicity of specific binding peptide h... Read More
Inventors: Dean, Richard T.; Lister-James, John;, Assignee: Diatide, Inc. (Londonderry, NH) |
Human Zven1 proteins
We claim: 1. An isolated polypeptide, comprising amino acid residues 23 to 108 of SEQ ID NO:2. 2. The isolated polypeptide of claim 1, comprising the amino acid sequence of SEQ ID NO:2. 3. The isolate... Read More
Inventors: Sheppard, Paul O.; Bishop, Paul D.;, Assignee: ZymoGenetics, Inc. (Seattle, WA) |
Immunogenic conjugates of streptococcus pneumonial capsular polymer and toxin or in toxiad
OF THE INVENTION The conjugates of the invention are formed by reacting reducing end groups of the capsular polymer fragment to primary amino groups of a bacterial toxin or toxoid to yield antigenic ... Read More
Inventors: Anderson, Porter W.; Eby, Ronald J.;, Assignee: The University of Rochester (Rochester, NY) |
Plasmid for production of CRM protein and diphtheria toxin
The invention pertains to a novel method and plasmid system for manipulating and introducing the gene encoding for CRM197, diphtheria toxin and other CRM proteins derived from the diphtheria toxin gen... Read More
Inventors: Metcalf, Benjamin J.;, Assignee: American Cyanamid Company (Madison, NJ) |
Cloned leptospira outer membrane protein
The present invention is based on the identification of OmpL1 as a major leptospiral outer membrane protein which is associated with pathogenic strains of Leptospira. Due to spirochetal outer membrane... Read More
Inventors: Haake, David A.; Blanco, David R.; Champion, Cheryl I.; Lovett, Michael A.; Miller, James N.;, Assignee: The Regents of the University of California (Oakland, CA) |
Adipocyte complement related protein homolog zacrp3
OF THE INVENTION Prior to setting forth the invention in detail, it may be helpful to the understanding thereof to define the following terms. The term "affinity tag" is used herein to denote a pepti... Read More
Inventors: Piddington, Christopher S.; Bishop, Paul D.;, Assignee: ZymoGenetics, Inc. (Seattle, WA) |
Protective monoclonal antibody compositions for infections due to group B streptococcus
What is claimed is: 1. A composition useful in the prophylactic or therapeutic treatment of bacterial infection due to group B streptococci, said composition comprising an in vivo protective monoclona... Read More
Inventors: Raff, Howard V.;, Assignee: Genetic Systems Corporation (Seattle, WA) |
Meningococcal polysaccharide conjugate vaccine
OF THE INVENTION The group B meningococcal polysaccharide is isolated from N. meningitidis by methods which are known in the art. In one such method, group B meningococci (strain 981B) were grown at ... Read More
Inventors: Jennings, Harold J.; Michon, Francis;, Assignee: National Research Council of Canada (Ottawa, CA) |
Drugs 
