Meningococcal polysaccharide conjugate vaccine
OF THE INVENTION The group B meningococcal polysaccharide is isolated from N. meningitidis by methods which are known in the art. In one such method, group B meningococci (strain 981B) were grown at ... Read More
Inventors: Jennings, Harold J.; Michon, Francis;, Assignee: National Research Council of Canada (Ottawa, CA) |
Antibodies that define unique Meningococcal B epitopes and vaccine compositions
OF THE INVENTION The practice of the present invention will employ, unless otherwise indicated, conventional methods of immunology, microbiology, molecular biology and recombinant DNA techniques with... Read More
Inventors: Granoff, Dan M.; Moe, Gregory R.;, Assignee: Chiron Corporation (Emeryville, CA); Children's Hospital Medical Center of Northern California (Oakland, CA) |
Endothelin-antagonizing peptide
What is claimed is: 1. A peptide represented by the following formula (I): X-A-Trp-B-Gly-Thr-E-G-Y (I) SEQ ID NO: 2 wherein A represents Asn or Asp; B represents His or Lys; E represents Ala or Ser; G... Read More
Inventors: Tanaka, Takeo; Morishita, Yoshikazu; Makino, Mika; Chiba, Shigeru; Kawamoto, Isao; Tsukuda, Eiji; Yoshida, Mayumi; Bando, Chieko; Yamaguchi, Kazuo; Matsuda, Yuzuru; Kitamura, Shigeto; Ikemura, Toshihide; Ogawa, Tatsuhiro; Yano, Keiichi; Suzawa, Toshiyuki;, Assignee: Kyowa Hakko Kogyo Co., Ltd. (Tokyo, JP) |
Bacillus strain and harmful organism controlling agents
The present inventors have found a novel strain producing a crystalline protein which has an excellent insecticidal activity against lepidopterous and coleopterous insects and attained the present inv... Read More
Inventors: Iizuka, Toshihiko; Tagawa, Michito; Arai, Satoshi; Niizeki, Masatsugu; Miyake, Toshiro;, Assignee: Nissan Chemical Industries, Ltd. (Tokyo, JP) |
Bacillus thuringiensis strains and their insecticidal proteins
OF THE INVENTION The BTS02618A protoxin of this invention can be isolated in a conventional manner from the BTS02617A strain, deposited on July, 2 at the BCCM-LMG under accession number LMG P-12592, ... Read More
Inventors: Lambert, Bart; Jansens, Stefan; Van Audenhove, Katrien; Peferoen, Marnix; Van Rie, Jeroen; Van Aarssen, Roel;, Assignee: Plant Genetic Systems N.V. (Brussels, BE) |
Bacillus thuringiensis strains and their insecticidal proteins
OF THE INVENTION The BTS02618A protoxin of this invention can be isolated in a conventional manner from the BTS02617A strain, deposited on July, 2 at the BCCM-LMG under accession number LMG P-12592, ... Read More
Inventors: Lambert, Bart; Jansens, Stefan; Van Audenhove, Katrien; Peferoen, Marnix;, Assignee: Plant Genetic Systems, N.V. (Brussels, BE) |
Toxins active against pests
What is claimed is: 1. A method for the control of a lepidopteran pest wherein said method comprises contacting said pest with a pesticidal amount of a Bacillus thuringiensis toxin, or a pesticidal po... Read More
Inventors: Schnepf, H. Ernest; Wicker, Carol; Narva, Kenneth E.; Walz, Michele; Stockhoff, Brian A.;, Assignee: Mycogen Corporation (Indianapolis, IN) |
Cloned streptococcal genes encoding protein G and their use to construct recombinant microorganisms to produce protein G
OF THE PREFERRED EMBODIMENTS The present invention relates to cloned Protein G genes. A DNA fragment comprising a Protein G gene is isolated from a Streptococcus Sp. Lancefield Group G, strain and in... Read More
Inventors: Fahnestock, Stephen R.;, Assignee: Genex Corporation (Gaithersburg, MD) |
Protein G and/or fragments thereof
A hybrid DNA molecule is produced comprising a vector into which has been introduced a DNA sequence coding for a protein capable of being expressed in a cell. The hybrid DNA molecule is characterized... Read More
Inventors: Bjorck, Lars; Kronvall, Goran; Lindahl, Gunnar; Kastern, William H.;, Assignee: Pharmacia LKB Biotechnology AB (SE) |
Bacterial plasmin receptors as fibrinolytic agents
OF THE INVENTION One of the major problems with plasminogen activator administration is the lytic state that accompanies injection of high concentrations of streptokinase or, to a lesser degree, tiss... Read More
Inventors: Boyle, Michael D. P.; Lottenberg, Richard; Broder, Christopher; Von Mering, Gregory;, Assignee: University of Florida Research Foundation, Inc. (Alachua, FL) |
Gamma antigen of pathogenic group B streptococci
This invention concerns novel bacterial pathogenic markers which can be used to identify organisms that are potentially to neonates. More specifically, the subject invention concerns novel bacterial m... Read More
Inventors: Boyle, Michael D. P.; Brady, L. Jeannine;, Assignee: University of Florida Research Foundation, Inc. (Gainesville, FL) |
Targeted immunostimulation with bispecific reagents
This invention pertains to a binding agent which binds a surface receptor of an antigen-presenting cell in some instances without being blocked substantially by the natural ligand for the receptor and... Read More
Inventors: Romet-Lemonne, Jean Loup; Fanger, Michael W.; Guyre, Paul M.; Gosselin, Edmund J.;, Assignee: Medarex, Inc. (Princeton, NJ) |
Human NIK proteins
OF THE INVENTION The nucleotide sequence of a natural human cDNA encoding a human NIK polypeptide is shown as SEQ ID NO:1, and the full conceptual translate is shown as SEQ ID NO:2. This novel NIK cD... Read More
Inventors: Rothe, Mike; Wu, Lin;, Assignee: Tularik Inc. (South San Francisco, CA) |
Noninvasive detection of colorectal cancer and other gastrointestinal pathology
OF THE INVENTION Various objects and advantages of the present invention are achieved by obtaining viable, homogeneous colonocytes of desired cell types isolated from a fecal sample at normal atmosph... Read More
Inventors: Nair, Padmanabhan P;, Assignee: |
Anti-alopecia composition
OF THE INVENTION Although useful as a hair grooming aid, the invention is broadly applicable to baldness in general, the above defined composition of matter may be especially useful for the treatment... Read More
Inventors: Harris, Bruce J.; Lawter, James R.; Ritter, Lawrence;, Assignee: American Cyanamid Co. (Stamford, CT) |
Use of CGRP in treating alopecia
OF THE PREFERRED EMBODIMENT Calcitonin levels are decreased in alopecia areata patients and this contributes to, or is the direct cause of, the hair loss. Calcitonin controls or plays a part in contr... Read More
Inventors: Daly, Theodore J.;, Assignee: |
Use of antiotensin II analogs in tissue repair
OF THE INVENTION Pursuant to the present invention, wound healing in mammalian tissue is promoted through the use of a composition comprising an effective amount of at least one compound of the gener... Read More
Inventors: Rodgers, Kathleen Elizabeth; Dizerega, Gere Stodder;, Assignee: University of Southern California (Los Angeles, CA) |
High affinity mutants of nuclear factor-interleukin 6 and methods of use therefor
Therefore, it is an object of the present invention to provide inhibitors of NF-IL6. In addition, it is an object of the present invention to provide methods for the use of such inhibitors in reducing... Read More
Inventors: Brasier, Allan R.;, Assignee: Board of Regents, The University of Texas System (Austin, TX) |
Use of angiotensin II fragments and analogs thereof in tissue repair
The present invention relates to the use of active fragments of AII and analogs thereof in wound healing. These compounds form the basis of compositions useful for accelerating wound healing, the comp... Read More
Inventors: Rodgers, Kathleen Elizabeth; diZerega, Gere Stodder;, Assignee: University of Southern California (Los Angles, CA) |
Medical use of an ace-inhibitor for treatment of dyspeptic symptoms
OF THE INVENTION It has surprisingly been found that antihypertensive treatment by use of an angiotensin converting enzyme (ACE) inhibitor decreases the frequency and severity of dyspeptic symptoms o... Read More
Inventors: Fandriks, Lars; Pettersson, Anders;, Assignee: Astra Aktiebolag (Sodertalje, SE) |
Method of promoting healing in skin grafts
One aspect of the invention relates to a method of promoting incorporation of a skin graft into underlying tissue of a mammal. This method includes the steps of: (1) applying to either the skin graft ... Read More
Inventors: Rodgers, Kathleen E.; DiZerega, Gere S.;, Assignee: University of Southern California (Los Angeles, CA) |
Method of promoting erythropoiesis
OF THE PREFERRED EMBODIMENTS All cited patents, patent applications and references are hereby incorporated by reference in their entirety. As defined herein, the term "erythropoiesis" refers to red b... Read More
Inventors: Rodgers, Kathleen E.; DiZerega, Gere;, Assignee: University of Southern California (Los Angeles, CA) |
Use of angiotensin II type 2 receptor agonists in tissue repair
OF THE INVENTION Pursuant to the present invention. wound healing in mammalian tissue is promoted through the use of a composition comprising an effective amount of at least one AT2 agonist. The acti... Read More
Inventors: Rodgers, Kathleen Elizabeth; Dizerega, Gere Stodder;, Assignee: University of Southern California (Los Angeles, CA) |
Wound healing compositions
A first aspect of the invention relates to a composition that is useful for accelerating wound healing. This composition includes a suitable carrier or diluent and an amount effective to accelerate wo... Read More
Inventors: Rodgers, Kathleen E.; DiZerega, Gere S.;, Assignee: University of Southern California (Los Angeles, CA) |
Peptidomimetic glutathione analogs
What is claimed is: 1. A compound of formula ##STR18## wherein Z.dbd.CH.sub.2 and Y.dbd.CH.sub.2, or Z.dbd.O and Y.dbd.CO.dbd.O, R.sub.1 and R.sub.2 are independently selected from the group consistin... Read More
Inventors: Burg, Danny; Mulder, Gerard Johan;, Assignee: Universiteit Leiden (Leiden, NL) |
Recombinant vaccine for porcine pleuropneumonia
In its most general and overall scope this invention discloses DNA sequences encoding for A. pleuropneumoniae hemolysin antigen. It further provides for recombinant vectors and recombinant cells conta... Read More
Inventors: Struck, Douglas K.; Young, Ryland F.; Chang, Yung-Fu;, Assignee: The Texas A&M University System (College Station, TX) |
Mycolactone and related compounds, compositions and methods of use
OF THE INVENTION The present invention provides an isolated polyketide macrolide that can be isolated from virulent isolates of Mycobacterium ulcerans. The polyketide macrolide has the formula of For... Read More
Inventors: Small, Pamela L. C.; George, Kathleen M.;, Assignee: The United States of America as represented by the Department of Health and (Washington, DC) |
Leptospira membrane proteins
The present invention presents two novel leptospiral membrane proteins: LipL1 and LipL2. In particular, these proteins are lipoproteins which are associated with pathogenic strains of Leptospira. LipL... Read More
Inventors: Haake, David A.; Shang, Ellen S.;, Assignee: The Regents of the University of California (Oakland, CA) |
Primary biliary cirrhosis autoantigen
Despite the paucity of data on mechanisms of anti-mitochondrial antibody formation, by enzyme-linked immunosorbent assay (ELISA), clinically more than 95% of patients with PBC can be found to have suc... Read More
Inventors: Coppel, Ross L.; Gershwin, Merrill E.;, Assignee: Amrad Corporation Limited (Abbotsford, AU) |
Nuclear antigen La
We claim: 1. A method for the detection of antinuclear antibody anti-La in a serum sample which comprises: (a) contacting said sample with a support having immobilized thereon a synthetic polypeptide ... Read More
Inventors: Coppel, Ross L.; Sturgess, Allan D.;, Assignee: Amrad Corporation Limited (Victoria, AU) |
Drugs 
