Self-aligning peptides modeled on human elastin and other fibrous proteins
OF PREFERRED EMBODIMENTS The present invention is directed to unique polypeptides modeled on human elastin and other naturally occurring fibrous proteins. While the discussion below often refers to h... Read More
Inventors: Rothstein, Aser; Keely, Fred W.; Rothstein, Steven J.;, Assignee: The Hospital for Sick Children (Toronto, CA); Protein Specialties, Ltd. (Toronto, CA) |
Prosthetic devices including elastin or elastin-based materials
It is a specific object of the invention to provide an elastin-based prosthetic device suitable for use as a stent, for example, a vascular stent. The present invention relates to a method of repairin... Read More
Inventors: Gregory, Kenton W.;, Assignee: Kenton W. Gregory & Sisters of Providence (Portland, OR) |
Peptides containing N-substituted L-amino acids for preventing .beta.-strand association
The invention claimed is: 1. A peptide comprising a peptide, wherein: (a) said peptide comprises a .beta.-strand-forming section, said section consisting of four to sixteen consecutive .alpha.-L-amino... Read More
Inventors: Stott, Kelvin;, Assignee: Senexis Limited (Manchester, GB) |
Lectins and antiretroviral drugs containing the lectins as active ingredient
OF THE INVENTION The lectins of the present invention are obtained from the plants of the class Dicotyledoneae and have a function for inhibiting the reverse transcriptase activity as well as an inhi... Read More
Inventors: Sugita, Norifumi; Niimura, Koichi; Oguchi, Yoshiharu; Hirose, Kunitaka; Matsunaga, Kenichi; Oohara, Minoru; Muto, Shigeaki; Kakuchi, Junji; Furusho, Takao; Yoshikumi, Chikao; Takahashi, Masaaki;, Assignee: Kureha Kagaku Kogyo Kabushiki Kaisha (Tokyo, JP) |
Activated dendritic cells and methods for their activation
The present invention pertains to a method of activating dendritic cells to enhance antigen presenting capacity. The activated, antigen-presenting dendritic cells of the invention are useful as vaccin... Read More
Inventors: Maraskovsky, Eugene; Mc Kenna, Hilary J.;, Assignee: Immunex Corporation (Seattle, WA) |
Methods and compositions for obtaining mature dendritic cells
OF THE INVENTION This invention relates to methods and compositions useful for promoting the maturation of immature dendritic cells to a mature and stable phenotype as well as to the stable mature de... Read More
Inventors: Steinman, Ralph M.; Bhardwaj, Nina; Schuler, Gerold;, Assignee: The Rockefeller University (New York, NY) |
Nucleic acid encoding a lectin-derived progenitor cell preservation factor
It has now been discovered that these and other objectives can be achieved by the present invention, which provides an isolated nucleic acid comprising a nucleotide sequence as defined by SEQ ID NO:1,... Read More
Inventors: Colucci, M. Gabriella; Chrispeels, Maarten J.; Moore, Jeffrey G.;, Assignee: ImClone Systems Incorporated (New York, NY) |
Ligand for vascular endothelial growth factor receptor
We claim: 1. A compound comprising amino acid sequence Glu-Ile-Glu-Trp-Tyr-Ser-Trp-Val-Thr-His-Gly-Met-Tyr (SEQ ID NO:29). 2. A pharmaceutical composition comprising the compound of claim 1 and a bio... Read More
Inventors: Tchistiakova, Lioudmila; Li, Shengmin; Pietrzynski, Grzegorz; Alakhov, Valery;, Assignee: Supratek Pharma Inc. (CA) |
Immunologically active proteins from Borrelia burgdorferi, nucleic acids which encode them, and their use in test kits and as vaccines
What is claimed is: 1. An immunologically active Borrelia burgdorferi protein free of other proteins isolated from Borrelia burgdorferi, which protein comprises SEQ ID NO: 1, or at least 25 consecutiv... Read More
Inventors: Motz, Manfred; Soutschek, Erwin;, Assignee: Mikrogen Molekularbiologische Entwicklungs - GmbH (Munich, DE) |
Immunoliposomes that optimize internalization into target cells
The present invention provides novel immunoliposomes optimized for delivering therapeutic agents to the cytoplasm of a target cell. These immunoliposomes exhibit increased half-life in blood, are capa... Read More
Inventors: Benz, Christopher C.; Papahadjopoulos, Demetrois; Park, John W.; Hong, Keelung; Kirpotin, Dmitri;, Assignee: The Regents of the University of California (Oakland, CA) |
Virus-like particles for the induction of autoantibodies
The inventors have discovered compositions and methods of increasing the titers of antibodies to tolerogens (e.g., self antigens and foreign antigens) over those titers routinely generated spontaneous... Read More
Inventors: Schiller, John T.; Chackerian, Bryce; Lowy, Douglas R.;, Assignee: The United States of America as represented by the Department of Health and (Washington, DC) |
Ferritin analogs
Despite the fact that ferritin is extremely selective in accumulating, storing and dispensing iron in living things, I have discovered that the forgoing objectives can be realized by inserting any of ... Read More
Inventors: Monzyk, Bruce F.;, Assignee: Monsanto Company (St. Louis, MO) |
Methods of treatment using anti-ErbB antibody-maytansinoid conjugates
What is claimed is: 1. A method for the treatment of a tumor in a mammal, comprising the steps of (i) identifying said tumor as being characterized by overexpression of an ErbB2 receptor and as being ... Read More
Inventors: Erickson, Sharon; Schwall, Ralph; Sliwkowski, Mark; Blattler, Walter;, Assignee: Genentech, Inc. (South San Francisco, CA) Immunogen, Inc. (Cambridge, MA) |
Methods for diagnosing early Lyme disease
This invention is based upon the discovery that sera from patients with early Lyme disease contain predominant IgM reactivity to a major 23 kDa protein (p23; also referred to herein as OspC) from Borr... Read More
Inventors: Padula, Steven J.;, Assignee: University of Connecticut (Storrs, CT) |
Tango 243 polypeptides and uses thereof
The present invention is based, at least in part, on the discovery of cDNA molecules which encode the TANGO 228, 240, and 243 proteins, all of which are either wholly secreted or transmembrane protein... Read More
Inventors: Fraser, Christopher C.;, Assignee: Millennium Pharmaceuticals, Inc. (Cambridge, MA) |
Dermatophagoides proteins and fragments thereof
What is claimed is: 1. An isolated protein comprising an amino acid sequence selected from the group consisting of SEQ ID NO:15, SEQ ID NO:18 and SEQ ID NO:21. 2. A composition comprising the isolate... Read More
Inventors: McCall, Catherine A.; Hunter, Shirley Wu; Weber, Eric R.;, Assignee: Heska Corporation (Loveland, CO) |
Tuberculin active proteins and peptides from the cells of tubercle bacilli
What is claimed is: 1. A tuberculin active simple protein from Mycobacterium tuberculosis strain Aoyama B which is characterized by the following amino acid sequence: ##EQU3## wherein Asn and Gln repr... Read More
Inventors: Tsumita, Toru; Kuwabara, Seishi;, Assignee: Mitsui Pharmaceuticals, Incorporated (Tokyo, JA) |
Therapy for injured muscles
We claim: 1. A method for treating an injured muscle, the method comprising the step of local administration of a therapeutically effective amount of a botulinum toxin to an injured muscle, thereby fa... Read More
Inventors: Brooks, Gregory F.; Aoki, Kei Roger;, Assignee: Allergan, Inc. (Irvine, CA) |
Secreted and transmembrane polypeptides and nucleic acids encoding the same
1. PRO1560 A cDNA clone (DNA19902-1669) has been identified that encodes a novel polypeptide believed to be a novel member of the tetraspan family, designated in the present application as "PRO1560." ... Read More
Inventors: Eaton, Dan L.; Goddard, Audrey; Godowski, Paul J.; Gurney, Austin L.; Wood, William I.;, Assignee: Genentech, Inc. (South San Francisco, CA) |
HIV-specific cytotoxic T-cell responses
OF INVENTION The inventors have found that two nanomer peptides, designated CLP-177 (SEQ ID NO:2) and CLP-72 (SEQ ID NO:8), a hexamer designated CLP-178 (SEQ ID NO:3), and a 12-mer designated CLP-182... Read More
Inventors: Sia, Charles D. Y.; Chong, Pele; Klein, Michel H.;, Assignee: Sanofi Pasteur Limited (Toronto, CA) |
Method of immunomodulatory treatment of insulin dependent diabetes mellitus using mycobacterial cell wall compositions
OF PREFERRED EMBODIMENTS The present invention contemplates a method of immunomodulatory therapy in a mammal said method comprising administering to said mammal an immunomodulating effective amount o... Read More
Inventors: Baxter, Alan George;, Assignee: Centenary Institute of Cancer Medicine and Cell Biology (Camperdown, GB) |
Susceptibility mutation for breast and ovarian cancer
OF THE PREFERRED EMBODIMENTS The present invention is based on the discovery of a two base pair deletion of nucleotides 3888 and 3889 of the published BRCA1 cDNA sequence. This deletion mutation is r... Read More
Inventors: White, Marga B.; Sadzewicz, Lisa K.;, Assignee: OncorMed, Inc. (Gaithersburg, MD) |
Avirulent herpetic viruses useful as tumoricidal agents and vaccines
The present invention provides a herpetic virus selected from the group consisting of neurotrophic herpes viruses, T-lymphotrophic viruses, and B-lymphotrophic viruses having a genome from which the g... Read More
Inventors: Mohr, Ian J.; Gluzman, deceased, Yakov;, Assignee: American Cyanamid Company (Madison, NJ) |
Attachment enhanced 293 cells
In one aspect, the invention provides improved HEK 293 cells, which cells are 293 cells which have been transfected with a mammalian macrophage scavenger receptor gene. Preferably, this gene is the hu... Read More
Inventors: Lysko, Paul G.; Elshourbagy, Nabil A.; Brawner, Mary E.;, Assignee: SmithKline Beecham Corporation (Philadelphia, PA) |
Method for the production of polypeptides
The above identified purpose is achieved with the method according to the present invention which comprises culturing a yeast which has reduced activity of Yap3 protease (Yap3p) or a homologue thereof... Read More
Inventors: Egel-Mitani, Michi; Brandt, Jakob; Vad, Knud;, Assignee: Novo Nordisk A/S (Bagsv.ae butted.rd, DK) |
Silver halide emulsions with recombinant collagen suitable for photographic application and also the preparation thereof
What is claimed is: 1. A tabular silver halide emulsion wherein the tabular grains account for more than 75% of the total grain projected area said emulsion comprising silver halide grains nucleated i... Read More
Inventors: Van Heerde, George Valentino; Van Rijn, Alexis Cornelus; Bouwstra, Jan Bastiaan; De Wolf, Frederik Anton; Mooibroek, Andreas; Werten, Marc Willem Theodoor; Wind, Richele Deodata; Van Den Bosch, Tanja Jacoba;, Assignee: Fuji Photo Film B.V. (Tilburg, NL) |
DNA sequences coding for a protein conferring male sterility
Thus, in a first aspect the present invention provides recombinant or isolated Nucleic acid which: a) encodes the Ms41-A protein from Arabidopsis; b) encodes a Ms41-A like protein; c) encodes the ms41... Read More
Inventors: Baudot, Gaelle; Garcia, Denise; Hodge, Rachel; Perez, Pascual;, Assignee: Gene Shears Pty. Ltd. (Canberra Act, AU) |
Tumor associated nucleic acids and uses therefor
OF THE INVENTION The examples which follow show the isolation of nucleic acid molecules which code for polypeptides and are expressed preferentially in tumor cells, i.e. which are tumor associated ge... Read More
Inventors: Martelange, Valerie; De Smet, Charles; Boon-Falleur, Thierry;, Assignee: Ludwig Institute for Cancer Research (New York, NY) |
Mad-related genes in the human
It is an object of the invention to provide a cDNA of the human Smad2 gene. It is another object of the invention to provide an isolated Smad2 human protein. It is yet another object of the invention ... Read More
Inventors: Vogelstein, Bert; Kinzler, Kenneth W.; Riggins, Gregory R.; Thiagalingam, Sam;, Assignee: The Johns Hopkins University (Baltimore, MD) |
Tumor associated nucleic acids and uses therefor
OF THE INVENTION The examples which follow show the isolation of nucleic acid molecules which code for polypeptides and are expressed preferentially in tumor cells, i.e. which are tumor associated ge... Read More
Inventors: Martelange, Valerie; De Smet, Charles; Boon-Falleur, Thierry;, Assignee: Ludwig Institute for Cancer Research (New York, NY) |
Drugs 
