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Results: 91-120 of 3116
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Computer-aided display for comparative gene expression
The present invention provides innovative systems and methods for visualizing information collected from analyzing samples. The samples may include nucleic acids, proteins, or other polymers. Gene exp... Read More
Inventors: Mack, David H.; Khurgin, Elina; Dai, Josie; Gish, Kurt; Snyder, Jim; Balaban, David;, Assignee: Affymetrix, Inc. (Santa Clara, CA) |
Polymorphic repeats in human genes
OF PARTICULAR EMBODIMENTS OF THE INVENTION The following descriptions of particular embodiments and examples are offered by way of illustration and not by way of limitation. The invention provides to... Read More
Inventors: Garner, Harold R.; Wren, Jonathan D.; Minna, John D.; Fondon, III, John W.;, Assignee: Board of Regents, The University of Texas System (Austin, TX) |
Semaphorin gene: Semaphorin Y
What is claimed is: 1. An isolated nucleic acid molecule comprising a polynucleotide having a nucleotide sequence selected from the group consisting of: (a) the nucleotide sequence of SEQ ID NO: 1, (b... Read More
Inventors: Kimura, Toru; Kikuchi, Kaoru;, Assignee: Sumitomo Pharmaceuticals Company, Limited (Osaka-fu, JP) |
Non-maltogenic exoamylases and their use in retarding retrogradation of starch
What is claimed is: 1. A process for making a bakery product comprising: (a) adding to a starch medium a non-maltogenic exoamylase that hydrolyses starch by cleaving off one or more linear malto-oligo... Read More
Inventors: Kragh, Karsten M.; Larsen, Bjarne; Rasmussen, Preben; Duedahl-Olesen, Lene; Zimmermann, Wolfgang;, Assignee: Danisco A/S (Copenhagen, DK) |
Attenuated equine herpesvirus
The first objective of the present invention is achieved by an Equine herpesvirus (EHV) mutant, comprising one or more deletions, substitutions or insertions in the endogenous promoter region of an es... Read More
Inventors: Sondermeijer, Paulus Jacobus Antonius; Visser, Nicolaas N.; Dhore, Cherida Rachel;, Assignee: Akzo Nobel N.V. (Arnhem, NL) |
Conserved yeast nucleic acid sequences
OF THE INVENTION The present invention advantageously provides both probes and primers which bind to a variety of strains of C. albicans and C. stellatoidea. General probes are useful as an initial s... Read More
Inventors: Hoyer, Lois L.; Livi, George P.; Shatzman, Allan R.;, Assignee: SmithKline Beecham Corporation (Philadelphia, PA) |
Compositions and methods for the therapy and diagnosis of prostate cancer
Briefly stated, the present invention provides compositions and methods for the diagnosis and therapy of cancer, such as prostate cancer. In one aspect, the present invention provides polypeptides com... Read More
Inventors: Xu, Jiangchun; Dillon, Davin C.; Mitcham, Jennifer L.; Harlocker, Susan L.; Jiang, Yuqiu; Kalos, Michael D.; Fanger, Gary R.; Retter, Marc W.; Stolk, John A.; Day, Craig H.; Vedvick, Thomas S.; Carter, Darrick; Li, Samuel X.; Wang, Aijun; Skeiky, Yasir A., Assignee: Corixa Corporation (Seattle, WA) |
Compositions structured with at least one polymer and methods of using the same
What is claimed is: 1. A structured cosmetic composition comprising: (i) at least one continuous liquid fatty phase, wherein said at least one continuous liquid fatty phase is structured with a suffic... Read More
Inventors: Ferrari, Ve; Simon, Pascal;, Assignee: L'Oreal S.A. (Paris, FR) |
Synthetic peptides with bactericidal activity and endotoxin neutralizing activity for gram negative bacteria and methods for their use
OF THE INVENTION The invention provides for peptides derived from a neutrophil bacterial permeability protein (B/PI). The peptides are those that are biologically active for bacterial killing or endo... Read More
Inventors: Gray, Beulah; Haseman, Judith R.; Mayo, Kevin;, Assignee: Regents of the University of Minnesota (Minneapolis, MN) |
Therapeutic uses of bactericidal/permeability-increasing protein dimer products
The present invention provides significant improvements in therapeutic uses of BPI protein products through the provision of product formulations which include BPI protein products in the form of phys... Read More
Inventors: Ammons, William Steve; Little, Roger G.;, Assignee: XOMA Corporation (Berkeley, CA) |
Synthesis of soluble .beta.-sheet forming peptides
OF THE INVENTION An intricate interplay exists between peptide .beta.-sheet formation, self-association, and water solubility. A challenge in making a soluble folded peptide is that solubility has a ... Read More
Inventors: Mayo, Kevin; Griffioen, Arjan W.;, Assignee: Regents of the University of Minnesota (Minneapolis, MN) |
Flavivirus antigen
What is claimed is: 1. An antigen consisting essentially of an amino acid sequence represented by the following formula (I): Phe Asn Cys Leu Gly Met Gly Asn Arg Asp Phe Ile Glu Gly Ala Ser Gly Ala Thr... Read More
Inventors: Fujita, Hiroyuki; Yoshida, Iwao; Takagi, Mitsuo; Manabe, Sadao; Fukai, Konosuke;, Assignee: The Research Foundation for Microbial Diseases of Osaka University (Osaka, JP) |
Poxvirus containing formulations and process for preparing stable poxvirus containing compositions
OF THE INVENTION The present invention provides poxvirus containing formulation, in particular an aqueous poxvirus containing formulation. The formulation, in particular the aqueous formulation may b... Read More
Inventors: Howley, Paul; Heller, Karl; Rathe, Ingmar;, Assignee: Bavarian Nordic A/S (Kvistgaard, DK) |
Screening method for orthopoxvirus antivirals
What is claimed is: 1. An assay comprising the steps of: infecting cultured cells with vaccinia virus; co-transfecting the cells with one or more plasmids comprising DNA encoding the I7L protease enzy... Read More
Inventors: Hruby, Dennis E.; Bolken, Tove C.; Byrd, Chelsea;, Assignee: Siga Technologies, Inc. (New York, NY) |
Fibrinogen receptor antagonists
OF THE INVENTION Compounds of the invention are fibrinogen receptor antagonists which inhibit fibrinogen induced platelet aggregation. These compounds are prepared by solid phase synthesis which is w... Read More
Inventors: Nutt, Ruth F.; Brady, Stephen F.; Veber, Daniel F.;, Assignee: Merck & Co., Inc. (Rahway, NJ) |
Cyclic peptides containing Arg-Gly-Asp, and derivatives thereof, as adhesion inhibitors
We claim: 1. A cyclopeptide compound of formula I cyclo-(Arg-B-Asp-D-E) I, wherein: B is Gly, Ala, or--HN--Q--CO--; D is Phe, 4-Hal-Phe, Nal, or Phig; E is Gly, Ala, Lys, Lys(Ac), Lys(AcNH.sub.2), or ... Read More
Inventors: Jonczyk, Alfred; Holzemann, Gunter; Felding-Habermann, Brunhilde; Rippmann, Friedrich; Diefenbach, Beate; Kessler, Horst; Haubner, Roland; Wermuth, Jochen;, Assignee: Merck Patent Gesellschaft mit beschrankter Haftung (DE) |
Platelet aggregation inhibitors
We claim: 1. A method of treating or preventing a platelet associated ischemic disorder in a patient comprising administering to said patient an effective amount of a platelet aggregation inhibitor of... Read More
Inventors: Scarborough, Robert M.; Wolf, David Lawrence; Charo, Israel F.;, Assignee: COR Therapeutics, Inc. (South San Francisco, CA) |
Adhesion receptor antagonists
What is claimed is: 1. An oxazolidinone compound of formula I ##STR10## wherein R.sup.1 is ##STR11## R.sup.2 is H, A, Ac, A--SO.sub.2 --, Ar--SO.sub.2 -- or the amino protective group, BOC; R.sup.3 is... Read More
Inventors: Gante, Joachim; Juraszyk, Horst; Raddatz, Peter; Wurziger, Hanns; Bernotat-Danielowski, Sabine; Melzer, Guido; Wiesner, Matthias; Fittschen, Claus;, Assignee: Merck Patent Gesellschaft mit berschrankter Haftung (DE) |
Activation of peptide prodrugs by hK2
What is claimed is: 1. A composition comprising a prodrug, the prodrug comprising a therapeutically active drug; and a peptide comprising an amino acid sequence having a cleavage site specific for an ... Read More
Inventors: Denmeade, Samuel R.; Isaacs, John T.; Lilja, Hans;, Assignee: Denmeade; Samuel (Ellicott City, MD) Isaacs; John Tod (Pheonix, MD) Lilja; Hans (SE) |
Device having diarrhea diagnostic panel
The present invention is directed to a device that comprises a sensor adapted to detect one or more specific health and/or nutrition markers in feces. The device may also signal the caretaker of the o... Read More
Inventors: Roe, Donald C.;, Assignee: The Procter & Gamble Company (Cincinnati, OH) |
Method for the treatment of chemonucleolysis
A method of this invention involves a treatment comprising administering to a mammal in need of chemonucleolysis an effective proteoglycan cleaving amount of a proteoglycan-degrading enzyme; and an am... Read More
Inventors: Masuda, Koichi; Thonar, Eugene J-M. A.; An, Howard;, Assignee: |
Monoclonal antibodies that block ligand binding to the CD22 receptor in mature B cells
The present invention provides such monoclonal antibodies, HB22, which identify a region of the CD22 receptor that is distinct from those defined by previously described CD22 monoclonal antibodies (mA... Read More
Inventors: Tedder, Thomas F.; Engel, Pablo;, Assignee: Dana-Farber Cancer Institute, Inc. (Boston, MA) |
PRO1312 polypeptides
1. PR0281 A cDNA clone (DNA16422-1209) has been identified, having homology to nucleic acid encoding testis enhanced gene transcript (TEGT) protein that encodes a novel polypeptide, designated in the ... Read More
Inventors: Desnoyers, Luc; Goddard, Audrey; Godowski, Paul J.; Gurney, Austin L.; Wood, William I.;, Assignee: Genentech, Inc. (South San Francisco, CA) |
Purified p75 (type II) tumor necrosis factor receptor polypeptides
The present invention provides isolated TNF receptors and DNA sequences encoding mammalian tumor necrosis factor receptors (TNF-R), in particular, human TNF-Rs. Such DNA sequences include (a) cDNA clo... Read More
Inventors: Smith, Craig A.; Goodwin, Raymond G.; Beckmann, M. Patricia;, Assignee: Immunex Corporation (Seattle, WA) |
Derivatives of choline binding proteins for vaccines
OF THE INVENTION In accordance with an aspect of the present invention there is provided a vaccine to produce a protective response against S. pneumoniae infections which employs a polypeptide which ... Read More
Inventors: Wizemann, Theresa M.; Koenig, Scott; Johnson, Leslie S.;, Assignee: MedImmune, Inc. (Gaithersburg, MD) |
Pneumococcal protein homologs and fragments for vaccines
OF THE INVENTION The present invention is directed to novel polynucleotides and polypeptides derived from species of gram positive bacteria, especially group A and B streptococci, and including the g... Read More
Inventors: Koenig, Scott; Heinrichs, Jon; Johnson, Leslie S.; Adamou, John E.;, Assignee: Medimmune, Inc. (Gaithersburg, MD) |
Bv8 nucleic acids and polypeptides with mitogenic activity
The present invention is based on the identification of novel activities of Bv8. In particular, Bv8 has been found to induce proliferation in endothelial cells, to promote survival of endothelial cell... Read More
Inventors: Ferrara, Napoleone; Le Couter, Jennifer;, Assignee: Genentech, Inc. (South San Francisco, CA) |
Four genetic tumor markers specific for human glioblastoma
We claim: 1. A method of specifically delivering a reagent to a glioblastoma, comprising the step of: contacting cells of the glioblastoma with an antibody which is conjugated to a reagent, wherein th... Read More
Inventors: Riggins, Gregory J.; Lal, Anita; Loging, William T.;, Assignee: Duke University (Durham, NC) |
Streptococcus pneumoniae 37-kDa surface adhesin a protein
OF THE INVENTION The present invention may be understood more readily by reference to the following detailed description of the preferred embodiments of the invention and the Examples included therei... Read More
Inventors: Sampson, Jacquelyn; Russell, Harold; Tharpe, Jean A.; Ades, Edwin W.; Carlone, George M.;, Assignee: The Government of the United States of America, as represented by the Secretary, (Washington, DC) |
Peptides stimulating cytotoxic T cells immune to HIV RT
We claim: 1. A peptide consisting essentially of the following amino acid sequence: Cys-Thr-Glu-Met-Glu-Lys-Glu-Gly-Lys-Ile-Ser-Lys-Ile-Gly-Pro. 2. A peptide consisting essentially of the following am... Read More
Inventors: Berzofsky, Jay A.; Hosmalin, Anne; Clerici, Mario S.; Germain, Ronald N.; Shearer, Gene; Moss, Bernard; Pendleton, Charles D.;, Assignee: The United States of America as represented by the Department of Health (Washington, DC) |
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