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| Latest patents |
Results: 121-150 of 3116
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Molecularly cloned acquired immunodeficiency syndrome polypeptides and methods of use
In accordance with this invention, DNA encoding AIDS-associated polypeptides is identified and employed in recombinant prokaryotic or mammalian cell culture systems to synthesize predetermined AIDS-as... Read More
Inventors: Berman, Phillip W.; Capon, Daniel J.; Lasky, Laurence A.;, Assignee: Genentech, Inc. (San Francisco, CA) |
Method of evaluating HTLV-I-specific T cell responses
OF THE INVENTION It is the purpose of this invention to provide immunogenic peptides for use as vaccines to elicit T-cell immunity against HTLV-I. It is a further purpose of the invention to provide ... Read More
Inventors: Berzofsky, Jay A.; Kurata, Akihiko;, Assignee: The United States of America as represented by the Department of Health (Washington, DC) |
Multideterminant peptide antigens
It is one object of the present invention to demonstrate a process for the selection of synthetic peptides that are useful candidates for vaccines against HIV. Furthermore, a set of particular peptide... Read More
Inventors: Berzofsky, Jay A.;, Assignee: The United States of America as represented by the Department of Health (Washington, DC) |
HIV envelope polypeptides
The present invention provides a method for the rational design and preparation of vaccines based on HIV envelope polypeptides. This invention is based on the discovery that there are neutralizing epi... Read More
Inventors: Berman, Phillip W.; Nakamura, Gerald R.;, Assignee: Genentech, Inc. (South San Francisco, CA) |
Anti-HIV compositions containing native and recombinant peptides
OF THE INVENTION Various objects and advantages of the present invention are achieved by compositions and methods of preventing and treating HIV infection. The compositions comprise native HIV envelo... Read More
Inventors: Fischinger, Peter J.; Wong-Stall, Flossie; Gallo, Robert C.; Matthews, Thomas J.; Bolognesi, Dani P.; Robey, Gerard W.; Krohn, Kai; Ranki, Annamarie;, Assignee: The United States of America as represented by the Secretary of the (Washington, DC) |
HIV immunoassays using gag polypeptides
Nucleotide sequences and expression of nucleotide sequences are provided for detecting the presence of complementary sequences associated with a retroviral etiologic agent (HIV, e.g., HIV-1 or -2) for... Read More
Inventors: Luciw, Paul A.; Dina, Dino; Steimer, Kathelyn; Pescador, Ray Sanchez; George-Nascimento, Carlos; Parkes, Deborah; Hallewell, Rob; Barr, Philip J.; Truett, Martha;, Assignee: Chiron Corporation (Emeryville, CA) |
Prevention and treatment of amyloidogenic disease
I. General Several amyloidogenic diseases and conditions are characterized by presence of deposits of A.beta. peptide aggregated to an insoluble mass in the brain of a patient. Such diseases include ... Read More
Inventors: Schenk, Dale B.;, Assignee: Neuralab Limited (BM) |
HIV vaccine
What is claimed is: 1. A recombinant human immunodeficiency virus-1 (HIV-1), wherein the natural signal sequence (NSS) of the HIV-1 envelope glycoprotein gp120 of the virus is replaced with a signal s... Read More
Inventors: Kang, Chil-Yong; Li, Yan;, Assignee: University of Western Ontario (London, CA) |
Isolated nucleic acid encoding seven transmembrane receptors
The present invention is illustrated by the following examples relating to the isolation of human genomic and cDNA sequences encoding the novel 7TM receptors herein designated V28, V31, V112, R20, R2... Read More
Inventors: Godiska, Ronald; Gray, Patrick W.; Schweickart, Vicki Louise;, Assignee: ICOS Corporation (Bothell, WA) |
TIE-2 ligands, methods of making and uses thereof
What is claimed is: 1. An isolated antibody which specifically binds a ligand wherein the ligand consists of the amino acid sequence of SEQ ID NO: 2. 2. The antibody of claim 1 which is a monoclonal ... Read More
Inventors: Davis, Samuel; Bruno, Joanne; Goldfarb, Mitchell; Aldrich, Thomas H.; Maisonpierre, Peter C.; Radziejewski, Czeslaw; Jones, Pamela F.; Yancopoulos, George D.;, Assignee: Regeneron Pharmaceuticals, Inc. (Tarrytown, NY) |
Phthalidyl-isoquinoline derivatives
We claim: 1. A compound of the formula ##STR6## wherein each of R.sub.1, R.sub.2, R.sub.4, R.sub.5 and R.sub.6 is lower alkoxy; R.sub.3 is hydrogen or lower alkoxy; and R.sub.7 is lower alkyl or a dia... Read More
Inventors: Chazerain, Jacques A.; Cotereau, Hubert Y.; Lallouette, Pierre H.; Legger, Hugues A.; Lepape, Pierre A. C.;, Assignee: Laborec Laboratoire de Recherches Biologiques (Asnieres, FR); Calaire Chimie, S.A. (Calais, FR) |
Immune suppressive product
What is claimed is: 1. An oral vaccine, wherein said vaccine comprises a composition wherein said composition comprises a non-antibody fraction of milk and wherein said non-antibody fraction of milk a... Read More
Inventors: Beck, Lee R.; Stolle, Ralph J.;, Assignee: Stolle Research & Development Corporation (Cincinnati, OH) |
Anti-allergy anti-inflammatory composition
OF THE INVENTION The following unique features of Nimesulide may prove to be quite beneficial in all allergic disorders. 1) Nimesulide is a potent stabilizer of mast cells and basophils. Thus, it pre... Read More
Inventors: Singh, Amarjit; Jain, Rajesh;, Assignee: Panacea Biotec Limited (New Delhi, IN) |
Dermatophagoides nucleic acid molecules, proteins and uses thereof
OF THE INVENTION The present invention provides for isolated proteins having molecular weights ranging from about 60 kilodaltons (kD) to about 109 kD, that include at least one epitope of a protein a... Read More
Inventors: McCall, Catherine A.; Hunter, Shirley Wu; Weber, Eric R.;, Assignee: Heska Corporation (Fort Collins, CO) |
Stabilized primate lentivirus envelope glycoproteins
OF THE INVENTION We have discovered a series of novel polypeptides that can (1) enhance the immunogenicity of primate lentivirus envelope proteins for certain conserved epitopes, (2) generate a great... Read More
Inventors: Sodroski, Joseph G; Wyatt, Richard T.; Kwong, Peter D.; Hendrickson, Wayne A.; Farzan, Michael;, Assignee: Dana-Farber Cancer Institute, Inc. (Boston, MA) The Trustees of Columbia University in the City of New York (New York, NY) |
Endothelial-monocyte activating polypeptide III antibodies
What is claimed is: 1. An isolated antibody or fragment thereof that specifically binds to a protein whose amino acid sequence consists of amino acid residues 1 to 168 of SEQ ID NO:2. 2. The antibody ... Read More
Inventors: Coleman, Timothy A.; Rosen, Craig A.;, Assignee: Human Genome Sciences, Inc. (Rockville, MD) |
Bacillus thuringiensis toxins active against scarab pests
We claim: 1. An isolated polynucleotid encoding a toxin which is active against scarab pests, said polynucleotide encoding the amino acid sequence of SEQ ID NO. 4 or a fragment thereof sufficient to r... Read More
Inventors: Michaels, Tracy E.; Narva, Kenneth E.; Foncerrada, Luis;, Assignee: Mycogen Corporation (San Diego, CA) |
Growth differentiation factor-8 transgenic mice
The present invention provides a cell growth and differentiation factor, GDF-8, a polynucleotide sequence which encodes the factor, and antibodies which are immunoreactive with the factor. This factor... Read More
Inventors: Lee, Se-Jin; McPherron, Alexandra C.;, Assignee: Johns Hopkins University School of Medicine (Baltimore, MD) |
Method for using phagocytic particles and ATP receptors to deliver antigens to MHC class I receptors to induce immunity against microbial pathogens or tumors or to suppress immunity
OF THE INVENTION This invention provides a method of delivering an antigen to an Class I MHC receptor to induce immunity against the antigen in a subject having a disease which comprises: a) filling ... Read More
Inventors: Silverstein, Samuel C.; Loike, John D.; DiVirgilio, Francesco;, Assignee: The Trustees of Columbia University in the City of New York (New York, NY) |
Modulation of cholesteryl ester transfer protein (CETP) activity
The invention claimed is: 1. A method for treating or preventing atherosclerosis in a human or animal comprising administering to said human or animal an antigenic vaccine peptide comprising a univers... Read More
Inventors: Rittershaus, Charles W.; Thomas, Lawrence J.;, Assignee: Avant Immunotherapeutics, Inc. (Needham, MA) |
Nucleic acids, vectors and host cells encoding heregulin
In accordance with the objects of this invention, we have identified and isolated novel ligand families which bind to p185.sup.HER2. These ligands are denominated the heregulin (HRG) polypeptides, and... Read More
Inventors: Vandlen, Richard L.; Holmes, William E.;, Assignee: Genentech, Inc. (South San Francisco, CA) |
Immunoreactive peptides from Epstein-Barr virus
What is claimed is: 1. A polypeptide consisting of an amino acid sequence having the formula: (.phi.).sub.n wherein n is 1 to about 1000 and .phi. is 25 amino acids or less and has the formula: (.alph... Read More
Inventors: Smith, Richard S.; Pearson, Gary R.; Parks, D. Elliot; Varghese, Susan Pothen;, Assignee: Ortho Diagnostic Systems, Inc. (Raritan, NJ) Georgetown Univeristy (Washington, DC) |
DNA encoding stationary phase, stress response sigma factor from Mycobacterium tuberculosis
OF THE INVENTION It is a discovery of the present invention that entry of M. tuberculosis into a latent state is under the influence of an M. tuberculosis gene encoding a sigma factor, sigF. The expr... Read More
Inventors: Bishai, William R.; Young, Douglas B.; Zhang, Ying; DeMaio, James;, Assignee: The Johns Hopkins University (Baltimore, MD) |
Cyanovirin conjugates and matrix-anchored cyanovirin and related compositions and methods of use
The present invention provides, among other things, a method of removing virus from a sample. The method comprises contacting a sample with a composition comprising an isolated and purified antiviral ... Read More
Inventors: Boyd, Michael R;, Assignee: The United States of America as represented by the Department of Health and Human Services (Washington, DC) N/A ( |
.alpha.-.beta. C4BP-type recombinant heteromultimeric proteins
The object of the present invention is therefore to develop recombinant soluble heteromultimeric chimeric molecules which combine different functions in one and the same molecule, with a view to achie... Read More
Inventors: Klatzmann, David; Cohen, Jacques;, Assignee: Universite Pierre et Marie Curie (Paris VI) (Paris, FR) Universite de Reims Champagne-Ardennes (Reims, FR) |
Semi-refined carrageenan
The present invention provides methods for preparing a carrageenan product comprising the steps of providing a carrageenan-containing seaweed material having a seaweed solids content of less than 25% ... Read More
Inventors: Tsai, Albert G.; Ledwith, Linnea K.; Kopesky, Robert; Lynch, Maurice Gerard; Blakemore, William Ross; Riley, Peter J.;, Assignee: FMC Corporation (Philadelphia, PA) |
Method for improving genetic stability of foreign insert nucleotide sequence in recombinant poliovirus
To be free from shortcomings of the poliovirus vector systems, in particular, genetic instability of the foreign insert integrated into the recombinant polioviruses, the present inventors have examine... Read More
Inventors: Lee, Sang-Gu; Kim, Dae-You; Kim, Ki-Tae; Bae, Yong-Soo;, Assignee: CreaGene Inc. (KR) |
Dedifferentiated, programmable stem cells of monocytic origin, and their production and use
The invention relates to adult dedifferentiated programmable stem cells derived from human monocytes, as well as their production and use for the production of body cells and tissues. According to a ... Read More
Inventors: Kremer, Bernd Karl Friedrich; Fandrich, Fred; Ruhnke, Maren ne;, Assignee: Blasticon Biotechnologische Forschung GmbH (Keil, DE) |
Peptides which enhance transport across tissues and methods of identifying and using the same
The invention provides a method of identifying a peptide which permits or facilitates the transport of an active agent through a human or animal tissue. A predetermined amount of phage from a random p... Read More
Inventors: O'Mahony, Daniel Joseph;, Assignee: Elan Corporation, plc (Dublin, IE) |
Synthetic peptides and kits for diagnosis of anti-phospholipid syndrome
The invention claimed is: 1. A synthetic peptide selected from the group consisting: (i) a peptide of SEQ ID NO:1 to SEQ ID NO: 7, of the sequences: Leu-Lys-Thr-Pro-Arg-Val (SEQ ID NO:1); Lys-Thr-Pro-... Read More
Inventors: Blank, Miri; Cabilly, Shmuel; Shoenfeld, Yehuda; Katchalski-Katzir, Ephraim;, Assignee: Yeda Research Development Co., LTD (Rehovot, IL) |
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