Synthetic peptide inhibitors of HIV transmission
OF THE INVENTION 5.1 DP-178 AND DP-178-LIKE PEPTIDES 5.2 ASSAYS FOR ANTIVIRAL ACTIVITY 5.3 USES OF THE PEPTIDES OF THE INVENTION 6. EXAMPLE: DP-178 (SEQ ID:1) IS A POTENT INHIBITOR OF HIV-1 INFECTION... Read More
Inventors: Bolognesi, Dani P.; Matthews, Thomas J.; Wild, Carl T.;, Assignee: Duke University (Durham, NC) |
Compounds which inhibit HIV replication
A first aspect of the present invention is a peptide selected from the group consisting of: (a) the peptide DP-107, which has the formula, from amino terminus to carboxy terminus, of: NNLLRAIEAQQHLLQL... Read More
Inventors: Wild, Carl T.; Matthews, Thomas J.; Bolognesi, Dani P.;, Assignee: Duke University (Durham, NC) |
Hybrid polypeptides with enhanced pharmacokinetic properties
OF THE INVENTION Described herein are peptide sequences, referred to as enhancer peptide sequences, derived from various retroviral envelope (gp41) protein sequences that are capable of enhancing the... Read More
Inventors: Barney, Shawn; Guthrie, Kelly I.; Merutka, Gene; Anwer, Mohmed K.; Lambert, Dennis M.;, Assignee: Trimeris, Inc. (Durham, NC) |
1-aryl-2-hydroxyethyl amides as potassium channel openers
OF THE INVENTION The present invention provides novel aryl hydroxyethyl amides and related derivatives which are modulators of the KCNQ potassium channels and which have the general Formula I or a ph... Read More
Inventors: Wu, Yong-Jin; Sun, Li-Qiang; He, Huan; L'Heureux, Alexandre;, Assignee: Bristol-Myers Squibb Company (Princeton, NJ) |
Method of eliciting anti-HIV-1 helper T cell responses
A number of HIV-1 p24 peptides that elicit HIV-1-specific helper T cell responses have been identified. Contemplated within the scope of this invention are methods of administering p24 peptides, vect... Read More
Inventors: Walker, Bruce D.;, Assignee: The General Hospital Corporation (Boston, MA) |
pDJA1, a cardiac specific gene, corresponding proteins, and uses thereof
OF THE INVENTION Before the present methods and treatment methodology are described, it is to be understood that this invention is not limited to particular methods, and experimental conditions descr... Read More
Inventors: Depre, Christophe; Vatner, Stephen F.;, Assignee: Univ. of Medicine & Dentistry of N.J. (New Brunswick, NJ) |
GPIb.alpha. fragments and recombinant DNA expression vectors
As set forth in aforementioned application Ser. No. 07/470,674, there are provided peptides comprising any peptide of the 45 kDa amino terminal tryptic fragment of glycocalicin selected from the amino... Read More
Inventors: Ruggeri, Zaverio M.; Ware, Jerry L.;, Assignee: The Scripps Research Institute (La Jolla, CA) |
Expression vector encoding hybrid immunoglobulins
Ligand binding partners as defined herein are proteins known to function to bind specifically to target ligand molecules, and are generally found in their native state as secreted or membrane bound p... Read More
Inventors: Capon, Daniel J.; Lasky, Laurence A.;, Assignee: Genentech, Inc. (San Francisco, CA) |
Hybrid immunoglobulins
Ligand binding partners as defined herein are proteins known to function to bind specifically to target ligand molecules, and are generally found in their native state as secreted or membrane bound p... Read More
Inventors: Capon, Daniel J.; Lasky, Laurence A.;, Assignee: Genentech Inc. (South San Francisco, CA) |
GPIb-lipid complex and uses thereof
What is claimed is: 1. A complex comprising a lipid and a conjugate of GPIb or a GPIB fragment having a von Willebrand factor-binding capability that is almost at the same level as GPIb itself and a l... Read More
Inventors: Matsuda, Hiroshi; Kamide, Kaeko; Amatsuji, Yasuo; Imagawa, Takashi; Ikeda, Yasuo; Murata, Mitsuru;, Assignee: Yoshitomi Pharmaceutical Industries, Ltd. (Osaka, JP) |
Immuno-modulating antitumor activities of Ganoderma lucidum (Reishi) polysaccharides
We claim: 1. A composition comprising one or more fractions, the one or more fractions obtainable by a process comprising: homogenizing tissue of Ganoderma lucidum; extracting the homogenized tissue w... Read More
Inventors: Wang, Yuan-Yuan; Khoo, Kay-Hooi; Chen, Shui-Tein; Lin, Chun-Cheng; Wong, Chi-Huey; Lin, Chun-Hung; Chen, Hong-Sen; Tsai, Yow-Fu;, Assignee: Academia Sinica (TW) |
Administration of "active" chondroitin sulfate A and "active" chondroitin sulfate C or mixtures thereof to mammals including humans
I claim: 1. The method which comprises the administration of "active" chondroitin sulfate A (CSA), "active" chondroitin sulfate C (CSC), or mixtures thereof to mammals including humans to the surfaces... Read More
Inventors: Hausman, Marvin S.;, Assignee: |
Painless electrolyte solutions
What is claimed is: 1. A composition consisting of: (a) electrolytes selected from the group consisting of K.sup.+, Ca.sup.++, Na.sup.+ and Mg.sup.++ salts of anions, wherein said K.sup.+ is present a... Read More
Inventors: Hustead, Robert E.; Hustead, David R.;, Assignee: |
Method for enhancing healing of corneal endothelial wounds
Method using a non-steroidal antiinflammatory compound, such as indomethacin, and/or a growth factor that causes a change in cell function when bound to a cell surface receptor, such as epidermal grow... Read More
Inventors: Neufeld, Arthur H.; Joyce, Nancy C.; Jumblatt, Marcia M.;, Assignee: Eye Research Institute of Retina Foundation, Inc. (Boston, MA) |
Method and agents for promoting wound healing
In accordance with the present invention, diagnostic and therapeutic protocols are proposed that are predicated in part on the discovery that certain cytokines have been determined to possess a defini... Read More
Inventors: Fahey, III, Thomas J.; Sherry, Barbara A.; Cerami, Anthony;, Assignee: The Rockefeller University (New York, NY) |
Control of post-surgical intraocular pressure using clonidine derivatives
OF THE INVENTION The present invention utilizes certain clonidine derivatives, as defined above, to control intraocular pressure of the eye during invasive or non-invasive ophthalmic surgery. Clonidi... Read More
Inventors: House, Betty R.; DeFaller, Joseph M.; York, Billie M.;, Assignee: Alcon Laboratories, Inc. (Fort Worth, TX) |
Tissue irrigating solution
OF THE PREFERRED EMBODIMENTS The present invention is directed generally to an improved technique for packaging a tissue irrigating solution of the type which includes glutathione/bicarbonate/Ringer ... Read More
Inventors: Newton, Walter A.;, Assignee: Entravision, Inc. (Lenoir, NC) |
Indolyl substituted hydroxylamine derivatives
OF THE INVENTION More particularly the invention relates to the compounds of formula I ##STR2## wherein R represents hydrogen, lower alkyl, aryl, biaryl, C.sub.3 -C.sub.7 -cycloalkyl, aryl-lower alky... Read More
Inventors: Van Duzer, John H.; Roland, Dennis M.;, Assignee: Ciba-Geigy Corporation (Ardsley, NY) |
Prevention of synovial adhesions
OF THE INVENTION A wide variety of lipid particles may include a nonsteroidal antiinflammatory agent to form the vesicles of the invention, which are capable of preventing the formation of adhesions ... Read More
Inventors: Moore, Larry J.; Adler-Moore, Jill;, Assignee: Vestar, Inc. (San Dimas, CA) |
Method for reducing unwanted cellular adhesions
In accordance with one aspect of the present invention there is provided a method for reducing undesired cell adhesions at a compromised site. The method involves treating the compromised site with a ... Read More
Inventors: Baker, Margaret A.; Ohlsson-Wilhelm, Betsy M.;, Assignee: Zynaxis, Inc. (Malvern, PA) |
Anti-infective and anti-inflammatory releasing systems for medical devices
Devices are provided having a polymer coating incorporating compounds inhibiting inflammation and infection, along with subsequent tissue growth onto and around the device. Preferred embodiments inclu... Read More
Inventors: Domb, Abraham J.; Shikani, Alain; Haffer, Andrew S. T.; Maniar, Manoj;, Assignee: Bloom; Leonard (Towson, MD) |
Combined use of dopamine and serotonin agonists in the treatment of immune disorders
What is claimed is: 1. A method of treating a disorder to the immune system selected from the group consisting of fibromyalgia and chronic fatigue syndrome comprising administering to a patient in nee... Read More
Inventors: Hitzig, Pietr;, Assignee: |
Combinational therapeutic methods employing nitric oxide scavengers and compositions useful therefor
OF THE INVENTION In accordance with the present invention, there are provided combinational therapeutic methods for directly or indirectly treating the production of species which induce the expressi... Read More
Inventors: Lai, Ching-San;, Assignee: Medinox, Inc. (San Diego, CA) |
Use of interleukin-4 receptors to inhibit biological responses mediated by interleukin-4
The present invention provides DNA sequences encoding mammalian Interleukin-4 receptors (IL-4R) or subunits thereof. Preferably, such DNA sequences are selected from the group consisting of: (a) cDNA ... Read More
Inventors: Mosley, Bruce; Cosman, David J.; Park, Linda; Beckmann, M. Patricia; March, Carl J.; Idzerda, Rejean;, Assignee: Immunex Corporation (Seattle, WA) |
Surgical irrigation solution and method for inhibition of pain and inflammation
The present invention provides a solution constituting a mixture of multiple agents in low concentrations directed at inhibiting locally the mediators of pain, inflammation, spasm and restenosis in a ... Read More
Inventors: Demopulos, Gregory A.; Pierce, Pamela A.; Herz, Jeffrey M.;, Assignee: Omeros Medical Systems, Inc. (Seattle, WA) |
Method of treatment of osteoarthritis with interleuken-1 receptor antagonist
OF THE INVENTION As indicated hereinabove, the present invention is directed to both a method and a composition for the treatment of osteoarthritis in a mammal and more especially in a human being, b... Read More
Inventors: Pelletier, Jean-Pierre; Martel-Pelletier, Johanne;, Assignee: Arthro Lab Inc. (Sherbrooke, CA) |
Viral vectors to inhibit leukocyte infiltration or cartilage degradation of joints
The present invention has met the above described needs by providing methods for introducing at least one gene encoding a product into at least one cell of a mammalian host for use in treating the mam... Read More
Inventors: Glorioso, Joseph C.; Evans, Christopher H.; Robbins, Paul D.; Ghivizzani, Steven C.;, Assignee: University of Pittsburgh of the Commonwealth System of Higher Education (Pittsburgh, PA) |
Surgical irrigation solution and method for inhibition of pain and inflammation
The present invention provides a solution constituting a mixture of multiple agents in low concentrations directed at inhibiting locally the mediators of pain, inflammation, spasm and restenosis in a ... Read More
Inventors: Demopulos, Gregory A.; Pierce, Pamela A.; Herz, Jeffrey M.;, Assignee: Omeros Medical Systems, Inc. (Seattle, WA) |
Surgical irrigation solution and method for inhibition of pain and inflammation
The present invention provides a solution constituting a mixture of multiple agents in low concentrations directed at inhibiting locally the mediators of pain, inflammation, spasm and restenosis in a ... Read More
Inventors: Demopulos, Gregory A.; Pierce, Pamela A.; Herz, Jeffrey M.;, Assignee: Omeros Medical Systems, Inc. (Seattle, WA) |
Hyaluronic acid and chondroitin sulfate based hydrolyzed collagen type II and method of making same
One embodiment of the present invention is hydrolyzed collagen type II, the hydrolyzed collagen having an average molecular weight of between about 50 and 10,000 daltons. Preferably, the hydrolyzed co... Read More
Inventors: Ishaq, Suhail;, Assignee: Intellipi, LLC (Anaheim, CA) |
Drugs 
