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| Latest patents |
Results: 181-210 of 3116
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Method and compositions for identification of species in a sample using type II topoisomerase sequences
The invention comprises means to identify one or more species in a sample by selectively amplifying a nucleic acid segment encoding a signature region of a macromolecule which is present in all the or... Read More
Inventors: Huang, Wai Mun;, Assignee: University of Utah Research Foundation (Salt Lake City, UT) |
Oxygen carrier system, artificial oxygen carrier, and reducing agent
OF THE INVENTION The present invention will be explained in detail below. The oxygen carrier system of the present invention comprises an artificial oxygen carrier containing a given hemoglobin vesic... Read More
Inventors: Tsuchida, Eishun; Takeoka, Shinji; Teramura, Yuji; Atoji, Tomoyasu;, Assignee: Oxygenix Co., Ltd (Tokyo, JP) |
Composition for feeding prey organisms in aquaculture
OF INVENTION The composition according to the invention, for feeding prey organisms comprises as its main component a phospholipid-rich component. In the present context, the expression `prey organis... Read More
Inventors: Hjaltason, Baldur; Haraldsson, Gudmundur G.; Halldorsson, Olafur;, Assignee: |
2-halo-2'-deoxyadenosines in the treatment of rheumatoid arthritis
OF THE INVENTION The present invention contemplates a compound, a composition containing that compound and a method of using a composition of the invention, or another composition, for treating a mon... Read More
Inventors: Carson, Dennis A.; Carrera, Carlos J.;, Assignee: The Scripps Research Institute (La Jolla, CA) |
Method and composition for an early vaccine to protect against both common infectious diseases and chronic immune mediated disorders or their sequelae
The present invention may be used to overcome one or more deficiencies of the related art. It relates to the discovery that a supplemental childhood immunization schedule of immunization with a pediat... Read More
Inventors: Classen, John Barthelow;, Assignee: Classen Immunotherapies, Inc. (Baltimore, MD) |
Two new human DNAJ-like proteins
What is claimed is: 1. An isolated and purified polynucleotide sequence encoding the amino acid sequence of SEQ ID NO:1. 2. A composition comprising the polynucleotide sequence of claim 1. 3. A polynu... Read More
Inventors: Au-Young, Janice; Lal, Preeti; Bandman, Olga;, Assignee: Incyte Pharmaceuticals, Inc. (Palo Alto, CA) |
Method and compositions for the treatment of autoimmune disease using heat shock proteins
OF THE INVENTION Methods and compositions for the treatment of autoimmune disease are described. The invention is based, in part, on newly discovered treatment regimens which provide protection again... Read More
Inventors: Srivastava, Pramod K.; Chandawarkar, Rajiv Y.;, Assignee: Fordham University (Bronx, NY) |
Recombinant antibody and antibody fragment
OF THE INVENTION This application is based on Japanese applications No. 2000-59508 filed on Mar. 3, 2000 and No. 2000-401563 filed on Dec. 28, 2000, the entire contents of which are incorporated here... Read More
Inventors: Shitara, Kenya; Hanai, Nobuo; Shoji, Emi; Sakurada, Mikiko; Furuya, Akiko; Nakamura, Kazuyasu; Niwa, Rinpei; Shibata, Kenji; Yamasaki, Motoo;, Assignee: Kyowa Hakko Kogyo Co., Ltd. (Tokyo, JP) |
Pneumococcal surface protein C (PspC), epitopic regions and strain selection thereof, and uses therefor
PspC (see FIGS. 1, 2, 3, 4, 5, 11, 12, 13, 14, 15) is one of three designations for a pneumococcal surface protein which is PspA-like, and whose gene is present in approximately 75% of all S. pneumon... Read More
Inventors: Briles, David E.; Hollingshead, Susan K.; Brooks-Walter, Alexis;, Assignee: UAB Research Foundation (Birmingham, AL) |
Large DNA cloning system based on yeast artificial chromosomes
OF THE INVENTION While the specification concludes with claims particularly pointing out and distinctly claiming the subject matter regarded as forming the present invention, it is believed that the ... Read More
Inventors: Olson, Maynard V.; Burke, David T.;, Assignee: Washington University (St. Louis, MO) |
Rat neurotrophic factor receptor, GFRα-4
OF THE INVENTION Thus, the present invention relates to a nucleic acid molecule encoding a mammalian GDNF family receptor α-4 (GFRα-4) or an immunologically and/or biologically active fra... Read More
Inventors: Masure, Stefan L. J.; Cik, Miroslav; Hoefnagel, Evert W.;, Assignee: Janssen Pharmaceutica N.V. (Beerse, BE) |
Polypeptide and protein derivatives and process for their preparation
What we claim is: 1. A method of producing a composition containing modified protein or polypeptide molecules, or salts thereof, wherein said modified protein or polypeptide molecules of said composit... Read More
Inventors: Offord, Robin Ewart; Rose, Keith;, Assignee: Amylin Pharmaceuticals, Inc. (San Diego, CA) |
Single chain MHC complexes and uses thereof
The present invention relates to novel complexes of major histocompability complex (MHC) molecules (class I or II), e.g., empty single chain MHC class II complexes, loaded single chain MHC class II co... Read More
Inventors: Rhode, Peter R.; Jiao, Jin-An; Burkhardt, Martin; Wong, Hing C.;, Assignee: Sunol Molecular Corporation (Miami, FL) |
IL-1/TNF-.alpha.-activated kinase (ITAK), and methods of making and using the same
The present invention provides nucleic acid and amino acid sequences of protein kinases, preferably human, that interact with at least one post-receptor intracellular pathway of both IL-1 and TNF-.alp... Read More
Inventors: Sims, John E.; Virca, G. Duke; Bird, Timothy A.; Anderson, Dirk M.;, Assignee: Immunex Corporation (Seattle, WA) |
DNA encoding IL-1 receptor accessory protein
What is claimed is: 1. An isolated polynucleotide comprising SEQ ID NO:1 wherein the nucleic acid at 1792 is A or C. 2. An isolated polynucleotide comprising a nucleic acid that encodes a polypeptide... Read More
Inventors: Sims, John E.; Smith, Dirk E.;, Assignee: Immunex Corporation (Thousand Oaks, CA) |
Human immunodeficiency virus immunogenic composition
The present invention relates to an HLA-based vaccine against HIV. Vaccines of the invention, which induce salutary anti-HIV immune responses, can be designed based on analysis of the HLA alleles pres... Read More
Inventors: Haynes, Barton F.; Liao, Hua-Xin; Letvin, Norman;, Assignee: Duke University (Durham, NC); Beth Israel Deaconess Medical Center (Boston, MA) |
Recombinant molecule encoding human protease nexin
We claim: 1. An isolated DNA molecule which encodes mature protease nexin-I (PN-I) alpha of FIG. 3 or PN-I beta of FIG. 4 or encodes a PN-I protein encoded by a gene which is a naturally occurring all... Read More
Inventors: Baker, Joffre B.; Scott, Randy W.;, Assignee: Incyte Pharmaceuticals, Inc. (Redwood City, CA) |
Method for design of substances that enhance memory and improve the quality of life
I claim: 1. Each of the compounds Gln Phe Phe-.gamma.-aminobutyric acid (SEQ ID NO: 20) Gln Phe Phe-.beta.-alanine (SEQ ID NO: 21) Gln Phe Phe-.delta.-aminovaleric acid (SEQ ID NO:22) Lys Phe Phe Gly ... Read More
Inventors: Roberts, Eugene;, Assignee: City of Hope (Duarte, CA) |
Amyloid .beta. protein (globular assembly and uses thereof)
What is claimed is: 1. An isolated, soluble, non-fibrillar amyloid .beta. protein assembly comprising 3-12 amyloid .beta. proteins, wherein the amyloid .beta. protein is the .beta.1-42 protein and whe... Read More
Inventors: Krafft, Grant A.; Klein, William L.; Chromy, Brett A.; Lambert, Mary P.; Finch, Caleb E.; Morgan, Todd; Wals, Pat; Rozovsky, Irina; Barlow, Ann;, Assignee: Northwestern University (Evanston, IL); University of Southern California (Los Angeles, CA) |
Chlamydia antigens and corresponding DNA fragments and uses thereof
The present invention provides purified and isolated polynucleotide molecules that encode the Chlamydia polypeptide designated 76 kDa protein (SEQ ID No: 1) which can be used in methods to prevent, tr... Read More
Inventors: Murdin, Andrew D.; Oomen, Raymond P.; Wang, Joe; Dunn, Pamela;, Assignee: Sanofi Pasteur Limited (Toronto, CA) |
Methods of treating inflammatory bowel disease using cholera toxin B subunit
What is claimed is: 1. A method of treating inflammatory bowel disease in a subject diagnosed with inflammatory bowel disease, comprising administering to the subject a therapeutically effective amoun... Read More
Inventors: Stober, Warren; Fuss, Ivan J.; Kelsall, Brian L.; Boirivant, Monica;, Assignee: The United States of America as represented by the Department of Health and Human Services (Washington, DC) |
Mammalian haemoglobin compatible with blood plasma, cross-linked and conjugated with polyalkylene oxides as artificial medical oxygen carriers, production and use thereof
1. Hemoglobin derivative compatible with human and non-human animal plasma, comprising hemoglobin crosslinked by means of a crosslinker for proteins and a polyalkylene oxide covalently linked to the h... Read More
Inventors: Barnikol, Wolfgang;, Assignee: Sanguibiotech GmbH (Witten, DE) |
Anti hepatitis C virus antibody and uses thereof
OF THE PRESENT INVENTION Accordingly, the technical problem of the invention is to provide means and methods for the treatment and prevention of HCV infection in humans. The solution to this technica... Read More
Inventors: Reiter, Christian; Habersetzer, Francois; Fournillier, Anne; Trepo, Christian; Desgranges, Claude; Inchauspe, Genevieve;, Assignee: Genmab A/S (Copenhagen K, DK); Institut National de la Sante et de la Recherche Medicale (I.N.S.E.R.M.) (Paris, FR) |
Chemical and/or biological decontamination system
OF THE INVENTION The present invention provides a composition that is effective in the decontamination of chemical agents and/or biological pathogens. The biological pathogen decontaminant compositio... Read More
Inventors: Conerly, Lisa L.; Ehntholt, Daniel J.; Louie, Alan S.; Whelan, Richard H.;, Assignee: Tiax LLC (Cambridge, MA) |
Immunostimulant bacterial membrane fractions in cancer treatment
The invention claimed is: 1. A method of stimulating an immune response and/or inducing an antitumor immune response in a mammal, including a human, in need thereof, characterized by stimulation of pr... Read More
Inventors: Libon, Christine; Corvaia, Nathalie; Beck, Alain; Bonnefoy, Jean-Yves;, Assignee: Pierre Fabre Medicament (Boulogne-Billancourt, FR) |
Cloning and characterization of a human adenylyl cyclase
One aspect of the invention is an isolated and purified human type VI adenylyl cyclase (hAC6) polypeptide comprising the amino acid sequence of FIG. 1 (SEQ ID NO:2). Another aspect of the invention is... Read More
Inventors: Tomlinson, James E.;, Assignee: Bayer Healthcare AG (Leverkusen, DE) |
Tumor antigen based on products of the tumor suppressor gene WT1
What is claimed is: 1. An isolated polypeptide which consists of at most 12 contiguous amino acid residues of a human WT1 protein, wherein the polypeptide comprises SEQ ID NO: 5, binds to MHC proteins... Read More
Inventors: Sugiyama, Haruo; Oka, Yoshihiro;, Assignee: Haruo Sugiyama (Mino, JP) |
Methods of inhibiting GPR-9-6 function
The invention relates to an antibody (immunoglobulin) or functional fragment thereof (e.g., an antigen-binding fragment) which binds to a mammalian GPR-9-6 (GPR-9-6 is also referred to as CC chemokine... Read More
Inventors: Andrew, David P.; Zabel, Brain A.; Ponath, Paul D.;, Assignee: Millennium Pharmaceuticals, Inc. (Cambridge, MA) |
Method for cloning of a rare, specifically mutated cell
The invention is a new and improved method for reliably detecting the presence of a rare cell having a desired nucleotide mutation that was introduced by a sequence-specific process. According to the ... Read More
Inventors: Metz, Richard; DiCola, Mike; Blaese, R. Michael;, Assignee: PreGentis (New Town, PA) |
Vaccine against Gram-negative bacterial infections
OF THE PREFERRED EMBODIMENTS According to the present invention, a non-covalent, polyvalent complex between purified, detoxified LPS ("DLPS") derived from E. coli and purified outer membrane protein ... Read More
Inventors: Bhattacharjee, Apurba; Cross, Alan; Sadoff, Jerald; Zollinger, Wendell;, Assignee: United States of America as represented by the Secretary of the Army (Washington, DC) |
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