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Results: 211-240 of 3116
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Modified human hemoglobin, blood substitutes containing the same, and vectors for expressing the modified hemoglobin
The present invention relates to modified .beta.-chains of human hemoglobin having an oxygen binding affinity equal to or less than natural human hemoglobin. Preferably, the oxygen binding affinity P.... Read More
Inventors: Fronticelli, Clara; Bucci, Enrico; Brinigar, William;, Assignee: Research Corporation Technologies, Inc. (Tucson, AZ) |
Inhibitor of stem cell proliferation and uses thereof
The present invention relates to polypeptides which are inhibitors of stem cell proliferation ("INPROL") and their use. The present invention includes an inhibitor of stem cell proliferation character... Read More
Inventors: Wolpe, Stephen D.;, Assignee: Pro-Neuron, Inc. (Rockville, MD) |
Inhibitor of stem cell proliferation and uses thereof
The present invention relates to an inhibitor of stem cell proliferation (INPROL) characterized by the following properties: (a) Specific activity (IC.sub.50) less than or equal to 20 ng/ml in a murin... Read More
Inventors: Kozlov, Vladimir; Tsyrlova, Irena;, Assignee: Pro-Neuron, Inc. (Rockville, MD) |
Method of inhibiting angiogenesis using secreted proteins
Isolated Proteins Nucleotide and amino acid sequences, as presently determined, are reported below for each clone and protein disclosed in the present application. The nucleotide sequence of each clo... Read More
Inventors: Jacobs, Kenneth; McCoy, John M.; Racie, Lisa A.; LaVallie, Edward R.; Merberg, David; Treacy, Maurice; Evans, Cheryl;, Assignee: Genetics Institute, Inc. (Cambridge, MA) |
Balanced extraction system
The present invention is a device wherein matter to be extracted which contains various available components is kept in a state almost like a natural environment or, for example, enclosed within a dec... Read More
Inventors: Kuoyama, Nobuyoshi;, Assignee: |
Compounds for the treatment of hepatoma
What is claimed is: 1. The method of treatment of a living subject affected by hepatoma which consists of administering to said subject by the oral route up to three times daily a pharmaceutical compo... Read More
Inventors: Lin, Chun-Nan; Won, Shen-Jeu; Lieu, Hsiao-Sheng; Liou, Shorong-Shii;, Assignee: National Science Council (Taipei, TW) |
5ht2 agonists for controlling IOP and treating glaucoma
1. A method for lowering or controlling intraocular pressure or treating glaucoma which comprises administering a composition comprising a pharmaceutically effective amount of 1-(2-aminopropyl)-indazo... Read More
Inventors: May, Jesse A.; Dantanarayana, Anura P.;, Assignee: Alcon, Inc. (Hunenberg, CH); Yamanouchi Pharmaceutical Co., Ltd. (Tokyo, JP) |
Insect resistant tomato and potato plants
We claim: 1. A chimeric gene capable of expressing in a plant cell comprising in sequence: (a) a promoter which functions in plants to cause the production of RNA; (b) a DNA sequence that causes the p... Read More
Inventors: Fischhoff, David A.; Fuchs, Roy L.; Lavrik, Paul B.; McPherson, Sylvia A.; Perlak, Frederick J.;, Assignee: Monsanto Company (St. Louis, MO) |
Insect resistant plants
In accordance with one aspect of the present invention, there has been provided a method for producing genetically transformed plants which exhibit toxicity toward Coleopteran insects, comprising the ... Read More
Inventors: Fischhoff, David A.; Fuchs, Roy L.; Lavrik, Paul B.; McPherson, Sylvia A.; Perlak, Frederick J.;, Assignee: Monsanto Company (St. Louis, MO) |
Hybrid toxin
What is claimed is: 1. An insecticidal Bacillus thuringiensis hybrid toxin fragment, comprising: a) at a C-terminus of said fragment, domain m of III first Cry protein; and b) at an N-terminus of said... Read More
Inventors: Bosch, Hendrik Jan; Stiekema, Willem Johannes;, Assignee: Novartis AG (Basel, CH) |
Antigenic proteins of Borrelia burgdorferi
It is an object of the present invention to provide a means for detecting mammals previously or presently infected with Lyme disease. In one embodiment, the present invention relates to substantially ... Read More
Inventors: Simpson, Warren; Schwan, T. G.;, Assignee: |
Osp A and B Sequence of Borrelia burgdonferi strains ACA1 and IP90
We claim: 1. An isolated DNA molecule consisting of a nucleotide sequence as shown in FIG. 3 for ACA1 (SEQ ID NO: 5), or a sequence exactly complementary thereto. 2. An isolated DNA molecule consistin... Read More
Inventors: Barbour, Alan George; Bergstrom, Sven; Hansson, Lennart;, Assignee: Symbicom Aktiebolag (Umea, SE) |
Compositions and methods using the borreliacidal epitope(s) of borrelia burgdorferi outer surface protein C (OspC) for the diagnosis and prevention of lyme disease
The present invention is directed to an isolated, immunogenic polypeptide fragment of OspC of Borrelia burgdorferi consisting essentially of an epitope of OspC having an amino acid sequence as shown i... Read More
Inventors: Callister, Steven M.; Lovrich, Steven D.; Schell, Ronald F.; Jobe, Dean A.;, Assignee: Gundersen Lutheran Medical Foundation (La Crosse, WI) |
Isolation and use of solid tumor stem cells
The invention claimed is: 1. A method for determining the capability of a test compound to inhibit tumorigenesis of solid tumor stem cells of epithelial origin, said method comprising: a) obtaining en... Read More
Inventors: Clarke, Michael F.; Morrison, Sean J.; Wicha, Max S.; al-Hajj, Muhammad;, Assignee: Regents of the University of Michigan (Ann Arbor, MI) |
Hair analysis method
OF THE INVENTION In accordance with the present invention, a method is provided that permits the rapid and complete solubilization of a certain analyte from head or body hair or other keratinized str... Read More
Inventors: Baumgartner, Werner Andreas;, Assignee: Psychemical Corporation (Action, MA) |
Method for retarding or precluding Alzheimer's dementia
OF THE INVENTION The markers which are targeted according to the method of the invention are those which are released into the circulation as a consequence of disease state and may be present in the ... Read More
Inventors: Jackowski, George; Furesz, Shirley;, Assignee: Syn X Pharma, Inc. (Ontario, CA) |
Streptococcus pneumoniae polynucleotides and sequences
OF ILLUSTRATIVE EMBODIMENTS The present invention is based on the sequencing of fragments of the Streptococcus pneumoniae genome and analysis of the sequences. The primary nucleotide sequences genera... Read More
Inventors: Kunsch, Charles A.; Choi, Gil H.; Dillon, Patrick S.; Rosen, Craig A.; Barash, Steven C.; Fannon, Michael R.; Dougherty, Brian A.;, Assignee: Human Genome Sciences, Inc. (Rockville, MD) |
Protection against dental caries
I claim: 1. A process for producing an antigen preparation, for use in the reduction or prevention of dental caries, from bacteria of the group Streptococcus mutans genetic group I, the preparation be... Read More
Inventors: Russell, Roy R. B.;, Assignee: The Secretary of State of Social Services in Her Britannic Majesty's (London, GB2) |
High molecular weight polymer-based prodrugs
In one aspect of the invention, compositions of formula (I) are provided: ##STR2## wherein: D is a biologically active moiety; X is an electron withdrawing group; Y and Y' are independently O or S; R.... Read More
Inventors: Greenwald, Richard B.; Pendri, Annapurna;, Assignee: Enzon, Inc. (Piscataway, NJ) |
Macrocyclic NS-3 serine protease inhibitors of hepatitis C virus comprising alkyl and aryl alanine P2 moieties
OF PREFERRED EMBODIMENTS In one embodiment, the present invention discloses compounds of Formula I as inhibitors of HCV protease, especially the HCV NS3/NS4a serine protease: ##STR7## where the vari... Read More
Inventors: Venkatraman, Srikanth; Chen, Kevin X.; Arasappan, Ashok; Njoroge, F. George; Girijavallabhan, Viyyoor Moopil; Ganguly, Ashit K.; Chan, Tin-Yau; Mc Kittrick, Brian Alexander; Yao, Nanhua Hugh; Prongay, Andrew Joseph; Madison, Vincent Stewart;, Assignee: Schering Corporation (Kenilworth, NJ) |
Hyphal growth in fungi
The present invention is based, in part, upon the discovery of Aspergillus genes that are associated with fungal morphology and in particular with hyphal branching. A linear relationship between the d... Read More
Inventors: Dunn-Coleman, Nigel; Turner, Geoffrey; Pollerman, Sarah E.; Memmott, Stephen D.;, Assignee: Genencor International, Inc. (Palo Alto, CA); University of Sheffield (Sheffield, GB) |
Peptides for use in immunotherapy of autoimmune diseases
1. An isolated peptide of 9-55 amino acids comprising the amino acid sequence FTLASAETT (SEQ ID NO: 1). 2. An isolated peptide of 13-55 amino acids comprising the amino acid sequence HSFTLASAETTVG (SE... Read More
Inventors: Verheijden, Gijsbertus Franciscus Maria; Boots, Anna Maria Helena;, Assignee: Akzo Nobel N.V. (Arnhem, NL) |
PCR assay
Accordingly, one object of the present invention is to provide a quantitative method for detecting the presence and/or the amount of a target compound in a sample where the method has equal or improve... Read More
Inventors: Dodge, Anthony H.; Meng, Yu-Ju G.; Sims, Paul W.; Sinicropi, Dominick V.; Williams, P. Mickey; Wong, Wai Lee;, Assignee: Genentech, Inc. (South San Francisco, CA) |
Streptococcus pneumoniae capsular polysaccharide genes and flanking regions
OF THE PREFERRED EMBODIMENTS The present inventors have determined a genetic and physical map that encompasses the region responsible for the synthesis of the polysaccharide capsule of S. pneumoniae.... Read More
Inventors: Yother, Janet; Dillard, Joseph;, Assignee: UAB Research Foundation (Birmingham, AL) |
Process for the simultaneous production of xylitol and ethanol
An improved method is provided to produce ethanol, as well as perhaps other important products, such as xylitol, from lignocellulose-containing material in biomass. Advantageously, the method is effec... Read More
Inventors: Eroma, Olli-Pekka; Heikkila, Heikki; Ojamo, Heikki; Sarmala, Pa; Hyoky, Go; Rahkila, Leena; Sarkki, Marja-Leena; Viljava, Tapio;, Assignee: Danisco Sweeteners Oy (Espoo, FI) |
Ichimeric papillomavirus-like particles
OF THE INVENTION This invention arises from the result that a papillomavirus L2 fusion product can become incorporated into a papillomavirus L1 product-based papillomavirus-like particle that present... Read More
Inventors: Lowy, Douglas R.; Schiller, John T.; Greenstone, Heather;, Assignee: The United States of America as represented by the Department of Health (Washington, DC) |
Leporipox-based vector vaccines
1. A method of treating a non-lepori species against contracting an infectious disease, comprising: administering a live, recombinant leporipox virus comprising exogenous DNA, which is operably linked... Read More
Inventors: Spibey, Norman;, Assignee: Akzo Nobel N.V. (Arnhem, NL) |
Peptides for neutralizing the toxicity of Lipid A
OF THE INVENTION The applicant has discovered what is being characterized as the minimal peptide structure which will bind endotoxin. These structures are comprehended by peptides having units of the... Read More
Inventors: Porro, Massimo;, Assignee: BiosYnth S.r.l. (Siena, IT) |
Polymyxin B conjugates
What is claimed is: 1. A method, comprising: a) providing: i) polymyxin B comprising a diaminobutyric acid residue, said residue having a gamma amino group, ii) an amino acid selected from the group c... Read More
Inventors: Shekhani, Mohammed Saleh; Schatz, Robert W.; Pugh, Charles; Panasik, Jr., Nicholas; Stafford, Douglas;, Assignee: Promega Corporation (Madison, WI) |
Pigment dispersion and related method of manufacture
OF THE INVENTION The present invention is generally formed by mixing water or an aqueous base with an oil dispersion or oil mixture that contains pigments. The mixed aqueous base and oil mixture are ... Read More
Inventors: Qu, Di; Leverett, Jesse C.;, Assignee: Access Business Group International LLC (Ada, MI) |
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