Recovering purified antibodies from egg yolk
What is claimed is: 1. A process for recovering purified IgY antibodies from fowl egg yolk containing said antibodies, comprising the steps of (a) rendering the lipid content and the caseinous protein... Read More
Inventors: Polson, Alfred;, Assignee: The South African Inventions Development Corporation (Pretoris, ZA) |
Analogs of viscosin and their uses
OF THE INVENTION Viscosin is a peptide lactone composed of alternating D and L amino acids with a .beta.-D-hydroxydecanoyl dipeptide side chain. This peptide has antibacterial, antiviral and antitryp... Read More
Inventors: Burke, Jr., Terrence; Chandrasekhar, Bhaskar; Knight, Martha;, Assignee: Peptide Technologies Corporation (Washington, DC) |
Single polypeptide chain binding molecules
The present invention starts with a computer based system and method to determine chemical structures for converting two naturally aggregated but chemically separated light and heavy polypeptide chain... Read More
Inventors: Ladner, Robert C.; Bird, Robert E.; Hardman, Karl;, Assignee: Enzon, Inc. (South Plainfield, NJ) |
Bcl-2 and R-ras complex
Generally, the nomenclature used hereafter and the laboratory procedures in cell culture, molecular genetics, and nucleic acid chemistry and hybridization described below are those well known and com... Read More
Inventors: Bischoff, James R.; Fernandez-Sarabia, Maria J.;, Assignee: Onyx Pharmaceuticals, Inc. (Richmond, CA) |
Heterodimeric receptor libraries using phagemids
A new surface-integration technology has been discovered for expressing a heterodimeric recombinant gene product on the surface of a filamentous phage containing the recombinant gene. The invention us... Read More
Inventors: Barbas, Carlos; Kang, Angray; Lerner, Richard A.;, Assignee: The Scripps Research Institute (La Jolla, CA) |
Method for producing highly reactive polyisobutenes
We claim: 1. A process for the preparation of highly reactive polyisobutenes, in which a) isobutene is polymerized in the presence of a complex of boron trifluoride and at least one cocatalyst in a li... Read More
Inventors: Auer, Heinz; Kanne, Ulrich; De Vos, Andre;, Assignee: BASF Aktiengesellschaft (Ludwigshafen, DE) |
Device and mixture for testing for immune responses to food
In accordance with the present invention the aforementioned needs are fulfilled by providing an inexpensive, simple and quick test for detecting an individual's Type I, II, III and IV Gell-Coombs immu... Read More
Inventors: Breneman, James C.;, Assignee: |
Compounds for immunotherapy of prostate cancer and methods for their use
OF THE INVENTION As noted above, the present invention is generally directed to compositions and methods for the immunotherapy of prostate cancer. The inventive compositions are generally polypeptide... Read More
Inventors: Xu, Jiangchun; Dillon, Davin C.;, Assignee: Corixa Corporation (Seattle, WA) |
Compositions and methods for the therapy and diagnosis of prostate cancer
Briefly stated, the present invention provides compositions and methods for the diagnosis and therapy of cancer, such as prostate cancer. In one aspect, the present invention provides polypeptides com... Read More
Inventors: Xu, Jiangchun; Dillon, Davin C.; Mitcham, Jennifer L.; Harlocker, Susan L.; Jiang, Yuqiu; Kalos, Michael D.; Fanger, Gary R.; Retter, Marc W.; Stolk, John A.; Day, Craig H.; Vedvick, Thomas S.; Carter, Darrick; Li, Samuel X.; Wang, Aijun; Skeiky, Yasir A., Assignee: Corixa Corporation (Seattle, WA) |
Superantigen based methods and compositions for treatment of diseases
What is claimed is: 1. A pharmaceutical compound comprising a therapeutic antigen and superantigen, wherein said super antigen is conjugated to the therapeutic antigen and wherein the therapeutic anti... Read More
Inventors: Terman, David Stephen;, Assignee: |
Tetra and penta-peptides useful in regulating the immune system
The present invention describes a series of thysplenin peptide analogs capable of regulating the function of cells of the immune system. As one aspect, the present invention relates to novel tetrapept... Read More
Inventors: Heavner, George; Goldstein, Gideon; Audhya, Tapan;, Assignee: Immunobiology Research Institute, Inc. (Annandale, NJ) |
Peptide fragments of myelin basic protein
OF THE INVENTION All patent applications, patents and publications cited in this specification are hereby incorporated by reference in their entirety. In the case of inconsistencies, the present disc... Read More
Inventors: Weiner, Howard L.; Hafler, David A.;, Assignee: Autoimmune, Inc. (Lexington, MA) |
Targeted therapeutic delivery of vitamin D compounds
The present invention provides conjugates of vitamin D compounds or analogs and a targeting molecule, having an ability for site-specific delivery of the vitamin D. Specific conjugates include a bone-... Read More
Inventors: Mazess, Richard B.; Bishop, Charles W.;, Assignee: Bone Care International, Inc. (Madison, WI) |
Production and use of monoclonal antibodies to phosphotyrosine-containing proteins
OF THE PREFERRED EMBODIMENTS A hybridoma secreting monoclonal antibodies that bind to PT-residues of PT-proteins was isolated from a fusion of Sp 2/0 cells with spleen cells of mice immunized with th... Read More
Inventors: Frackelton, Jr., A. Raymond; Eisen, Herman N.; Ross, Alonzo H.;, Assignee: Massachusetts Institute of Technology (Cambridge, MA) |
Trichothecene antibody conjugates
I claim: 1. A conjugate of a trichothecene and an antibody or antibody fragment, said antibody or antibody fragment being capable of specifically binding to a defined population of cells. 2. The conju... Read More
Inventors: Pavanasasivam, Gowsala;, Assignee: NeoRx Corporation (Seattle, WA) |
Monoclonal antibody to human protein C
What is claimed is: 1. A monoclonal antibody which is specific to human protein C which has calcium bound at the gamma-carboxyglutamic acid (Gla) domain and does not recognize human protein C which is... Read More
Inventors: Wakabayashi, Kenji; Sumi, Yoshihiko; Ichikawa, Yataro; Sakata, Yoichi; Mimuro, Jun; Aoki, Nobuo;, Assignee: Teijin Limited (Osaka, JP) |
Method for providing a cell culture from a transgenic non-human mammal
We claim: 1. A method of providing a cell culture comprising (1) providing a transgenic non-human mammal, all of whose germ cells and somatic cells contain a recombinant activated oncogene sequence in... Read More
Inventors: Leder, Philip; Stewart, Timothy A.;, Assignee: President and Fellows of Harvard College (Cambridge, MA) |
Method of gene transfer into chickens and other avian species
A method is described for introducing foreign genes or foreign nucleic acid sequences into somatic and/or germ cells of the chicken and other avian species. A replication-defective retroviral vector i... Read More
Inventors: Bosselman, Robert A.; Hu, Shaw-Fen S.; Nicolson, Margery A.;, Assignee: Amgen Inc. (Thousand Oaks, CA); Arbor Acres Farm, Inc. (Glastonbury, CT) |
DNA vector with isolated CDNA gene encoding metallopanstimulin
The present invention is based upon the discovery of a new and heretofore unrecognized type of cellular mRNA sequence and its encoded protein, designated as metallopanstimulin (MPS). One specific form... Read More
Inventors: Fernandez-Pol, Jose A.;, Assignee: |
Method for preparing immunoglobulin fragments
Pursuant to the present invention, there is provided an improved method for specific fragmentation of immunoglobulins and recovery of the fragments. Through the use of soluble protease (in particular,... Read More
Inventors: Ngo, That T.; Kumar, Harish P. M.;, Assignee: UniSyn Technologies, Inc. (Tustin, CA) |
Morpholino-subunit combinatorial library and method
The invention includes, in one aspect, a combinatorial library of non-biological oligomers formed predominantly of morpholino subunit structures of the form: ##STR1## where (i) the structures are link... Read More
Inventors: Summerton, James E.; Weller, Dwight D.;, Assignee: Antivirals Inc. (Corvallis, OR) |
Method of producing transgenic animals
What is claimed is: 1. A method for transferring DNA into fertilized eggs of a non-human mammal, comprising: subjecting a mixture of said DNA and said fertilized eggs to pulses of an electric field fo... Read More
Inventors: Zhao, Xi; Wong, Tai-kin;, Assignee: Incell (Santa Clara, CA) |
Humanized immunoglobulins
OF THE INVENTION In accordance with the present invention, novel means of designing humanized immunoglobulins capable of specifically binding to a predetermined antigen with strong affinity are provi... Read More
Inventors: Queen, Cary L.; Co, Man Sung; Schneider, William P.; Landolfi, Nicholas F.; Coelingh, Kathleen L.; Selick, Harold E.;, Assignee: Protein Design Labs, Inc. (Mountain View, CA) |
Recombinant retroviruses
Briefly stated, the present invention provides recombinant retroviruses carrying a vector construct capable of preventing, inhibiting, stabilizing or reversing infectious, cancerous, auto-immune or im... Read More
Inventors: Gruber, Harry E.; Jolly, Douglas J.; Respess, James G.; Laikind, Paul K.;, Assignee: Chiron Viagene, Inc. () |
Transgenic bovine
In accordance with the above objects, the invention includes transgenes for producing recombinant polypeptides in the milk of transgenic bovine species. The production of such transgenic bovine milk c... Read More
Inventors: Deboer, Herman A.; Strijker, Rein; Heyneker, Herbert L.; Platenburg, Gerard; Lee, Sang He; Pieper, Frank; Krimpenfort, Paul J. A.;, Assignee: Pharming B.V. (Leiden, NL) |
Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules
OF THE INVENTION The present invention provides a method of producing antigen-combining molecules (or antibodies) which does not require an in vivo immunization procedure and which makes it possible ... Read More
Inventors: Wigler, Michael H.; Sorge, Joseph A.;, Assignee: Stratagene (La Jolla, CA) |
Method for production of monoclonal antibodies in chimeric mice or rats having xenogeneic antibody-producing cells
OF THE PREFERRED EMBODIMENTS In an preferred embodiment, the present invention relates generally to the production and use of non-human chimeric M4 mammals derived from M1 mammals having their natura... Read More
Inventors: Reisner, Yair;, Assignee: Yeda Research and Development Co. Ltd. (Rehovot, IL) |
Lipid binding protein 4
1. An isolated polypeptide selected from one of the groups consisting of: (a) a polypeptide encoded by a polynucleotide comprising the sequence of SEQ ID NO:1 or SEQ ID NO:3; (b) a polypeptide compris... Read More
Inventors: Grell, Matthias; cker, Klaus;, Assignee: Merck Patent GmbH (Darmstadt, DE) |
Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies
OF THE PREFERRED EMBODIMENTS I. Definitions An "ErbB receptor" is a receptor protein tyrosine kinase which belongs to the ErbB receptor family and includes EGFR, ErbB2, ErbB3 and ErbB4 receptors and ... Read More
Inventors: Sliwkowski, Mark;, Assignee: Genentech, Inc. (South San Francisco, CA) |
Tumor killing effects of enterotoxins, superantigens, and related compounds
What is claimed is: 1. A mammalian cell comprising an exogenous nucleic acid encoding a superantigen or a biologically active fragment of a superantigen that stimulates T cells via the T cell receptor... Read More
Inventors: Terman, David S.;, Assignee: |
Drugs 
