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| Latest patents |
Results: 271-300 of 3116
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Vaccine against Staphylococcus intoxication
The present invention satisfies the need discussed above. The present invention relates to a method and composition for use in inducing an immune response which is protective against intoxication with... Read More
Inventors: Lee, John S.; Pushko, Peter; Smith, Jonathan F.; Ulrich, Robert G.;, Assignee: The United States of America as represented by the Secretary of the Army (Washington, DC) |
Mutants of Streptococcal toxin C and methods of use
OF THE INVENTION This invention is directed to mutant SPE-C toxins and fragments thereof, vaccine and pharmaceutical compositions including mutant SPE-C toxins or fragments thereof, methods of prepar... Read More
Inventors: Schlievert, Patrick M.; Ohlendorf, Douglas; Mitchell, David T.; Gahr, Pamala J.;, Assignee: Regents of the University of Minnesota (Minneapolis, MN) |
Mutants of Streptococcal toxin A and methods of use
OF THE INVENTION This invention is directed to mutant SPE-A toxins and fragments thereof, vaccine and pharmaceutical compositions including mutant SPE A toxins or fragments thereof, methods of prepar... Read More
Inventors: Schlievert, Patrick M.; Roggiani, Manuela; Stoehr, Jennifer Stoehr; Ohlendorf, Douglas;, Assignee: Regents of the University of Minnesota (Minneapolis, MN) |
Method for inducing a cell-mediated immune response and improved parenteral vaccine formulations thereof
It has now been surprisingly found that polarisation of the T.sub.H1 immune response over the T.sub.H2 immune response or that polarisation of the T.sub.H2 immune response over the T.sub.H1 immune res... Read More
Inventors: Brayden, David J.;, Assignee: Merrion Research I Limited (Dublin, IE) |
Chemiluminescent compounds and methods of use
What is claimed is: 1. A compound of the formula: ##STR32## wherein: X is NH and Y is independently selected from the group consisting of O and S; and Z is a chain, 2 atoms in length, which atoms are ... Read More
Inventors: Singh, Sharat; Singh, Rajendra; Meneghini, Frank; Ullman, Edwin F.;, Assignee: Behringwerke AG (Marburg, DE) |
Method and compositions for preventing and treating the systemic inflammatory response syndrome including sepsis
Accordingly, it is one object of the present invention to provide a novel method for preventing SIRS/sepsis. It is another object of the present invention to provide a novel method for treating SIRS/s... Read More
Inventors: Becker, Kenneth L.; White, Jon C.; Nylen, Eric S.; Snider, Jr., Richard H.;, Assignee: Biology Associates, LLC (Bethesda, MD) |
Peptide antagonists of zonulin and methods for use of the same
An object of the present invention is to identify peptide antagonists of zonulin. Another object of the present invention is to synthesize and purify said peptide antagonists. Still another object of ... Read More
Inventors: Fasano, Alessio;, Assignee: University of Maryland, Baltimore (Baltimore, MD) |
Ro/SSA peptide reagents for diagnosis of autoantibodies
A number of octapeptides have been generated from the sequences encoding the 60 kDa Ro/SSA peptide, the La/SSB autoantigen, the 70 kD nuclear ribonucleoprotein (nRNP), and the Sm B/B′ polypepti... Read More
Inventors: Harley, John B.;, Assignee: Oklahoma Medical Research Foundation (Oklahoma City, OK) |
Inactivated respiratory syncytial viral vaccines
OF THE INVENTION In one aspect, the present invention relates to the preparation of an inactivated respiratory syncytial virus under conditions acceptable for use in human vaccines. RS virus, subtype... Read More
Inventors: Sanhueza, Sonia E.; Ewasyshyn, Mary E.; Klein, Michel H.;, Assignee: Sanofi Pasteur Limited (Toronto, CA) |
Cell growth inhibitory substances
OF THE INVENTION The Organism Taxonomy: Dolabella species belong to the family Aplysidae, the class Gastropoda and the phylum Mollusca. In a reference by H. Engel in "Zoologische Mededeelingen," Leid... Read More
Inventors: Pettit, George R.;, Assignee: University Patents, Inc. (Tempe, AZ) |
Mimotopes and anti-mimotopes of human platelet glycoprotein Ib/IX
What is claimed is: 1. An isolated peptide of 5 to 20 or 20 to 40 amino acids residues in length capable of binding to a second peptide having an amino acid sequence as shown in SEQ ID NO:174, wherein... Read More
Inventors: Miller, Jonathan L.; Lyle, Vicki A.;, Assignee: The Research Foundation of State University of New York (Albany, NY) |
Ileus treatment method
The present invention is directed to a method of treating or preventing post-operative ileus in a mammalian subject. The method includes administering to the subject, a pharmaceutically effective amou... Read More
Inventors: Bunnett, Nigel W.; Corvera, Carlos U.;, Assignee: The Regents of the University of California (Oakland, CA) |
Ileus treatment method
OF THE INVENTION The present invention for treating or preventing post-operative ileus is based on the discoveries herein that (i) proteinase-activated receptor 2 is expressed in colonic muscle cells... Read More
Inventors: Bunnett, Nigel W.; Corvera, Carlos U.;, Assignee: The Regents of the Uinversity of California (San Francisco, CA) |
Methods for the treatment and prevention of ileus
Accordingly, the present invention is directed, in part, to novel methods for treating and/or preventing ileus. Specifically, in one embodiment, there are provided novel methods of treating or prevent... Read More
Inventors: Farrar, John J.; Schied, Peter J.; Schmidt, William K.; Carpenter, Randall L.;, Assignee: Adolor Corporation (Exton, PA) |
Pharmaceutical angiostatic dipeptide compositions and methods of use thereof
OF THE INVENTION The present invention provides pharmaceutical Glu-Trp preparations comprising an R′-Glu-Trp-R"; dipeptide and a pharmaceutically acceptable carrier. R′-Glu-Trp-R"; dipe... Read More
Inventors: Green, Lawrence R.; Blasecki, John W.;, Assignee: Melmotte, Inc. (Morrisville, NC) |
Antibodies to human IL-8 type B receptor
In one aspect, the invention provides an anti-IL8R-BH antibody. In another aspect, the invention provides a composition comprising the anti-IL8R-BH antibody and a pharmaceutically acceptable carrier, ... Read More
Inventors: Chuntharapai, Anan; Hebert, Caroline; Kim, Kyung J.; Lee, James;, Assignee: |
DNA encoding epithelium-derived T-cell factor
A novel T-cell growth factor, hereinafter referred to as "epithelium-derived T-cell factor" ("ETF"), has been isolated and purified. A cDNA sequence encoding a simian ETF polypeptide was isolated that... Read More
Inventors: Grabstein, Kenneth; Anderson, Dirk; Eisenman, June; Fung, Victor; Rauch, Charles;, Assignee: Immunex Corporation (Seattle, WA) |
Method for treating or preventing gastrointestinal disease with epithelium-derived T-cell factor
As noted above, the present invention provides novel T-cell growth factors, hereinafter referred to as "Epithelium-derived T-cell Factors" ("CETF"). Briefly, within one aspect of the present invention... Read More
Inventors: Grabstein, Kenneth H.; Anderson, Dirk M.; Eisenman, June R.; Fung, Victor; Rauch, Charles;, Assignee: Immunex Corporation (Seattle, WA) |
Epithelium-derived T-cell factor antibodies
As noted above, the present invention provides novel T-cell growth factors, hereinafter referred to as "Epithelium-derived T-cell Factors" ("ETF"). Briefly, within one aspect of the present invention ... Read More
Inventors: Grabstein, Kenneth H.; Anderson, Dirk M.; Eisenman, June R.; Fung, Victor; Rauch, Charles;, Assignee: Immunex Corporation (Seattle, WA) |
Activity-dependent neurotrophic factor
It is an object of the present invention to provide a purified ADNF protein. The purified protein of the present invention increases the survival of activity-dependent spinal cord neurons and cerebral... Read More
Inventors: Brenneman, Douglas E.; Gozes, Illana;, Assignee: The United States of America as represented by the Department of Health (Washington, DC) |
Treatment of hypertension using growth hormone in mammals subjected to fetal programming
Accordingly, in a first aspect the present invention provides a method of treating hypertension in a mammal, which has experienced intrauterine under nutrition and/or growth retardation or an adverse ... Read More
Inventors: Vickers, Mark H.; Breier, Bernhard H. H.; Ikenasio, Betina A.;, Assignee: Auckland Uniservices Limited (Auckland, NZ) |
Cosmetic and dermatological preparations comprising increased electrolyte concentrations
1. A cosmetic or dermatological preparation comprising a stabilized oil-in-water (o/w) emulsion having one or more aqueous phases, and further comprising: (I) one or more partially neutralized esters ... Read More
Inventors: Gü, nther; Hamer, Gunhild; Bleckmann, Andreas; Fecht, Stephanie von der;, Assignee: Beiersdorf AG (Hamburg, DE) |
Human galectins
What is claimed is: 1. An isolated and purified polynucleotide sequence encoding a polypeptide comprising the amino acid sequence of SEQ ID NO:1. 2. A hybridization probe comprising of the polynucleot... Read More
Inventors: Hillman, Jennifer L.; Goli, Surya K.; Bandman, Olga; Hawkins, Phillip R.; Petithory, Joanne R.;, Assignee: Incyte Pharmaceuticals, Inc. (Palo Alto, CA) |
Prostate associated Ets protein
1. An isolated polypeptide sequence selected from the group consisting of: a) a polypeptide comprising the amino acid sequence of SEQ ID NO:1, and b) a polypeptide that is least 95% identical to the a... Read More
Inventors: Bandman, Olga; Guegler, Karl J.; Lal, Preeti; Corley, Neil C.;, Assignee: Incyte Corporation (Wilmington, DE) |
Long-acting biocidal compositions and method therefor
Accordingly, it is a general object of the present invention to avoid or substantially alleviate the above-discussed problems of the prior art. A more specific object of the invention is to provide bi... Read More
Inventors: Tice, Thomas R.; Meyers, William E.; Gilley, Richard M.; Shannon, William M.;, Assignee: Southern Research Institute (Birmingham, AL) |
Method for the cleansing of wounds using an aerosol container having liquid wound cleansing solution
In general, it is an object of the present invention to provide an aerosol hand-held container and method for the cleaning of wounds. Another object of the invention is to provide a container and meth... Read More
Inventors: Sperry, Charles R.; Raff, Allan M.;, Assignee: Dey Laboratories, Inc. (Napa, CA) |
Process of making a resorbable implantation device
The present invention relates broadly to resorbable materials produced by the gelation of a solution of an independently-gelling single polylactide enantiomer. The term "single polylactide enantiomer"... Read More
Inventors: Coombes, Allan G. A.; Heckman, James D.; Boyan, Barbara D.;, Assignee: Board of Regents, The University of Texas System (Austin, TX) |
Phase separation-microencapsulated pharmaceuticals compositions useful for alleviating dental disease
OF THE INVENTION The present invention provides a core material surrounded by a coating or encapsulating substance which is normally a polymer. Among the encapsulating polymers which can be utilized,... Read More
Inventors: Lawter, James R.; Lanzilotti, Michael G.;, Assignee: American Cyanamid Company (Madison, NJ) |
Sustained release formulations of water soluble peptides
What is claimed is: 1. A microparticle having a diameter of between 1 and 250 microns comprising octreotide, in a free base, acid addition salt or complex form in a biodegradable, biocompatible polyme... Read More
Inventors: Bodmer, David; Fong, Jones W.; Kissel, Thomas; Maulding, Hawkins V.; Nagele, Oskar; Pearson, Jane E.;, Assignee: Sandoz Ltd. (Basel, CH) |
Vaccines against intracellular pathogens using antigens encapsulated within biodegradble-biocompatible microspheres
We claim: 1. An immunostimulating composition comprising encapsulating microspheres comprised of (a) a biodegradable-biocompatible poly(DL-lactide-co-glycolideas the bulk matrix produced by a solvent ... Read More
Inventors: Burnett, Paul R.; Van Hamont, John E.; Reid, Robert H.; Setterstrom, Jean A.; Van Cott, Thomas C.; Birx, Debrah L.;, Assignee: The United States of America as represented by the Secretary of the Army (Washington, DC) |
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