Multiple drug resistance gene of Cryptococcus neoformans
OF THE INVENTION The present invention provides isolated nucleic acid molecules that comprise a nucleic acid sequence encoding CneMDR1. The cDNA (complementary deoxyribonucleic acid) sequence encodin... Read More
Inventors: Peery, Robert Brown; Skatrud, Paul Luther; Thornewell, Susan Jane;, Assignee: Eli Lilly and Company (Indianapolis, IN) |
Glucuronide repressors and uses thereof
This invention generally provides isolated nucleic acid molecules encoding a glucuronide repressor. In particular, a nucleotide and amino acid sequence of the E. coli glucuronide repressor (gusR) are ... Read More
Inventors: Jefferson, Richard A.; Wilson, Katherine J.; Leader, Michael;, Assignee: Cambia Biosystems LLC (Bellevue, WA) |
Recombinant Bacillus anthracis strains unable to produce the lethal factor protein or edema factor protein
We claim: 1. A recombinant strain of Bacillus anthracis which induces in a human or animal host the production of protective antibodies against a virulent strain of Bacillus anthracis, wherein said re... Read More
Inventors: Mock, Michele; Cataldi, Angel; Pezard, Corinne;, Assignee: Institut Pasteur (Paris Cedex, FR) |
Bispecific antibody determinants
What is claimed is: 1. A process for preparing covalent hybrid antibodies comprising the steps of: A) selectively cleaving a first monoclonal immunoglobulin molecule which is an antibody to a first an... Read More
Inventors: Paulus, Henry P.;, Assignee: Boston Biomedical Research Institute, Inc. (Boston, MA) |
Genes coding for a protein having human MACIF activity, expression vectors containing said genes, transformant cells and proteins having human macif activity
The present invention provides genes respectively coding for polypeptides having human MACIF activity in which an amino acid sequence is represented by the following general formula (I): ##STR2## In t... Read More
Inventors: Tomita, Motowo; Sugita, Yuji; Takemoto, Toshiyuki; Furuichi, Kiyoshi; Takayama, Makoto; Yasukawa, Ko; Ito, Katsuhisa; Yamaji, Noboru; Yano, Shinya;, Assignee: Yamanouchi Pharmaceutical Co., Ltd. () |
Method and kit for diagnosis of diseases
Broadly stated, the diagnostic method of the present invention comprises the following steps: Purified viral, fungal, bacterial or parasitic antigen is collected in the presence of a detergent. An opt... Read More
Inventors: Christensen, Dale A.; Nash, Peter;, Assignee: |
Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
The invention relates to the discovery that a new class of biomaterials derived from peptides related to the yeast DNA binding protein zuotin. The oligopeptides are generally stable in aqueous solutio... Read More
Inventors: Holmes, Todd; Zhang, Shuguang; Rich, Alexander; DiPersio, C. Michael; Lockshin, Curtis;, Assignee: Massachusetts Institute of Technology (Cambridge, MA) |
Enhancement of antigen immunogenicity
What is claimed is: 1. A novel conjugate physiologically suitable for administration to a mammal to elicit an immune response, comprising at least one antigen which is a peptide or protein bonded to a... Read More
Inventors: Barber, Brian H.; Carayannotis, George;, Assignee: Connaught Laboratories Limited (Willowdale, CA) |
Fused antigen polypeptide
The present inventors have studied about production of useful antigen polypeptides and established a method for producing a hybrid antigen polypeptide wherein two or more antigen polypeptides are fuse... Read More
Inventors: Kuga, Tetsuro; Sekine, Susumu; Itoh, Seiga;, Assignee: Kyowa Hakko Kogyo Co., Ltd. (Tokyo, JP) |
Amiloride-sensitive sodium channel and method of identifying substances which stimulate or block salty taste perception
A cloned subunit (.alpha.subunit) of the amiloride-sensitive salt channel has now been discovered to be localized to the tongue, including taste tissue, and has been identified as having a role in sal... Read More
Inventors: Li, Xiao-Jiang; Blackshaw, Seth; Snyder, Solomon H.;, Assignee: The Johns Hopkins University (Baltimore, MD) |
Interferon polymer conjugates
In one aspect, the present invention includes pharmaceutical compositions containing a mixture of mono-polymer stranded alpha interferon conjugates. In the mixture, individual mono-polymer-IFN conjuga... Read More
Inventors: Gilbert, Carl W.; Park-Cho, Myung-ok;, Assignee: Enzon, Inc. (Piscataway, NJ) |
Immortalized cell lines for virus growth
OF THE PREFERRED EMBODIMENTS At present there are essentially no non-viral, non-viral protein or non-chemically transformed avian cell lines available. Primary cell lines are cumbersome to continuall... Read More
Inventors: Foster, Douglas N.; Foster, Linda K.;, Assignee: Regents of the University of Minnesota () |
Polypeptides, and preparation and DNA encoding thereof
OF THE INVENTION AND PREFERRED EMBODIMENT That is, this invention provides polypeptides shown by following 1)-6). 1) A polypeptide at least having a primary structure of amino acid sequence shown by ... Read More
Inventors: Iwanaga, Sadaaki; Kawabata, Shun-ichiro; Saito, Tetsu;, Assignee: Seikagaku Kogyo Kabushiki Kaisha (JP) |
Screening assays to identify agents that modulate cisplatin resistance
This invention pertains to an isolated nucleic acid molecule which can confer high level cisplatin resistance on a cell in which the nucleic acid is expressed. In a preferred embodiment, expression of... Read More
Inventors: Yokoyama, Shiro;, Assignee: |
Method of restoring normal growth, weight gain or lean body mass in patients with glucocorticoid excess by administering IGF-I
Accordingly, the present invention provides a method for at least partially restoring normal growth, weight gain, and lean body mass of a mammal with glucocorticoid excess comprising administering to ... Read More
Inventors: Hahn, Theodore J.; Rudman, Christopher G.;, Assignee: Genentech, Inc. (South San Francisco, CA) |
Thiocarboxylate ester compounds compositions containing the same
Treatments and drugs that satisfy this need have now been developed. In accordance with one aspect of the present invention, a method for inhibiting the growth or replication of HIV is provided, which... Read More
Inventors: Harrison, William A.; Felauer, Ethel E.; Brouwer, Walter G.;, Assignee: Uniroyal Chemical Company, Inc. (Middlebury, CT); Uniroyal Chemical Ltd./Ltee (Elmira, CA) |
Fluid bed process for the acetoxylation of ethylene in the production of vinyl acetate
OF THE INVENTION In general, the process of the present invention comprises the manufacture of vinyl acetate in a fluid bed reactor comprising feeding a gaseous mixture comprising ethylene and acetic... Read More
Inventors: Cirjak, Larry M.; Lemanski, Michael F.; Wagner, David R.; Benkalowycz, Nancy C.; Blum, Patricia R.; Pepera, Marc A.; Paparizos, Christos;, Assignee: |
Methods of immunization of poultry with vaccines against chicken anemia agent (CAA)
I claim: 1. A method of vaccinating poultry against chicken anemia agent (CAA) virus, comprising administering a vaccine composition containing an immunogenically effective amount of live attenuated C... Read More
Inventors: Schrier, Carla Christina;, Assignee: Akzo Nobel N.V. (Arnhem, NL) |
Universal linker for combinatorial synthesis
OF THE INVENTION Abbreviations and Definitions The following abbreviations and terms have the indicated meanings throughout: Ac=acetyl BNB=4-bromomethyl-3-nitrobenzoic acid Boc=t-butyloxy carbonyl Bu... Read More
Inventors: Li, Ge; Griffiths, Sian Louise; McDonald, Edward; Xu, Libo;, Assignee: Pharmacopeia, Inc. (Princeton, NJ) |
Method for detecting nucleic acids through a triple-stranded DNA intermediate without denaturing
OF THE INVENTION recA protein used in the present invention is originally a protein responsible for a recombination reaction involved in a kind of DNA repair reaction, by which a mutation site result... Read More
Inventors: Shigemori, Yasushi; Fujiwara, Jun;, Assignee: Aisin Cosmos R & D Co., Ltd. (JP) |
Immunogenic compositions comprising DAL/DAT double-mutant, auxotrophic, attenuated strains of Listeria and their methods of use
The invention includes a method of eliciting a T cell immune response to an antigen in a mammal comprising administering to the mammal an auxotrophic attenuated strain of Listeria which expresses the ... Read More
Inventors: Frankel, Fred R.; Portnoy, Daniel A.;, Assignee: The Trustees of the University of Pennsylvania (Philadelphia, PA) |
Plant pest control
What is claimed is: 1. An isolated receptor to a VIP3A(a) protein of SEQ ID NO:2, wherein said receptor is isolated from the midgut of black cutworm larvae. 2. An isolated DNA molecule comprising a se... Read More
Inventors: Estruch, Juan Jose; Yu, Cao-Guo;, Assignee: Syngenta Participations AG (Basel, CH) |
Bovine viral diarrhea virus serum antigen capture
What is claimed is: 1. A method of detecting whether a target animal is Bovine Viral Diarrhea Virus positive or negative comprising: a) providing at least one sample taken from said target animal, whe... Read More
Inventors: Huchzermeier, Roy; Dubovi, Edward Joseph;, Assignee: Cornell Research Foundation, Inc. (Ithaca, NY); Syracuse Bioanalytical, Inc. (Ithaca, NY) |
Tumor necrosis factor receptor-II-associated protein kinase and methods for its use
The present invention identify proteins that associate with the cytoplasmic domain of the p80 form of the TNF receptor. The present invention provides evidence of physical and functional association o... Read More
Inventors: Aggarwal, Bharat B.; Darnay, Bryant G.;, Assignee: Research Development Foundation (Carson City, NV) |
***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST*** *** NO IMAGES AVAILABLE***
Description:... Read More
Inventors: , Assignee: |
Fungal target genes and methods
OF THE INVENTION In a preferred embodiment, the proteins having AG007, AG008, AG009, AG010, and AG011 activities are encoded by nucleotide sequences derived from fungi, preferably filamentous fungi, ... Read More
Inventors: Gaffney, Thomas Deane; Flavier, Albert; Gates, Krista; Wendland, Jurgen; Ayad-Durieux, Yasmina; Dietrich, Fred; Philippsen, Peter;, Assignee: Syngenta Participations AG (Basel, CH) |
Thermal baffle for fast-breeder reacton
According to the present invention, a bridge structure for separating hot outlet coolant from cool inlet coolant in a liquid-metal-cooled fast-breeder reactor includes an annular austenitic stainless ... Read More
Inventors: Rylatt, John A.;, Assignee: The United States of America as represented by the United States Energy (Washington, DC) |
Patched antibodies
Methods for isolating patched genes, particularly mammalian patched genes, including the mouse and human patched genes, as well as invertebrate patched genes and sequences, are provided. The methods i... Read More
Inventors: Scott, Matthew P.; Goodrich, Lisa V.; Johnson, Ronald L.;, Assignee: The Board of Trustees of the Leland S. Stanford University () |
Chimeric proteins which block complement activation
The drawings will first be briefly described. FIG. 1 is a diagram showing the proteins of the complement system, their pathways of activation, and the proteins regulating their function. FIG. 2 is a ... Read More
Inventors: Ko, Jone-Long; Yeh, C. Grace;, Assignee: Cytomed, Inc. (Cambridge, MA) |
Biotherapeutic delivery system
General Overview The SEQ ID NO: 2 protein is a protein that has efficient intercellular transport. When the protein is introduced via DNA constructs that express it, following expression in a sub-pop... Read More
Inventors: Harms, Jerome S.; Splitter, Gary A.;, Assignee: Wisconsin Alumni Research Foundation (Madison, WI) |
Drugs 
