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| Latest patents |
Results: 2911-2940 of 3116
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NMDA antagonists
What is claimed is: 1. A method for preventing or minimizing damage to nervous tissues contained within the central nervous system resulting from exposure to ischemic or hypoxic conditions selected fr... Read More
Inventors: Whitten, Jeffrey P.;, Assignee: Merrell Pharmaceuticals Inc. (Cincinnati, OH) |
Method for increasing conversion efficiency for oxidation of an alkyl aromatic compound to an aromatic carboxylic acid
The present invention is an improvement in a method and in a system for the continuous production of an aromatic carboxylic acid by liquid phase oxidation of an aromatic alkyl in an oxydation reactor.... Read More
Inventors: Huber, Jr., William F.; Zeitlin, Martin A.;, Assignee: Amoco Corporation (Chicago, IL) |
Phosphinylalkanoyl substituted prolines
OF THE INVENTION The compounds of formula I, and salts thereof, are hypotensive agents. They inhibit the conversion of the decapeptide angiotensin I to angiotensin II and, therefore, are useful in re... Read More
Inventors: Petrillo, Jr., Edward W.;, Assignee: E. R. Squibb & Sons, Inc. (Princeton, NJ) |
Mercaptocycloalkylcarbonyl and mercaptoarylcarbonyl dipeptides
OF THE INVENTION This invention in its broadest aspects relates to the mercaptocycloalkylcarbonyl and mercaptoarylcarbonyl dipeptide compounds of formula I above, to compositions and the method of us... Read More
Inventors: Weller, III, Harold N.; Gordon, Eric M.; Delaney, Norma G.;, Assignee: E. R. Squibb & Sons, Inc. (Princeton, NJ) |
Process for preparing (.+-.)-2,3-dihydro-1H-pyrrolo[1,2-A]pyrrole-1,7-dicarboxylates
OF THE INVENTION Definitions Unless otherwise stated, the following terms used in the specification and claims have the meanings given below: "lower alkyl", denoted generally by R (which may also den... Read More
Inventors: Fleming, Michael P.; Khatri, Hiralal N.; Schloemer, George C.;, Assignee: Syntex (U.S.A.) Inc. (Palo Alto, CA) |
Thermostable xylosidase produced by Bacillus stearothermophilus NRRL B-18659, Bacillus stearothermophilus NRRL B-18660 and Bacillus stearothermophilus NRRL B-18661
OF INVENTION 4.1 Methods for Enzyme Activity Analyses Xylanase was determined by assaying for reducing sugars released from oat spelt xylan (XIU) or by the release of soluble dyed fragments from Rema... Read More
Inventors: Zamost, Bruce L.; Elm, Dana D.;, Assignee: Novo Nordisk A/S (Bagsvaerd, DK) |
Methods and compositions employing unique mixtures of polar and neutral lipids for protecting the gastrointestinal tract
In its most general and overall scope, the present invention is directed to the realization that by treating the luminal surface of the gastrointestinal tract with an agent having the ability to incre... Read More
Inventors: Lichtenberger, Lenard M.;, Assignee: Board of Regents, The University of Texas System (Austin, TX) |
Substituted guanidine compounds in the treating of arrythmias
What is claimed is: 1. A method for the treatment of cardiac arrhythmias in a mammal which has had cardiac arrythmias which comprises the administration to the mammal of a non-toxic, effective antiarr... Read More
Inventors: Maxwell, Robert Arthur; Walton, Eric;, Assignee: Burroughs Wellcome Co. (Research Triangle Park, NC) |
Adamantyl containing guanidines
OF THE INVENTION In accordance with this invention there are provided compounds hereafter referred to as Group A of FIG. 1 ##STR2## wherein R.sub.1 and R.sub.2 are the same or different and when R.su... Read More
Inventors: DuCharme, Donald W.; Skaletzky, Louis L.;, Assignee: The Upjohn Company (Kalamazoo, MI) |
Guanidine derivatives
What we claim is: 1. A compound of the formula: ##STR13## wherein R.sup.1 is selected from the group consisting of adamantyl, bicyclo[2,2,1]heptanyl, bicyclo[2,2,1]hept-5-enyl, tricyclo[2,2,1,0.sup.2,... Read More
Inventors: Swallow, Douglas Lintin;, Assignee: Imperial Chemical Industries Limited (London, EN) |
Therapeutic agents
We claim as our invention: 1. A method of inducing a central nervous system depressant response in mammals to reduce hyperexcitability and induce sedation which comprises administering to a mammal an ... Read More
Inventors: Kodama, Jiro K.; Haynes, George R.; Albert, James R.;, Assignee: Shell Oil Company (Houston, TX) |
Styrylamidines
What is claimed is: 1. A method for preventing aggregation of blood platelets in a mammal having a thromboembolic condition which comprises administering to said mammal an antithrombogenic effective d... Read More
Inventors: Matier, William L.; Comer, William T.;, Assignee: Mead Johnson & Company (Evansville, IN) |
1-Methylene-1-phenylguanidine compounds
We claim: 1. A method for ganglionic blocking which comprises administering an effective amount of a compound of the formula ##STR4## and the pharmaceutically acceptable salts thereof, wherein X.sub.1... Read More
Inventors: Douglas, George H.; Campbell, Henry F.;, Assignee: William H. Rorer, Inc. (Fort Washington, PA) |
Process for the preparation of N,N'-disubstituted guanidines
OF THE INVENTION Depending on the reaction conditions, the novel process can be based on the following overall equations: ##STR5## As is apparent from the above equations, readily available starting ... Read More
Inventors: Bergfeld, Manfred; Eisenhuth, Ludwig; Zengel, Hans;, Assignee: Akzo N.V. (Arnhem, NL) |
Salts of N-nitrosophenylhydroxylamine
OF THE INVENTION AND THE MANNER AND PROCESS OF MAKING AND USING IT The (stoichiometric or non-stoichiometric) salts of NPHA comprising a mono-, di- or higher substituted basic salt of our organic ami... Read More
Inventors: Upmacis, Rita K.; Bauer, Jr., William; Reed, Jr., Samuel F.;, Assignee: Rohm and Haas Company (Philadelphia, PA) |
Hydroxy-, alkoxy- and benzyloxy-substituted phospholipids
What is claimed is: 1. A compound of the formula wherein R.sup.1 is selected from the group consisting of hydrogen, ##STR17## wherein a is an integer having a value of 0 to 2, inclusive, X is selected... Read More
Inventors: Tegeler, John J.; Shoger, Kirk D.;, Assignee: Hoechst-Roussel Pharmaceticals Incorporated (Somerville, NJ) |
Use of nuclear magnetic resonance to identify ligands to target biomolecules
In one aspect, the present invention provides a process of screening compounds for biological activity to identify ligands that bind to a specific target molecule. That process comprises the steps of:... Read More
Inventors: Fesik, Stephen W.; Hajduk, Philip J.;, Assignee: Abbott Laboratories (Abbott Park, IL) |
Process for preparing esters of carboxylic acids
OF THE DRAWING Suitable esterification catalysts are any acidic catalysts (H.sup.+ form) such as ion exchange resins (Lewatit.RTM. supplied by Bayer). The pressure and thus the reaction temperature m... Read More
Inventors: Bessling, Bernd; Lohe, Bernd; Welker, Rudiger; Disteldorf, Walter; Knab, Jean Werner;, Assignee: BASF Aktiengesellschaft (Ludwigshafen, DE) |
Method for the preparation and recovery of alkali metal citrates
What is claimed is: 1. A method for the recovery of solid sodium, potassium or ammonium tri-citrate which comprises the steps of: a) providing an aqueous solution of citric acid; b) adding Na.sub.2 Co... Read More
Inventors: Alon, Alexander; Staal, Philip W.;, Assignee: Haarmann & Reimer Corp. (Springfield, NJ) |
Antiviral phosphonomethoxy nucleotide analogs having increased oral bioavailability
OF THE INVENTION The abbreviations NMP, DMF and DMPU mean, respectively, N-methylpyrrolidinone, dimethylformamide and N,N'-dimethylpropyleneurea. Heterocycle means aromatic and nonaromatic ringed moi... Read More
Inventors: Arimilli, Murty N.; Cundy, Kenneth C.; Dougherty, Joseph P.; Kim, Choung U.; Oliyai, Reza; Stella, Valentino J.;, Assignee: Gilead Sciences, Inc. (Foster City, CA) |
Sulfur-containing phosphonate compounds, pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism
OF THE INVENTION Novel Sulfur-containing Phosphonate Compounds The novel sulfur-containing phosphonic acid compounds of the present invention, and the pharmaceutically-acceptable salts and esters the... Read More
Inventors: Francis, Marion David; Kaas, Susan Mary; Ebetino, Frank Hallock;, Assignee: The Procter & Gamble Company (Cincinnati, OH) |
Indan derivatives used for treating thromboses or asthma
OF THE INVENTION This invention relates to indan derivative of the formula: ##STR3## wherein R.sup.1 is a substituted or unsubstituted phenyl group, naphthyl group or a sulfur-containing heterocyclic... Read More
Inventors: Iwakuma, Takeo; Kohno, Harumichi; Sasaki, Yasuhiko; Ikezawa, Katsuo; Odawara, Akio;, Assignee: Tanabe Seiyaku Co., Ltd. (Osaka, JP) |
Composition containing organogermanium compound and immunity adjusting agents comprising the compositions
Therefore, an object of the invention is to provide a composition, in which at least one of the compounds of Formula I is phisico-chemically and pharmacologically stabilized. Another object of the inv... Read More
Inventors: Sawai, Kiichi; Kurono, Masayasu; Awaya, Juichi; Kojima, Akio; Ninomiya, Hideako; Ishiwata, Yoshiro; Nakajima, Masahiro;, Assignee: Sanwa Kagaku Kenkyusho Co., Ltd. (Nagoya, JP) |
Gel of crosslinked hyaluronic acid for use as a vitreous humor substitute
We claim: 1. In the retinal surgery method in which a viscous fluid is introduced into an intraocular space enclosed between a rear boundary formed by the retina and a frontal boundry normally formed ... Read More
Inventors: Malson, Tomas; Lindqvist, Bengt L.;, Assignee: Pharmacia AB (Uppsala, SE) |
Nortropyl-1-alkanol derivatives as antiischemic agents
OF THE INVENTION The compounds of the present invention, having the formula (I), (II) and (III) defined above, are readily and generally prepared by nucleophilic displacement followed by reduction of... Read More
Inventors: Chenard, Bertrand L.;, Assignee: Pfizer Inc. (New York, NY) |
2-pyrrolidino-1-alkanol derivatives as antiischemic agents
OF THE INVENTION The compounds of the present invention, having the formula (I), (II) and (III) defined above, are readily and generally prepared by nucleophilic displacement followed by reduction of... Read More
Inventors: Chenard, Bertrand L.;, Assignee: Pfizer Inc (New York, NY) |
Prodrug esters of phenolic 2-piperidino-1-alkanols
I claim: 1. A compound of the formula ##STR14## wherein R is H, (C.sub.1 -C.sub.6)alkyl, (C.sub.2 -C.sub.6)alkenyl or (C.sub.2 -C.sub.6)alkynyl; X is phenyl, (C.sub.1 -C.sub.3)alkoxy or phenoxy; ##STR... Read More
Inventors: Chenard, Bertrand L.;, Assignee: Pfizer Inc. (New York, NY) |
Pyrrolidine derivatives inhibitors of leukotriene biosynthesis
What is claimed is: 1. A compound of formula 1 ##STR9## wherein R.sub.1 and R.sub.2, independently, are hydrogen, C.sub.1 -C.sub.6 alkyl, --CX.sub.3 wherein X is halo, C.sub.3 -C.sub.6 cycloalkyl, hal... Read More
Inventors: Pal, Kollol; Behnke, Mark; Adams, Julian;, Assignee: Boehringer Ingelheim Pharmaceuticals, Inc. (Ridgefield, CT) |
Dihydropyridine-5-phosphonic acid cyclic propylene ester
OF THE PREFERRED EMBODIMENTS The substituents in the formula I of the compounds of the present invention will be further illustrated as hereunder. Examples of R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.su... Read More
Inventors: Seto, Kiyotomo; Tanaka, Sakuya; Sakoda, Ryozo;, Assignee: Nissan Chemical Industries Ltd. (Tokyo, JP) |
Graduated estrogen contraceptive
I claim: 1. A method of contraception comprising the steps of sequentially-administering to a female of child bearing age: (1) for about 4 to about 7 days, a composition I containing about 0.5-1.5 mg ... Read More
Inventors: Boissonneault, Roger M.;, Assignee: Warner-Lambert Company (Morris Plains, NJ) |
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