Process for preparing 2-methyl-3,5-dialkylpyridines by dealkylation with sulfur
I claim: 1. A process for dealkylating the 2- position on a trisubstituted pyridine derivative having the formula ##STR3## where R.sub.1 is a straight chain alkyl group from about C.sub.2 -C.sub.5 and... Read More
Inventors: Goe, Gerald L.;, Assignee: Reilly Industries, Inc. (Indianapolis, IN) |
1,2-diamino-cyclobuten-3,4-dione derivatives
We claim: 1. A compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR26## wherein a and b together form an --O-- or --CH.sub.2 -- linkage or a bond; Y is C--R.sub.1 wherein eithe... Read More
Inventors: Stemp, Geoffrey; Burrell, Gordon;, Assignee: Beecham Group p.l.c. (GB2) |
Certain heterocyclic ammonio phosphate derivatives
What is claimed is: 1. A compound, inclusive of salts thereof, of the formula: ##STR14## wherein R.sup.1 is C.sub.8-26 aliphatic hydrocarbon residue, and A.sup.+ is cyclic ammonio. 2. The compound acc... Read More
Inventors: Hozumi, Motoo; Nomura, Hiroaki; Yoshioka, Yoshio;, Assignee: Takeda Chemical Industries, Ltd. (Osaka, JP) |
Glycerol derivative and anti-hypertensive agent
OF THE INVENTION In the formula (I), R.sup.1 represents a straight or branched chain alkyl group having 10-22 carbon atoms such as decyl, undecyl, dodecyl, tridecyl, tetradecyl, pentadecyl, hexadecyl... Read More
Inventors: Masaki, Mitsuo; Takeda, Hiromitsu; Kamishiro, Toshiro; Yamamoto, Masao;, Assignee: Nippon Chemiphar Co., Ltd. (Tokyo, JP) |
Preparation of N-phosphonomethylglycine
We claim: 1. A process of preparing N-phosphonomethyl-glycine having the formula: ##EQU17## which comprises reacting an N-substituted glycine derivative of the formula: ##EQU18## wherein R.sup.1 is a ... Read More
Inventors: Parry, David Rees; Tomlin, Clive Dudley Spencer;, Assignee: Imperial Chemical Industries Limited (London, EN) |
Process of producing crystalline nitrilo tris-(methylene phosphonic acid)
We claim: 1. In a process of producing substantially pure, crystalline nitrilo tris-(methylene phosphonic acid), the steps which comprise a. slowly adding a phosphorus trihalogenide selected from the ... Read More
Inventors: Krueger, Friedrich; Bauer, Lieselotte;, Assignee: Joh. A. Benckiser GmbH (Ludwigshafen am Rhein, DT) |
Methylene phosphonates of poly-diepoxidized polyalkylene polyamines
We claim: 1. Methylene phosphonates of poly-diepoxidized polyalkylene polyamines having (1) nitrogen-bonded methylene phosphonate units of the formula --CH.sub.2 PO(OM).sub.2 where M is alkali metal, ... Read More
Inventors: Quinlan, Patrick M.;, Assignee: Petrolite Corporation (St. Louis, MO) |
Process for the preparation of acylaminomethanephosphonic acids
I claim: 1. A process for the preparation of a compound of the formula I ##STR2## in which R.sup.1 is H, C.sub.1 -C.sub.6 -alkyl, benzyl or phenyl, which is unsubstituted or substituted by one or more... Read More
Inventors: Kleiner, Hans-Jerg;, Assignee: Hoechst Aktiengesellschaft (Frankfurt am Main, DE) |
Process for the preparation of a pentenoate ester
What we claim is: 1. A process for the preparation of a pentenoate ester by carbonylation of butadiene or a butadiene derivative in the presence of carbon monoxide, alcohol and a catalyst system compr... Read More
Inventors: Sielcken, Otto E.; Agterberg, Frank P. W.; Haasen, Nicolaas F.;, Assignee: DSM N.W. (Heerlen, NL); E. I. Du Pont de Nemours and Company (Wilmington, DE) |
Artificial positive controls derived from bifunctional conjugates
We claim: 1. A bi-functional conjugate comprising an antibody of nonhuman origin, wherein said conjugate has: i) a first binding site that specifically binds a specific pathogen; and ii) a second bind... Read More
Inventors: Brust, Stefan; Friesen, Heinz-Juergen; Nau, Guenther; Pauly, Hans-Erwin;, Assignee: Behringwerke Aktiengesellschaft (Marburg, DE) |
Diclofenac/gamma-cyclodextrin inclusion compounds
What is claimed is: 1. A composition comprising 50% or more by weight of a first inclusion compound formed from diclofenac or a pharmaceutically acceptable salt thereof and gamma-cyclodextrin at a mol... Read More
Inventors: Fischer, Wilfried; Sendl-Lang, Anna;, Assignee: Hexal AG (Holzkirchen, DE) |
Treatment of inflammation using 1-antichymotrypsin
OF THE PRESENT INVENTION The objects of the present invention can be achieved by the administration of purified alpha 1-antichymotrypsin in suitable pharmaceutical form to patients suffering from inf... Read More
Inventors: Lezdey, John; Wachter, Allan;, Assignee: |
Methods for treatment of conditions associated with lactosylceramide
We have now discovered therapies to treat or prevent various diseases, post-surgical disorders and bacterial infections modulated by lactosylceramide (LacCer). In particular, we have discovered therap... Read More
Inventors: Chatterjee, Subroto;, Assignee: Johns Hopkins University (Baltimore, MD) |
Gel drying via treatment with organic liquid below gas stream
We claim: 1. A process for removing water from a pre-formed, wet gel material having an open porous network which comprises contacting a pre-formed, wet gel material with an organic liquid, the amount... Read More
Inventors: Lane, Edward S.; Winter, John A.;, Assignee: United Kingdom Atomic Energy Authority (London, GB2) |
Process for producing an insulin precursor
OF THE INVENTION As indicated, this invention is directed to a process for producing an insulin precursor. As used herein, the term "insulin precursor" refers to a molecule which (1) contains an insu... Read More
Inventors: Frank, Bruce H.;, Assignee: Eli Lilly and Company (Indianapolis, IN) |
Pharmaceutical formulations comprising human insulin, human C-peptide, and human proinsulin
OF THE INVENTION The three essential constituents of the pharmaceutical compositions of this invention and administered in accordance with the method of this invention are human insulin, human C-pept... Read More
Inventors: Chance, Ronald E.; Frank, Bruce H.; Galloway, John A.;, Assignee: Eli Lilly and Company (Indianapolis, IN) |
Polyester lubricant additives, their preparation and compositions containing them
We claim: 1. A lubricating composition comprising a major amount of lubricating oil and a minor amount sufficient to impart dispersant properties to said oil of a polyester additive which is the produ... Read More
Inventors: Elliott, John S.; Davis, Bryan T.; Norman, Stephen;, Assignee: Ethyl Corporation (Richmond, VA) |
Water-soluble rosin polyamide resins
I claim: 1. A water soluble resin comprising the reaction product of (a) a rosin modified by reaction with a member of the group selected from fumaric acid, maleic acid, maleic anhydride, itaconic aci... Read More
Inventors: Hutter, G. Frederick;, Assignee: Westvaco Corporation (New York, NY) |
Process for hydrotreating resins to lighten color
OF THE INVENTION The process of this invention for contacting a colored resin with hydrogen in the presence of a catalyst is subsequently referred to as "hydrotreating". The process is a selective hy... Read More
Inventors: Daughenbaugh, Norman E.; Goodfellow, Dane G.;, Assignee: Hercules Incorporated (Wilmington, DE) |
DNA encoding polypeptide having nitrile hydratase activity and method for producing amides from nitriles with transformant containing the same
In the hydration of nitriles with a nitrile hydratase gene prepared by the cloning according to genetic engineering, many copies of the nitrile hydratase gene can be made to exist in a microorganism. ... Read More
Inventors: Beppu, Teruhiko; Horinouchi, Sueharu; Ikehata, Osamu; Endo, Takakazu;, Assignee: Nitto Chemical Industry Co., Ltd. (Tokyo, JP) |
Nucleotide sequences encoding pesticidal proteins
OF THE INVENTION Compositions and methods for controlling plant pests are provided. In particular, novel pesticidal proteins are provided which are produced during vegetative growth of Bacillus strai... Read More
Inventors: Warren, Gregory W.; Koziel, Michael G.; Mullins, Martha A.; Nye, Gordon J.; Carr, Brian; Desai, Nalini M.; Kostichka, Kristy; Estruch, Juan J.;, Assignee: Novartis Finance Corporation (New York, NY) |
Salt composition usable as a fused electrolyte in accumulators
We claim: 1. An alkali salt composition free from hydroxide, usable in its molten state as an anode electrolyte for accumulators with an alkali metal negative electrode and with an alkali alumina sepa... Read More
Inventors: Breda, Frederic; Jonville, Pierre; Bonomi, Angelo; Ambert, Jack;, Assignee: Proge Groupement d'Interet Economique (Paris, FR) |
Wood derived, thermoplastic ester mixtures as a substitute for petroleum-derived components in compounded rubber stocks
OF THE INVENTION INCLUDING THE PRESENTLY KNOWN BEST MODE FOR CARRYING IT OUT In the manufacture of rubber articles such as tires, several structural components actually make up the tire. Thus, some o... Read More
Inventors: Davis, James A.; Koch, Robert C.;, Assignee: The Firestone Tire & Rubber Company (Akron, OH) |
Reaction product of a rosin acid and an antidegradant
What is claimed is: 1. A reaction product of: (a) a rosin acid and (b) a polyfunctional compound having at least one functional group capable of reacting with a carboxylic acid functionality and anoth... Read More
Inventors: Wideman, Lawson G.; Sandstrom, Paul H.;, Assignee: The Goodyear Tire & Rubber Company (Akron, OH) |
Cysteine proteinase inhibitor
We claim: 1. Compound of the formula X-Gly-CHN.sub.2 wherein X is selected from the group consisting of Pro-Arg-Leu-Val-, Arg-Leu-Val-, Leu-Val-, Val-, and protected derivatives thereof, wherein the N... Read More
Inventors: Grubb, Anders; Abrahamson, Magnus; Trojnar, Jerzy;, Assignee: |
Epitaxin, a cell motility factor
OF THE INVENTION The present invention provides a substantially purified fibroblast-derived motility factor, epitaxin, that stimulates the migration of tumor cells, including tumor cells of epithelia... Read More
Inventors: Yamaguchi, Yu; Shimonaka, Motoyuki;, Assignee: La Jolla Cancer Research Foundation (Ja Jolla, CA) |
Manufacture of electrodes with lead base
We claim: 1. A process for the manufacture of a catalytic, lead electrode having an inactive base of lead or lead alloy and an active catalyst thereon, comprising; (a) producing a preformed, flat, coh... Read More
Inventors: Beer, Henri B.; Hinden, Jean M.; Honard, Mark R.; Bishara, Jeries I.; Walker, Jr., Joseph K.;, Assignee: ELTECH Systems Corporation (Boca Raton, FL) |
Substituted deoxyadenosine derivatives
OF THE INVENTION In the above general Formula I, the abbreviation Ado represents 5'-deoxyadenosine-5'-yl which is the univalent radical obtained by removal of the hydroxy group from the 5'-position o... Read More
Inventors: Bey, Philippe; Jung, Michel; Kolb, Michael; Danzin, Charles;, Assignee: Merrell Toraude et Compagnie (Strasbourg, FR) |
Process for the production of L-tryptophan using sulfaguanidine-resistant microorganisms
OF THE PREFERRED EMBODIMENTS The microorganism used in the process for the production of tryptophan of the present invention is a mutant belonging to the genus Corynebacterium or the genus Brevibacte... Read More
Inventors: Shiio, Isamu; Sugimoto, Shinichi; Kawamura, Kazue;, Assignee: Ajinomoto Company, Incorporated (Tokyo, JP) |
Hand-held automatic wire binding tool
We claim: 1. A tool for binding a pair of juxtapose elongate structural members together by utilizing a supply of wire said tool comprising a main body member having upper and lower ends thereto, a pa... Read More
Inventors: Powell, Robert Y.; Fisher, Jeff A.;, Assignee: |
Drugs 
