Novel saframycin A derivatives and process for producing the same
What is claimed is: 1. A process for the preparation of a compound of the formula ##STR4## wherein R represents hydrogen or C.sub.1 -C.sub.4 -alkyl comprising (a) suspending a biomass of a strain of s... Read More
Inventors: Arai, Tadashi; Mikami, Yuzuru;, Assignee: Arai; Tadashi (Tokyo, JP) |
Process for the preparation of a new-type active substance selectively inhibiting food intake
What we claim is: 1. A process for isolating a food intake suppressant from human or animal blood serum which comprises subjecting the human and/or animal blood serum to ultrafiltration on a membrane ... Read More
Inventors: Knoll, Jozsef; Nagy, Janos; Kalasz, Huba; Knoll, Berta;, Assignee: Richter Gedeon Vegyeszeti Gyar Rt. (Budapest, HU) |
Terminal methionyl bovine growth hormone and its use
According to the present invention, synthetic DNA is provided for a substantial portion of the initial coding sequence of a heterologous gene insert, and optionally, upstream therefrom through the ATG... Read More
Inventors: de Boer, Herman A.; Heynerer, Herbert L.; Seeburg, Peter H.;, Assignee: Genentech, Inc. (South San Francisco, CA) |
Human immune interferon
The present invention is based upon the discovery that recombinant DNA technology can be used to successfully produce human immune interferon, preferably in direct form, and in amounts sufficient to i... Read More
Inventors: Goeddel, David V.; Gray, Patrick W.;, Assignee: |
Method for production of an enzyme granulate
I claim: 1. In a process for production of an enzyme granulate which comprises granulating an enzyme composition comprising enzyme, filler, binder, and from 1.5-40% by weight thereof of cellulose or a... Read More
Inventors: Markussen, Erik K.;, Assignee: Novo Industri A/S (Bagsvaerd, DK) |
Process for preparing narasin
The new microorganism of this invention is a biologically pure culture derived from a soil sample collected near the Surinam River, Surinam, South America. The culture was given the number A-39912 fo... Read More
Inventors: Kastner, Ralph E.; Hamil, Robert L.;, Assignee: Eli Lilly and Company (Indianapolis, IN) |
Reversible optical waveguide vapor sensor
Accordingly, it is an object of the invention to detect small amounts of a chemical in air and in other gases. Another object is to provide a device for such purpose which can be used repeatedly witho... Read More
Inventors: Giuliani, John F.; Wohltjen, Henry;, Assignee: The United States of America as represented by the Secretary of the Navy (Washington, DC) |
Biotinidase-resistant biotinylated compound and methods of use thereof
This invention relates to biotinidase-resistant biotinylated compounds containing a chemical fragment having the structure: ##STR2## wherein R.sub.1 and R.sub.3 are independently hydrogen, carboxyl or... Read More
Inventors: Rosebrough, Scott F.;, Assignee: University of Rochester (Rochester, NY) |
Method of recovering shiga-like toxins and vaccines comprising inactivated shiga-like toxin
This invention provides a facile, efficient and reproducible method for recovering biologically active Shiga-like toxins from a sample using an affinity ligand covalently attached to an affinity suppo... Read More
Inventors: Vanmaele, Rosa; Armstrong, Glen D.;, Assignee: Synsorb Biotech, Inc. (Calgary, CA) |
Assays for shiga toxin and shiga-like toxins
OF THE INVENTION The present invention relates to a substantially pure antigenic or peptide protein related to Shiga toxin (ST) or Shiga-like toxins I or II (SLT-II, SLT-II) or SLT-II variants. The t... Read More
Inventors: Keusch, Gerald T.; Donohue-Rolfe, Arthur; Acheson, David W. K.;, Assignee: New England Medical Center Hospitals, Inc. (Boston, MA) |
Control of enterohemorrhagic E. coli 0157:H7 in cattle by probiotic bacteria and specific strains of E. coli
OF THE INVENTION Histologic examination of colonic tissue has revealed no evidence of attachment of E. coli O157:H7 to bovine colonic tissue. The rumen appears to be the most important site for long-... Read More
Inventors: Doyle, Michael P.; Zhao, Tong; Harmon, Barry G.; Brown, Cathy Ann;, Assignee: University of Georgia Research Foundation Inc. (Athens, GA) |
Feline leukemia virus vaccines
OF THE INVENTION Any immunogenic FeLV protein may be expressed in baculovirus following the methods and techniques described here. For instance, the location and sequences of the genes encoding gag, ... Read More
Inventors: Wardley, Richard C.; Thomsen, Darrell R.;, Assignee: |
Resolution of D,L-dehydroproline
I claim: 1. A method for the preparation of L-3,4-dehydroproline comprising in combination the steps of: A. treating N-protected D,L-3,4-dehydroproline with R(+)-alpha-methyl-p-nitrobenzylamine so as ... Read More
Inventors: Felix, Arthur Martin;, Assignee: Hoffmann-La Roche Inc. (Nutley, NJ) |
Quaternary salts as hypoglycemic agents
OF THE INVENTION The hypoglycemic agents of the present invention are synthesized by the reaction of a suitable halide with the appropriate heterocyclic ring system, depicted as follows: ##STR6## whe... Read More
Inventors: Kuhla, Donald E.;, Assignee: Pfizer Inc. (New York, NY) |
7-[.alpha.-(2-Aminomethyl-1-cyclohexenyl)-acetamido]-3-heterocyclic thiomethyl-3-cephem-4-carboxylic acids
We claim: 1. An acid having the formula ##SPC42## wherein R is ##SPC43## ##SPC44## or ##EQU1## or a nontoxic, pharmaceutically acceptable salt thereof. 2. The acid of claim 1 having the formula ##SPC4... Read More
Inventors: Naito, Takayuki; Okumura, Jun; Kamachi, Hajime;, Assignee: Bristol-Myers Company (New York, NY) |
Pasteurized therapeutically active protein compositions
What is claimed is: 1. A method of pasteurizing a composition comprising a thermally sensitive, therapeutically active protein selected from the group consisiting of antihemophilic factor (Factor VIII... Read More
Inventors: Fernandes, Peter M.; Lundblad, John L.;, Assignee: Miles Laboratories, Inc. (Elkhart, IN) |
Method of preparing a high-purity, virus safe, biologically active transferrin preparation
We claim: 1. A method of preparing a high-purity, virus-safe biologically active, transferrin preparation from plasma fractions that contain transferrin, comprising a) removing the .gamma.-globulins f... Read More
Inventors: Bethke, Ulf; Kothe, Norbert; Rudnick, Dieter; Moller, Wolfgang; Kloft, Michael;, Assignee: Biotest Pharma GmbH (Dreieich, DE) |
Hydrolyzable resin composition and an antifouling coating composition containing the same
What is claimed is: 1. A method of preventing marine fouling which comprises applying to a surface to be protected from fouling, an anti-fouling hydrolyzable resin composition consisting essentially o... Read More
Inventors: Yamamori, Naoki; Ohsugi, Hiroharu; Eguchi, Yoshio; Yokoi, Junji;, Assignee: Nippon Paint Co., Ltd. (Osaka, JP) |
Treatment for herpes virus
OF THE INVENTION According to the invention, I provide a composition for and method of use of such composition, for the topic treatment of herpes virus lesions, which comprises about 2-12% wt tannic ... Read More
Inventors: Tinnell, James E.;, Assignee: |
Microbicidal meta oxy- and thio-substituted phenylanilines
What is claimed is: 1. A compound of the formula I, including salts and metal complexes thereof ##STR52## wherein R.sub.1 and R.sub.2 independently of one another are each C.sub.1 -C.sub.4 -alkyl, C.s... Read More
Inventors: Eckhardt, Wolfgang; Kunz, Walter; Hubele, Adolf;, Assignee: Ciba-Geigy Corporation (Ardsley, NY) |
Synergistic microbiocidal composition containing a mixture of a bicyclic polyoxymethyleneoxazolidine and an acroloin/formaldehyde polycondensation product
We claim: 1. A microbiocidal composition comprising a synergistic mixture the first component of which is an acrolein/formaldehyde polycondensation product having a molar ratio of 1:2-1:4 and the seco... Read More
Inventors: Mahn, Frederick R.; Bogdany, Lora J.; Baron, Joseph J.; Knapick, Edward G.; Antonucci, Edward M.;, Assignee: Drew Chemical Corporation (Boonton, NJ) |
Substituted acyl derivatives of amino acids
OF THE INVENTION The invention in its broad aspects includes substituted acyl derivatives of amino acids having formula I above. The substituted acyl groups refer to the side chains on the carbon bet... Read More
Inventors: Ondetti, Miguel A.; Weisenborn, Frank L.;, Assignee: E. R. Squibb & Sons, Inc. (Princeton, NJ) |
Escherichia coliO-polysaccharide-protein conjugate vaccine
OF THE INVENTION The present invention relates to E. coli-protein conjugates for use in vaccines against E. coli. The present invention further relates to a method of producing such vaccines. The nov... Read More
Inventors: Cryz, Stanley J.; Furer, Emil P.;, Assignee: Swiss Serum and Vaccine Institute Berne (Berne, CH) |
Milk production
What is claimed is: 1. The method of improving rumen acetate/propionate ratios and milk production which is well known to be closely related to a high acetate/propionate ratio, and rises and falls in ... Read More
Inventors: Hahn, Peter A.; Abdo, Kamal M.;, Assignee: W. R. Grace & Co. (New York, NY) |
Heterocyclic compounds, processes for their preparation and their use
We claim: 1. A compound of general formula (I): ##STR14## in which the amide function is in the 2 or 3 position on the thiophene ring, and wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5, which... Read More
Inventors: Oxford, Alexander W.; Bradshaw, John; Coates, Ian H.;, Assignee: Glaxo Group Limited (London, GB2) |
Virus insecticide compositions
What is claimed is: 1. A particulate insecticidal composition comprising a free-flowing particle mass containing 0.1 to 35 percent by weight of a finely divided virus insecticide in which virions are ... Read More
Inventors: Rogoff, Martin H.; Shieh, Tsuong R.;, Assignee: Sandoz Pharm. Corp. (E. Hanover, NJ) |
Stable prostaglandin E group-containing formulation
OF THE INVENTION Now, as described above, thiol compounds, water-soluble high molecular weight compounds and/or water-soluble salts of deoxycholic acid are used as additives in this invention and exa... Read More
Inventors: Murakami, Masuo; Kawahara, Shigemi; Kawata, Hiroitsu; Okazaki, Kiyoshi; Sekino, Jun; Shimizu, Hidemi;, Assignee: Yamanouchi Pharmaceutical Co., Ltd. (Tokyo, JA) |
Medicinal facial mask
OF THE INVENTION The compositions of the present invention comprise a pharmaceutically and cosmetically acceptable formulations in which up to 20% by volume of an acid material selected from the grou... Read More
Inventors: Klein, Marvin E.;, Assignee: |
p75 TNF receptor promoters
OF THE INVENTION A human genomic library containing the human p75 TNF-R was obtained from Stratagene. This library was a phage library, from which 8 phages were positively identified as carrying the ... Read More
Inventors: Wallach, David; Kuhnert, Peter; Ehrhardt, Gotz; Kemper, Oliver;, Assignee: Yeda Research and Development Co. Ltd. (Rehovot, IL) |
Method of immunizing cats against shedding of Toxoplasma oocysts
I claim: 1. A method of immunizing a cat against shedding of Toxoplasma oocysts which comprises the steps of: initially infecting said cat by administering to the cat Toxoplasma microorganisms such th... Read More
Inventors: Frenkel, Jacob K.; Smith, Donald D.;, Assignee: The Kansas University Endowment Association (Lawrence, KS) |
Drugs 
