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 Pharmaceutical compositions for intranasal administration of calcitonin

Details
Inventors: Aliverti, Valerio; Dorigotti, Luciano; Fonio, Teodoro; Pinza, Mario;
Assignee: ISF Societa per Azioni (IT)
Primary Examiner: Robinson; Douglas W.
Assistant Examiner: Witz; Jean C.
Attorney, Agent or Firm: Dinner; Dara L., Venetianer; Stephen, Lentz; Edward T.

Compositions for the treatment of osteoporosis and related diseases comprise calcitonin and, as an absorption enhancer, a glycyrrhizinate.

DETAILED DESCRIPTION We claim: 1.
A pharmaceutical composition comprising a non-toxic, therapeutically effective amount of a calcitonin, a non-toxic effective amount of an absorption enhancer which is a glycyrrhizinate, and a pharmaceutically acceptable carrier.
2.
The composition according to claim 1 wherein the glycyrrhizinate is ammonium glycyrrhizinate.
3.
The composition according to claim 1 wherein the glycyrrhizinate is present in a concentration corresponding to at least 0.
1% (w/w) of the total weight of the composition.
4.
The composition according to claim 3 wherein the concentration of glycyrrhizinate is 0.
5 to 5% (w/w).
5.
The composition according to claim 1 wherein the calcitonin is elcatonin.
6.
The composition according to claim 1 wherein the calcitonin is eel calcitonin.
7.
The composition according to claim 1 in the form of a liquid or gel suitable for application to the nasal mucosa.
8.
The composition according to claim 7 wherein the glycyrrhizinate is present in an amount corresponding to approximately 2 g per 100 ml of composition.
9.
The composition according to claim 1 which is packaged for administration as a spray.
10.
The composition according to claim 8 which is packaged for administration as a spray.
11.
The composition according to claim 1 which has a pH in the range from approximately 4.
5 to approximately 6.
12.
The composition according to claim 1 wherein the calcitonin is elcatonin and the glycyrrhizinate is ammonium glycyrrhizinate.
13.
The composition according to claim 12 in the form of a liquid suitable for application to the nasal mucosa.
14.
The composition according to claim 13 which has a pH in the range from approximately 4.
5 to approximately 6 and is packaged for administration as a spray.
15.
The composition according to claim 14 wherein the glycyrrhizinate is present in an amount corresponding to approximately 2 g per 100ml of composition.
16.
The composition according to claim 1 wherein the calcitonin is eel calcitonin and the glycyrrhizinate is ammonium glycyrrhizinate



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