 Nucleic acid-containing polymerizable complex |
| OF THE INVENTION The present invention is based on the development of a polymerizable complex ... |
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| Chiral peptide nucleic acids and methods for preparing same |
| OF THE INVENTION Specific sequence recognition of DNA or RNA is of increasing importance for the ... |
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| Capillary electrophoretic detection of nucleic acids |
| OF THE PREFERRED EMBODIMENTS This invention provides novel methods for the detection and isolation ... |
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| PNA diagnostic methods |
| The present invention provides methods for detecting nucleic acid sequences and/or determining ... |
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| Histidine-containing peptide nucleic acids |
| OF THE INVENTION Specific sequence recognition of DNA or RNA is of increasing importance for the ... |
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| Two-step hybridization and capture of a polynucleotide |
| According to one aspect of the invention, there is disclosed a method of capturing a target ... |
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| Peptide nucleic acid conjugates |
| OF THE INVENTION According to the present invention a PNA oligomer is conjugated to a ligand ... |
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| High throughput assay system |
| This invention provides compositions, apparatus and methods for concurrently performing multiple ... |
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| Synthetic polymers and methods, kits or compositions for modulating the solubility of same |
| As previously discussed, the limited solubility of PNA oligomers, and particularly purine-rich ... |
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| Neurologically-active compounds |
| The inventors have found a class of compounds which are surprisingly selective GABAC receptor ... |
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Adipocyte-specific protein homologs
| Details |
Inventors: Sheppard, Paul O.; Humes, Jacqueline M.;
Assignee: ZymoGenetics, Inc. (Seattle, WA)
Primary Examiner: Kemmerer; Elizabeth
Assistant Examiner: Brannock; Michael
Attorney, Agent or Firm: Lingenfelter; Susan E.
The present invention relates to polynucleotide and polypeptide molecules for zsig39, a novel member of the family of proteins bearing a collagen-like domain and a globular domain. The polypeptides, and polynucleotides encoding them, are involved in dimerization or oligomerization and may be used in the study thereof. The present invention also includes antibodies to the zsig39 polypeptides. |
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DETAILED DESCRIPTION Within one aspect of the invention is provided an isolated polypeptide comprising a sequence of amino acid residues that is at least 80% identical to SEQ ID NO:2, wherein the sequence comprises: beta strands corresponding to amino acid residues 105-109, 128-130, 136-139, 143-146, 164-171, 176-182, 187-200, 204-210 and 226-231 of SEQ ID NO:2, wherein the beta strands are separated by at least two amino acid residues; and a receptor binding domain comprising amino acid residues 111-135 and 170-174 of SEQ ID NO:2.
Within one embodiment the polypeptide is at least 90% identical to SEQ ID NO:2.
Within another embodiment the polypeptide comprises a collagen-like domain having at least 22 collagen repeats.
Within another embodiment the polypeptide comprises residues 19-243 of SEQ ID NO:2.
Within yet another embodiment the polypeptide is covalently linked amino terminally or carboxy terminally to a moiety selected from the group consisting of affinity tags, toxins, radionucleotides, enzymes and fluorophores.
Within another aspect is provided.
an isolated polypeptide selected from the group consisting of: a) a polypeptide having a sequence of amino acid residues from amino acid residue 30 to amino acid residue 95 of SEQ ID NO:2; b) a polypeptide having a sequence of amino acid residues from amino acid residue 30 to aminc acid residue 96 of SEQ ID NO:2; and c) a polypeptide having a sequence of amino acid residues from amino acid residue 30 to 97 of SEQ ID NO:2; d) a polypeptide having a sequence of amino acid residues from amino acid residue 30 to amino acid residue 98 of SEQ ID NO:2; e) a polypept.
ide having a sequence of amino acid residues from amino acid residue 98 to amino acid residue 243 of SEQ ID NO:2; f) a polypeptide having a sequence of amino acid residues from amino acid residue 99 to amino acid residue 243 of SEQ ID NO:2; g) a polypeptide having a sequence of amino acid residues from amino acid residue 30 to amino acid residue 243 of SEQ ID NO:2; and h) a polypeptide having a sequence of amino acid residues that is 90% identical in amino acid sequence to a), b), c), d), e), f), g) or h)
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